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BACKGROUND: Amplification of the oncogene MYCN in double minutes (DMs) is a common finding in neuroblastoma (NB). Because DMs lack centromeric sequences it has been unclear how NB cells retain and amplify extrachromosomal MYCN copies during tumour development. PRINCIPAL FINDINGS: We show that MYCN-carrying DMs in NB cells translocate from the nuclear interior to the periphery of the condensing chr

Wnt signaling is important in development and can also contribute to the initiation and progression of cancer. The Secreted Frizzled Related Proteins (SFRPs) constitute a family of Wnt modulators, crucial for controlling Wnt signaling. Here we investigate the expression and role of SFRP3 in melanoma.

Prevention strategies are critical to reduce infection rates in total joint arthroplasty (TJA), but evidence-based consensus guidelines on prevention of surgical site infection (SSI) remain heterogeneous and do not necessarily represent this particular patient population.

The escape from the Middle Ages: An escape from the Middle Ages is observed among Medieval archaeologists. The author argues that the etsablishment of Medieval archaeology as a discipline was closely connected to the rise of an urban archaeology. Consequently, the main background to the escape from the Middle Ages is the decline of urban archaeology. In correlation, it might even be seen as an esc

The traditional view of asthma has changed considerably during the last decades. A paradigm shift in our understanding of asthma has turned our focus from the importance of muscle spasm to inflammation. Today asthma is believed to be a central airway inflammatory disorder, and the importance of activated eosinophils found in central airway biopsies and in induced sputum is believed to be a hallmar

Artikeln är en essäliknande diskussion om orgelns identitet och plats i västerländsk kulturhistoria utifrån David Yearsleys bok "Bach's Feet: The Organ Pedals in European Culture" (Cambridge UP, 2012). Fokus ligger på J.S. Bach, tysk kulturhistoria och historieskrivandets avgörande roll för att förstå nutida debatter om orgelinstrumentet.

Both road traffic noise and air pollution have been linked to cardiovascular disease. However, there are few prospective epidemiological studies available where both road traffic noise and air pollution have been analyzed simultaneously. The aim of this study was to investigate the relation between road traffic noise, air pollution and incident myocardial infarction in both current (1-year average

The fourth International Society of Blood Transfusion (ISBT) workshop on molecular blood group genotyping was held in 2010, with a feedback meeting at the ISBT Congress in Berlin, Germany. Fifty laboratories participated, 17 more than in 2008. Six samples were distributed. Samples 1-3 were DNA samples for all red cell blood group tests available to the participants. Of the 46 laboratories that tes

Kulturartikel (uppföljare till "Terrorattacken svepte bort tvillingtornen ur filmens värld) om amerikansk film efter attacken mot World Trade Center den 11 september 2001. Nu handlar det om förändringar av actionfilmens skräckscenarior och skurkstereotyper, framgången för samhällskritiker som Noam Chomsky och väntade filmer om 9-11.

The mechanisms by which mycobacteria subvert the inflammatory defence to establish chronic infection remain an unresolved question in the pathogenesis of tuberculosis. Using primary epithelial cells, we have analysed mycobacteria induced epithelial signalling pathways from activation of TLRs to cytokine secretion. Mycobacterium bovis bacilli Calmette-Guerin induced phosphorylation of glycogen synt

Prey organisms often use multiple sensory cues to gain reliable information about imminent predation threat. In this study we test if a freshwater fish increases the reliance on supplementary cues when the reliability of the primary cue is reduced. Fish commonly use vision to evaluate predation threat, but may also use chemical cues from predators or injured conspecifics. Environmental changes, su

PURPOSE: To explore areas in which the education at the Pakistan Institute of Prosthetic & Orthotic Science (PIPOS) could be improved or supplemented to facilitate clinical practice of graduates. To describe educational opportunities PIPOS graduates have had since their graduation and explore their further educational needs. METHOD: 15 graduates from PIPOS participated in semi-structured inte

Abstract is not available