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Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults

Background: Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described. Methods: Sixty healthy subjects 25 males, 35 females, age 55 to 83 years, body mass index > 25 kg/m(2)) were included in a cross-over study with 5 hours of

HAMLET interacts with lipid membranes and perturbs their structure and integrity.

BACKGROUND: Cell membrane interactions rely on lipid bilayer constituents and molecules inserted within the membrane, including specific receptors. HAMLET (human alpha-lactalbumin made lethal to tumor cells) is a tumoricidal complex of partially unfolded alpha-lactalbumin (HLA) and oleic acid that is internalized by tumor cells, suggesting that interactions with the phospholipid bilayer and/or spe

Identification of the sex pheromone of the spruce seed moth, Cydia strobilella L.

The spruce seed moth, Cydia strobilella L., is a serious pest on cones of spruce (Picea spp.) in the Holarctic region. Previous studies from different parts of its area of distribution have reported conflicting results on the composition of its sex pheromone. By gas chromatography with electroantennographic detection, coupled gas chromatography-mass spectrometry, a Y-tube olfactometer bioassay, an

The influence of microstructure and mechanical properties on the machinability of martensitic and bainitic prehardened mould steels

The machinability of two prehardened mould steels, one continuously-cooled and one quenched and tempered, is compared in terms of cutting temperature, cutting force and tool life. Both materials have a hardness of similar to 40 HRC which is a typical hardness for prehardened mould steels. The results of machinability tests are related to mechanical properties and microstructural features, and the

Downregulation of the cancer susceptibility protein WRAP53β in epithelial ovarian cancer leads to defective DNA repair and poor clinical outcome.

Alterations in the scaffold protein WRAP53β have previously been linked to carcinogenesis and, in particular, associated with an increased risk for epithelial ovarian cancer. Here, we investigated the pathogenic impact and prognostic significance of WRAP53β in connection with epithelial ovarian cancer and examined the underlying mechanisms. We find that reduced expression of WRAP53β in ovarian tum

Search for second generation scalar leptoquarks in pp collisions at root s=7 TeV with the ATLAS detector

The results of a search for the production of second generation scalar leptoquarks are presented for final states consisting of either two muons and at least two jets or a muon plus missing transverse momentum and at least two jets. A total of 1.03 fb(-1) integrated luminosity of proton-proton collision data produced by the Large Hadron Collider at root s = 7 TeV and recorded by the ATLAS detector

Reflection and transmission properties of a wall-floor building element: comparison between finite element model and experimental data.

Changes in the Swedish construction code introduced in 1994 enabled the construction of wooden multi-storey buildings. The main issue in those is disturbing vibrations and noise propagating throughout the construction. Therefore, gaining knowledge about their behavior is of crucial importance for the industry. In this study, a mockup of a wall/floor junction was investigated by comparing both expe

An implementation guide for the use and development of the EEB_Sweden Model v1.0

The objective of this report is to provide an implementation guide to understanding the Energy Efficiency in Buildings (EEB) model as applied to the Swedish Residential sector. The report depicts the work that prepares the ground to use and test the model to evaluate energy efficiency policy instruments targeting the Swedish residential sector during the next phase of the project. It is argued wil

Measurements of Large-Scale Parameters of a Distributed MIMO Antenna System in a Microcell Environment at 2.6 GHz

Multi-site multi-antenna measurements for semiurban microcell environment at 2.6 GHz are performed with four base stations (BSs) and one mobile station (MS). Three BSs are provided with four antenna elements in closely spaced copolarized configuration, and one BS is provided with a single antenna element. The MS is equipped with a cylindrical uniform array consisting of 64 dual-polarized antenna e

Developmental regulation of smooth muscle contraction in the urinary bladder

Smooth muscle cells in the urinary bladder are involved in the control of urine filling and emptying. We have used mice to study the contractile regulation of urinary bladder smooth muscle during the fetal period. We found that nerve-induced contractions are mainly dependent on muscarinic receptor activation in the newborn whereas adult bladders are equally dependent on muscarinic and purinergic r

Growth Mechanism of Self-Catalyzed Group III-V Nanowires.

Group III-V nanowires offer the exciting possibility of epitaxial growth on a wide variety of substrates, most importantly silicon. To ensure compatibility with Si technology, catalyst-free growth schemes are of particular relevance, to avoid impurities from the catalysts. While this type of growth is well-documented and some aspects are described, no detailed understanding of the nucleation and t

Data Adaptive Estimation of Transversal Blood Flow Velocities

The examination of blood flow inside the body may yield important information about vascular anomalies, such as possible indications of, for example, stenosis. Current medical ultrasound systems suffer from only allowing for measuring the blood flow velocity along the direction of irradiation, posing natural difficulties due to the complex behaviour of blood flow, and due to the natural orientatio