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Knowledge of which genes and pathways are affected by inbreeding may help understanding the genetic basis of inbreeding depression, the potential for purging (selection against deleterious recessive alleles) and the transition from outcrossing to selfing. Arabidopsis lyrata is a predominantly self-incompatible perennial plant, closely related to the selfing model species A. thaliana. To examine ho
European CH4 and N2O emissions are estimated for 2006 and 2007 using four independent inverse modelling systems, based on different global and regional Eulerian and Lagrangian transport models. This ensemble approach is designed to provide more realistic estimates of the overall uncertainties in the derived emissions, which is particularly important for verifying bottom-up emission inventories. We
To date, there are no known methods for preventing acute kidney injury after cardiac surgery. Increasing evidence suggests that erythropoietin has renal antiapoptotic and tissue protective effects. However, recent human studies have shown conflicting results. The authors aimed to study the effect of a single high-dose erythropoietin preoperatively on renal function after coronary artery bypass gra
Aim: The aim of this study is to explore how women from part of the world where female genital mutilation (FGM) is normative perceive and experience FGM after immigrating to Sweden. Method: Interviews were conducted with eight women from Djibouti, Eritrea, Ethiopia and Somalia. The data were analyzed using qualitative content analysis. Results: The women's feelings were ambivalent: though they opp
We have performed a large-scale test of alchemical perturbation calculations with the Bennett acceptance-ratio (BAR) approach to estimate relative affinities for the binding of 107 ligands to 10 different proteins. Employing 20-Å truncated spherical systems and only one intermediate state in the perturbations, we obtain an error of less than 4 kJ/mol for 54% of the studied relative affinities and
Frequency-modulated light scattering interferometry, which employs a frequency-modulated coherent light source and examines the intensity fluctuation of the resulting scattered light using a heterodyne detection scheme, was utilized to evaluate the optical properties of liquid phantoms made of Intralipid(R) and Indian ink. Based on the diffusion theory, nonlinear fits to the power spectrum of the
In this work, we focus on the computational bridging between the meso- and macro-scale in the context of the hybrid modelling of Internal Traverse Grinding with electro-plated cBN wheels. This grinding process satisfies the manufacturing industry demands for a high rate of material removal along with a high surface quality while minimising the number of manufacturing processes invoked. To overcome
Platelets are rapidly responsive sentinel cells that patrol the bloodstream and contribute to the host response to infection. Platelets have been reported to form heterotypic aggregates with leukocytes and may modulate their function. Herein we have investigated platelet-neutrophil complex formation and neutrophil function in response to distinct agonists. The endogenous platelet activator thrombi
Heat stress at the workplace is an occupational health hazard that reduces labour productivity(1). Assessment of productivity loss resulting from climate change has so far been based on physiological models of heat exposure(1). These models suggest productivity may decrease by 11-27% by 2080 in hot regions such as Asia and the Caribbean(2), and globally by up to 20% in hot months by 2050(3). Using
Human fibrocytes are bone marrow-derived mesenchymal progenitor cells that express a variety of markers related to leukocytes, hematopoietic stem cells and a diverse set of fibroblast phenotypes. Fibrocytes can be recruited from the circulation to the tissue where they further can differentiate and proliferate into various mesenchymal cell types depending on the tissue niche. This local tissue nic
Introduction: A significant proportion of high-risk breast cancer families are not explained by mutations in known genes. Recent genome-wide searches (GWS) have not revealed any single major locus reminiscent of BRCA1 and BRCA2, indicating that still unidentified genes may explain relatively few families each or interact in a way obscure to linkage analyses. This has drawn attention to possible be
Let P be a set of n points in the Euclidean plane and let O be the origin point in the plane. In the k-tour cover problem (called frequently the capacitated vehicle routing problem), the goal is to minimize the total length of tours that cover all points in P, such that each tour starts and ends in O and covers at most k points from P. The k-tour cover problem is known to be NP-hard. It is also kn
In this study, we examine individual patent holders and the fate of their inventions. A unique database consisting of over 800 private individuals who have obtained decision rights over a new technology in Sweden is used to analyse how opportunity and individual level characteristics are related to the likelihood that patented inventions are commercialised in a new or existing small firm. Our find
To determine benefits and harms of arthroscopic knee surgery involving partial meniscectomy, debridement, or both for middle aged or older patients with knee pain and degenerative knee disease.
Recent developments in the application of x-ray micro-tomography in laboratory geomechanics have allowed all the individual grains of sand in a test sample to be seen and identified uniquely in 3D. Combining such imaging capabilities with experiments carried out ‘‘in situ’’ within an imaging set-up has led to the possibility of directly observing the mechanisms of deformation as they happen. The c
The transverse momentum (p(T)) dependence of the nuclear modification factor R-AA and the centrality dependence of the average transverse momentum
To investigate whether apoM is excreted in urine of children undergoing heart surgery and the potential of apoM as early biomarker of acute kidney injury (AKI).
