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Voltage-gated Ca2+ (CaV) channels trigger glucose-induced insulin secretion in pancreatic beta-cell and their dysfunction increases diabetes risk. These heteromeric complexes include the main subunit alpha1, and the accessory ones, including subunit gamma that remains unexplored. Here, we demonstrate that CaV gamma subunit 4 (CaVγ4) is downregulated in islets from human donors with diabetes, diabe

Metal contamination of water bodies has attracted global attention owing to its environmental toxicity, abundance and persistence. Metals such as arsenic, cadmium and mercury are of greater concern since they are toxic even at low concentrations. Mercury is present at 1000 times lower concentrations than the other two metals, but still has a negative impact on the environment due to its high trans

In this study, we developed a nanoparticle-based mesoporous composite that consisted of silicate-titanate nanotubes (STNTs) supported in hydrogel chitosan beads (STNTs-Ch beads) and was studied for Cd2+ adsorption. By using Fourier-transform infrared spectroscopy, transmission and scanning electron microscopy coupled to an energy-dispersive X-ray spectrometer, we coulddetermine that the hollow STN

Objectives: Depressive symptoms in the elderly have been shown to be associated with increased mortality. The purpose of this study was to examine symptoms of depression in octogenarian men and their association with all-cause mortality, and whether physical, cognitive and social factors influence this association. Methods: Out of the 703 initially included 55-years-old men, from the prospective c

The time domain version of the optical theorem is discussed. The theorem is derived from the optical theorem in the frequency domain by the Parseval’s relation. It expresses the sum of the scattered and absorbed energies in terms of the scattered farfield in the forward direction. From the theorem, causality, and reciprocity a number of results concerning the scattered and absorbed energies from a

The survival and growth of intrahippocampal septal suspension grafts were investigated by acetylcholine esterase (AChE) histochemistry in animals with lesions of the intrinsic septohippocampal cholinergic pathways. AChE was demonstrable in the grafts after the first postoperative week, and AChE-positive fibres were seen to extend into the host hippocampus by 3 weeks. Rapid fibre outgrowth occurred

Religious argumentation is sometimes supposed to be different from other kinds of argumentation. George Kennedy for example mentions a radical Christian rhetoric in which the message is proclaimed rather than argued, but in my study of Paul’s first letter to the Corinthians I have found deliberate argumentation. This argumentation can be analyzed with Toulmin’s model of argumentation. The warrants

This conference paper discusses trouser roles and gender trouble connected with them on stage.

For as long as there have been supply chains, there have been disruptions, and no supply chain, logistics system, or infrastructure network is immune to them. Nevertheless, supply-chain disruptions have only recently begun to receive significant attention from practitioners and researchers. Hence, different mitigation and contingency strategies have been addressed. But there is still an almost unt