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The Wilms' tumor gene 1 (WT1) protein is a transcriptional regulator that is highly expressed in immature hematopoietic progenitor cells and in the majority of patients with acute and chronic myeloid leukemia. However, it is still unclear how WT1 exerts its function(s) in hematopoietic cells. The aim of this work was to investigate the function of WT1 as a transcription factor in human hematopoiet
Popular Abstract in Swedish Faderskap är en familjepolitisk angelägenhet där staten går in och intervenerar och på så sätt fostrar fäder. Tyngdpunkten ligger på att uppmuntra fadersnärvaro och att förmå frånvarande fäder att ta ansvar för sina barn. Detta ger oss en bild av vad som uppfattas som bra fäder och vad som avviker från normen. Den sociala barnavården är en kontext som verkar inom den soThis dissertation deals with fathers of children subjected to child welfare investigations. They are "fathers called into question" and their fatherhood is not very much investigated so far. The dominating picture is that the fathers are absent, to their children as well as in research and social work literature. Two Swedish contexts are presented. These represent different interpretations of "the
Adolescence is a period when teens normally revolt against being dependent. For teens with asthma this period may be even more difficult to deal with, as they also have to deal with their illness. Since few studies describe this phenomenon, the aim of this study was to provide a theoretical understanding of how teens with asthma manage their everyday life in relation to their disease. A grounded t
Three new species, i.e. Hieracium evae I Tyler, Hieracium jonsbergense T. Tyler, Hieracium subnitidum Dahlst. ex T. Tyler, and one variety, i.e. H. ravidum Brenn. var. exaltifrons T. Tyler var. nov. are described. Hieracium myrtillinum (Johanss. ex Dahlst.) T. Tyler comb. nova is proposed. All are based on material collected in the SE Swedish provinces Gotland and Ostergotland.
The capacity of downlink cellular multiple-input multiple-output (MIMO) systems, where co-channel interference is the dominant. channel impairment, is investigated in this paper, mainly from a signal-processing perspective. Turbo space-time multiuser detection (ST MUD) is employed for intracell communications and is shown to closely approach the ultimate capacity limits in Gaussian ambient noise f
We found that engagement of beta (2) integrins on human neutrophils induced activation of RhoA, as indicated by the increased ratio of GTP:GTP + GDP recovered on RhoA and translocation of RhoA to a membrane fraction. The clustering of beta (2) integrins also induced a time-dependent increase in GDP bound to RhoA, which correlated with beta (2) integrin-induced activation of p190RhoGAP. The activat
Polymer-droplet interactions have been Studied in AOT/water/isooctane oil-continuous microemulsions mixed with an amphiphilic graft copolymer. or with the parent homopolymer (AOT = sodium bis(2-ethylhexyl) sulfosuccinate). The graft copolymer has an oil-soluble poly(dodecyl methacrylate) backbone and water-soluble poly(ethylene glycol) side chains. Pseudo-ternary polymer/droplet/isooctane phase di
The recipients of blood components, from the first 12 anti-hepatitis C virus (HCV) positive donors identified by blood donor screening, 1985-1991, were traced retrospectively and tested to assess the HCV transmission rate, HCV genotypes and disease severity. Three enzyme-linked immunosorbent assay (ELISA) positive but RIBA-indeterminate and HCV RNA-negative donors did not transmit HCV to their 9 t
In a prospective study of a consecutive breast cancer series accumulated in the period 1978-82, the S-phase fraction (SPF) and ploidy status were determined by flow cytometry performed on cell nuclei derived from samples of 580 primary tumors. Sixty percent of the tumors were non-diploid. After correction for debris the median SPF values were 7.3% overall, 12% for non-diploid tumors, and 2.9% for
In this paper we present a precise and reliable measurement of the 1s(2)2p P-2(3/2) lifetime for Li-like Ni. The measurement was done using the technique of beam-foil spectroscopy employing a beam of 5.9 MeV/u Ni from the UNILAC accelerator at GSI. Special attention was taken concerning satellite blending and foil-ageing problems to justify the reliability of the lifetime value extracted from the
This review summarizes and discusses the use of central health registers in studies of causes of congenital malformations. The review is illustrated using data from the Swedish Medical Birth Register with adjacent registers and gives examples of different methods to identify environmental exposures. The review stresses the usefulness of this approach but also the inherent problems of which the res
