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The natural unsaturated 1,4-dialdehydes warburganal (6), polygodial (14), isovelleral (55) and merulidial (56a) and their corresponding unconjugated aldehyde isomers (121), (15), (108) and (109a) were prepared, and their bioactivity and reactivity towards various nucleophiles were investigated. New synthetic routes to prepare (-)-6 and its isomer (+)-121 from (-)-14, and (+)-109a from (-)-56a, ha

Popular Abstract in Swedish Vår kropp består till stor del av proteiner. De bygger upp vår kropp, låter oss röra på armar och ben, se, höra, tänka och känna. Proteiner byggs av cellerna utifrån den individuella ritning - DNA - som vi alla bär med oss i cellernas innersta kärnor. Lika livsviktigt som det är att kunna tillverka alla tusentals olika proteiner är det att kunna bryta ned dem i lagom tIt is a necessity of life to make proteins, and it is an equal necessity to degrade those proteins, to eliminate dysfunctional proteins, and leave room for new ones. The processes of protein synthesis and degradation into peptides - proteolysis - have attracted a great interest during the last decades. The eye contains several highly specialized tissues, in which the protein turnover is of vital

Random-walk and diffusion models for two-choice comparison of paired successive or simultaneous stimuli focus on response time (RT), modeled as the time needed to reach one or the other barrier, and its relation to the response probabilities. Logit P1 = ln[P1/(1-P1)], where P1 is the probability of responding ”first greater,” can be seen as a measure of subjective stimulus difference, d. Signed re

Popular Abstract in Swedish De senaste årens framsteg inom bioteknologin har medfört att det utvecklas allt fler proteinbaserade läkemedel. Detta innebär att vi har fått bättre mediciner mot allvarliga sjukdomar, men tyvärr måste proteiner nästan alltid tas med spruta, och ofta krävs långa behandlingar med dagliga injektioner. Det finns även andra grupper av läkemedelssubstanser som ökar i omfattnControlled-release formulations reduce the frequency of injections and better maintain plasma concentrations within the therapeutic window. Poly(D,L-lactide-co-glycolide) (PLG) is currently the most frequently used biodegradable polymer for this application. In order to be able to control the release rate, it is vital to know the underlying release mechanisms. A novel method for measuring the diff

1998 lanserade regeringen ett nytt initiativ inom regional näringspolitik. Genom regionala tillväxtavtal (RTA) skulle större hänsyn tas till länens olika förutsättningar, vilket förväntades främja sysselsättning och tillväxt. De regionala tillväxtavtalen skulle tas fram genom två förhandlings-rundor: en inomregional samt en mellan respektive län och den centrala, statliga nivån. Utformningen av R

An alternative to the standard endurance/perdurance accounts of persistence has recently been developed: the stage theory (Sider, T. Four-Dimensionalism: an Ontology of Persistence and Time. Oxford: Oxford University Press, 2001; Hawley, K. How Things Persist. Oxford: Oxford University Press, 2001). According to this theory, a persisting object is identical with an instantaneous stage (temporal pa

JastAddJ is an extensible Java compiler, implemented using reference attribute grammars. It has been shown previously how the language constructs of Java 5, like generics, could be modularly added to the original JastAddJ compiler that supported Java 1.4. In this paper we discuss our experiences from extending Jast- AddJ to support Java 7. In particular, we discuss how the Try-With-Resources state