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BCL11A is a major regulator of fetal hemoglobin production. Reduced levels of BCL11A have been shown to delay switching from fetal to adult hemoglobin, suggesting that it acts as a stage-specific repressor of gamma globin expression. We have carried out a survey of BCL11A binding in the globin, BCL11A and GATA1 loci by ChIP-on-chip analysis in primary human erythroid cells. We found strong occupan

Individual variation in fetal hemoglobin (HbF, alpha(2)gamma(2)) response underlies the remarkable diversity in phenotypic severity of sickle cell disease and beta thalassemia. HbF levels and HbF-associated quantitative traits (e.g., F cell levels) are highly heritable. We have previously mapped a major quantitative trait locus (QTL) controlling F cell levels in an extended Asian-Indian kindred wi

HBS1L-MYB intergenic polymorphism (HMIP) on chromosome 6q23 is associated with elevated fetal hemoglobin levels and has pleiotropic effects on several hematologic parameters. To investigate potential regulatory activity in the region, we have measured sensitivity of the sequences to DNase I cleavage that identified 3 tissue-specific DNase I hypersensitive sites in the core intergenic interval. Chr

Recension av "Dröm och verklighet: Stellan Arvidson - kärleken, dikten och politiken", av Birgitta Almgren

Recension av "Efter revolutionen - Vänstern i svensk kulturdebatt sedan 1968", av Lennart Berntson & Svante Nordin)

Living labs as a research approach have been said to hold many promises regarding the evaluation of state-of-the art technologies in real-world contexts, for instance by allowing close cooperation with various stakeholders. At the same time, a living lab approach is connected with substantial complexity and increased risk. This paper elaborates on a conducted living lab with the objective to explo

Many natural and industrial proteins are known to have properties that can result in type I hypersensitivity, however, to date, no validated test system exists that can predict the sensitizing potential of these allergens. Thus, the objective of this study was to develop a protocol based on the myeloid cell-based Genomic Allergen Rapid Detection (GARD) assay that can be used to assess and predict

Effects of oxygenated fuels on soot reduction strongly depend on the base fuel. Interesting candidates from oxygenated fuels in this respect include both n-butanol and 2,5-dimethylfuran (DMF), because they have already been used in diesel engines recently. However, information is rather limited on n-butanol and DMF added into a diesel fuel surrogate in fundamental flames to investigate the mechani

Security in organizations is no longer just a matter of having locks and alarms; it is more like a question of different dimensions of rules, perceptions and actions. The focus must return to more interpersonal relationships in security issues instead of technically advanced equipment. In facing today’s challenges, the focus must be on more interpersonal relationships in security issues than on te

Declining trust in representative institutions is considered one of the most significant political problems of our time. It is often suggested that democratic innovations—or mechanisms which aim to increase and deepen citizen participation in the political decision-making process—can help reverse this trend. However, empirical research about actual effects of participation on trust is scarce, and

Here, it is shown that when two optical frequency combs with identical mode spacing but different offset frequencies copropagate through a nonlinear optical fiber, four-wave mixing between them generates new modes. Although the spacings between the new modes depend on the difference of the offset frequencies, they appear irregular because of the large number of possible four-wave-mixing processes.

We investigate the local changes in photophysics at different microregions of a methylammonium lead bromide (MAPbBr3) perovskite crystal under illumination. Our results show that the emission from the structurally homogeneous region is blue-shifted compared to the emission from the inhomogeneous regions. The yield and spectrum of the emission from the structurally homogeneous region do not vary wi

Astaxanthin (AXT) is a reference model of xanthophyll carotenoids, which is used in medicine and food industry, and has potential applications in nanotechnology. Because of its importance, there is a great interest in understanding its molecular properties and aggregation mechanism in water and mixed solvents. In this paper, we report a novel model of AXT for molecular dynamics simulation. The mod

Normal incidence x-ray standing wave experiments and density functional theory reveal that 3,4,9,10-perylene-tetracarboxylic-dianhydride chemisorbs on Ag(111) in a nonplanar but vertically distorted configuration. The carboxylic O atoms are 0.18±0.03   Å closer to the surface than the perylene core. The distortion is related to weak, local bonds between carboxylic O atoms and the Ag surface which

Boron is an attractive high-energy fuel additive. But it could not burn efficiently in practical systems due to its high ignition temperature and slow burning velocity. Finding methods to enhance the combustion of boron is desired. This work focused on the combustion characteristics of boron submicroparticles with and without plasma discharges in a hot environment supported by CH4/N2/O2 flat flame