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β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan (GAG) chains. Natural and synthetic xylosides can be used to both inhibit and prime GAG synthesis by acting as inhibitors or substrates for β4GalT7. In this report, we exploit hydroxylated oxanes as deoxygenated xyloside analogs to clarify the minimum protein-ligand interactions required for galactosyl

Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circad

The third sector of national innovation systems comprises non-academic, publicly owned R&D organizations that complement universities and private-sector firms and are normally called ‘research institutes’. Scholarly attention to these organizations has been scarce, partly a consequence of the theoretical imbalance in favor of conceptualizations of innovation processes as requiring mainly unive

Pottiaceae subfam. Trichostomoideae in Scania, S Sweden – The members of Pottiaceae subfam. Trichostomoideae excluding Weissia spp. in the province of Skåne (Scania), southern-most Sweden, has been revised based on vouchers collected during the ongoing inventory of the bryophyte flora of the province. In addition, all available earlier records have been compiled and are presented for comparison (b

Key functions of civil society organizations (CSOs) are to criticize governments and to hold them to account. Recent trends of privatization and contracting out challenge CSOs’ opportunities to voice such criticism. The purpose of this article is to analyse whether and why CSOs ‘hold back their criticism’ of public authorities, and how a compromised advocacy can be linked to financial, organizatio

It is a well-institutionalised notion that information subjected to assurance (audit) by third parties contributes to better quality information for decision making. In the field of sustainability reporting, who are providing assurance and how is quality regulated? What are the challenges of regulating sustainability assurance through standards? What role can hard law play to strengthen reporting

Little is presently known about the unique nanostructure of deep eutectic solvents (DES). The order of the liquid-solid phase transition is contended and whether DES-water mixtures are merely aqueous solutions, or have properties dominated by the eutectic pair, is unclear. Here, we unambiguously show the structure of choline chloride-malic acid (malicine) as a liquid, and also in solid and hydrate

We surveyed 110 country churches in south-western Sweden for presence of brown long-eared bats Plecotus auritus in summer 2016 by visual inspection and/or evening emergence counts. Each church was also classified according to the presence and amount of aesthetic directional lights (flood-lights) aimed on its walls and tower from the outside. Sixty-one of the churches had previously been surveyed b

Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue samples to serve as a transcriptional reference. In this study, we performed in-depth analyses of normal kidney tissue transcriptomes from the TCGA and demonstrate that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between sam

Enhanced heat transfer tubes (EHTT) with segmented mesh-conical frustums are considered. Tube diameter and frustum apex angle are fixed as 20 mm and 60o, respectively. The height ratio of frustum and sliced part are set as a golden ratio (1.618). Laminar thermal-hydraulic performance and effects of some parameters, e.g., bottom frustum diameter and pitch, are numerically simulated. The equal equiv

Introduction Pregnancy rates after frozen embryo transfer (FET) have improved in recent years and are now approaching or even exceeding those obtained after fresh embryo transfer. This is partly due to improved laboratory techniques, but may also be caused by a more physiological hormonal and endometrial environment in FET cycles. Furthermore, the risk of ovarian hyperstimulation syndrome is pract

Complexation between multiple weak polyacid chains and a positively charged spherical nanoparticle has been studied by means of Monte Carlo simulations. By considering titration curves, it is found that variations in the polyacid chain length and concentration and the polyacid-to-nanoparticle mixing ratio influence the ionization of the system. For larger mixing ratios and longer chain lengths, th

Background: Switch from first line antiretroviral therapy (ART) to second-line ART is common in clinical practice. However, there is limited knowledge of to which extent different reason for therapy switch are associated with differences in long-term consequences and sustainability of the second line ART. Material and methods: Data from 869 patients with 14601 clinical visits between 1999–2014 wer

Discrimination has long been tied to health inequality. Rejected by families and communities because of their gender identity and gender-role behavior, transgender individuals are often socially marginalized. This study aimed to assess discrimination in health-care settings among persons self-identifying as transgender in the U.S. in relation to their recognizability as transgender, operationalize

The incidence of children born with congenital heart disease is 1%. Congenital heart disease is among the birth defects that lead to the longest hospital stays, and children with congenital heart disease often require frequent hospitalization and several heart operations, along with lifelong follow-up visits. This study aims to describe parents’ experiences when their child has a heart defect and

The adsorption and charge transfer dynamics of the organic molecule bi-isonicotinic acid (4,4-dicarboxy-2,2-bipyridine) on single crystal Ag(111) has been studied using synchrotron radiation-based photoemission, x-ray absorption, and resonant core spectroscopies. Measurements for multilayer and monolayer coverage are used to determine the nature of the molecule-surface interactions and the molecul

Due to the fragmented organizational landscape characterizing public transport, it is important to study and explore how regional governance of public transport adapts to national institutional reforms. By employing the term ‘governance cultures’ to a comparative case study of regional public transport planning in Sweden, we contribute to theories of governance by cultural sensitization. Combining