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Popular Abstract in Swedish Alzheimers sjukdom är den vanligaste orsaken till uppkomsten av demens. Detta tillstånd innebär att delar av hjärnan skrumpnar på ett karakteristiskt vis, när nervceller går under. Den drabbade brukar först märka svårigheter med korttidsminnet, för att senare drabbas av språksvårigheter, räknesvårigheter, svårigheter med rumslig uppfattning och svårigheter att veta hur Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. Efforts to develop effective treatments for humans have mostly been based on the assumption that a faulty homeostasis of beta amyloid (Aβ) is the triggering or the driving factor behind this co

The properties of two-component fermionic quantum systems in two dimensions, such as they nowadays may be realized with cold atoms in traps, are studied within the pairing model adapted from nuclear physics. We compare the results with those of a full numerical diagonalization of the many-body Hamiltonian. The chemical potential differences, excitation energies and angular momentum spectra show th

The elliptic, v(2), triangular, v(3), and quadrangular, v(4), azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions, and (anti-)protons in Pb-Pb collisions at root S-NN = 2.76 TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range vertical

The average charge states of Pb-188 and No-252,No-254 ions in dilute helium gas were measured at the gas-filled recoil separator TASCA. Hydrogen gas was also used as a filling gas for measurements of the average charge state of No-254. Helium and hydrogen gases at pressures from 0.2 mbar to 2.0 mbar were used. A strong dependence of the average charge state on the pressure of the filling gases was

Difference between sexes in parasitism is a common phenomenon among birds, which may be related to differences between males and females in their investment into immune functions or as a consequence of differential exposure to parasites. Because life-history strategies change sex specifically during the annual cycle, immunological responses of the host aiming to reduce the impact of parasites may

The behaviour of building occupants before the purposive movement towards an exit, known as the pre-evacuation behaviour, can have a strong impact on the total time required to leave a building in case of fire emergency as well as on the number of casualties and deaths. The pre-evacuation time can be simulated within computational models using different approaches. This work introduces a new model

Modelers seeking to help inform decisions about insurance (public or private) coverage of the cost of pharmaceuticals or other health care interventions face various methodological challenges. In this review, which is not meant to be comprehensive, we cover those that in our experience are most vexing. The biggest challenge is getting decision makers to trust the model. This is a major problem bec

The superfamily of cyclic nucleotide phosphodiesterases is comprised of 11 gene families. By hydrolyzing cAMP and cGMP, PDEs are major determinants in the regulation of intracellular concentrations of cyclic nucleotides and cyclic nucleotide-dependent signaling pathways. Two PDE3 subfamilies, PDE3A and PDE3B, have been described. PDE3A and PDE3B hydrolyze cAMP and cGMP with high affinity in a mutu

Haemophilus influenzae serotype f (Hif) is an etiologic agent of bacterial invasive disease. Here, we report the first annotated genome sequence of the Hif strain KR494, which was isolated from a patient suffering from sepsis and necrotizing myositis. The genome sequence will increase the understanding of Hif pathogenesis.

En normativ analys av argument för ett land att "gå före" i klimatarbetet.

Abstract in Undetermined There has been an increasing interest in applying GIS into health and healthcare research in recent years.4,5 However, this increasing interest has not yet been gauged. In order to address this, the current study was performed to examine the crude number and the annual rate of papers with ‘Geographic Information Systems’ among their MeSH Terms in PubMed (a free database wh

We present azimuthal anisotropy measurements in Au+Au and Cu+Cu collisions at and 200 GeV. Comparison between reaction plane and cumulant v2 measurements in Au+Au collisions at GeV shows that non-flow contributions, originating mainly from jets, influence the extracted v2 for pT 3.5 GeV/c. Number of constituent quark (NCQ) scaling of v2, when studied as a function of transverse kinetic energy KET,