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Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most contemporary childhood ALL treatment protocols. The main objectives of this thesis were to investigat

The isotopes (122),(124),Cd-126 were studied in a "safe" Coulomb-excitation experiment at the radioactive ion-beam facility REX-ISOLDE at CERN. The reduced transition probabilities B(E2; 0(g. s)(vertical bar) -> 2(1)(+)) and limits for the quadrupole moments of the first 2(+) excited states in the three isotopes were determined. The onset of collectivity in the vicinity of the Z = 50 and N = 82 sh

A search is performed for collimated muon pairs displaced from the primary vertex produced in the decay of long-lived neutral particles in proton-proton collisions at root s = 7 TeV centre-of-mass energy, with the ATLAS detector at the LHC. In a 1.9 fb(-1) event sample collected during 2011, the observed data are consistent with the Standard Model background expectations. Limits on the product of

Classical conditioning of a motor response such as eyeblink is associated with the development of a pause in cerebellar Purkinje cell firing that is probably an important driver of the overt response. This conditioned Purkinje cell response is adaptively timed and has a specific temporal profile that probably explains the time course of the overt behavior. It is generally assumed that the temporal

The growing need for valid assessment procedures of the outdoor thermal environment in the fields of public weather services, public health systems, urban planning, tourism & recreation and climate impact research raised the idea to develop the Universal Thermal Climate Index UTCI based on the most recent scientific progress both in thermo-physiology and in heat exchange theory. Following exte

A patient with an initial diagnosis of TIA presented with a deceptive course of events and unfavorable outcome. Only a non-enhanced brain CT was performed initially. Hemodynamic studies were clone later on and revealed internal carotid artery (ICA) dissection on CT-angiography and evidence of irreversible ischemic changes on perfusion studies indicating that the ischemic process presumably was ong

In this article we review aspects of charge and heat transport in interacting quantum dots and molecular junctions under stationary and time-dependent non-equilibrium conditions due to finite electrical and thermal bias. In particular, we discuss how a discrete level spectrum can be beneficial for thermoelectric applications, and investigate the detrimental effects of molecular vibrations on the e

The rational for studying health consequences of social determinants is to enable understanding of factors that affect population patterns of health, disease and well-being in order to produce knowledge useful for guiding policies and actions to reduce social inequalities in health and promote social well-being. The aims of this study have been to investigate the association between aspects of soc

The “iron triangle” phenomenon, or nexus between politicians, bureaucrats and business, is an important element of the Japanese postwar political economy system, known as the “1955 system” or “Japan Inc.” Although, originally created to facilitate high-speed economic growth by ensuring efficient cooperation between the government and business, over time it became associated with high-profile corru

Objectives To describe the clinical and ultrasound characteristics of granulosa cell tumors (GCTs) of the ovary, and to define the ultrasound appearance of GCTs based on pattern recognition. Methods Databases of four gynecological ultrasound centers were searched to identify patients with histologically proven GCTs who had undergone a standard preoperative ultrasound examination. Results A total o

Popular Abstract in Swedish Hårdare krav på lägre energianvändning i byggnader samt ökade energipriser har gjort att välisolerade hus har blivit vanligare. Ökad medvetenhet om koldioxidens påverkan på klimat-förändringarna har också ökat intresset för trähus. Tjockare isolering ökar dock risken för höga fukttillstånd och med detta också risken för fuktskador. För att förutse och undvika fuktskadorDue to increased awareness of climate change and higher energy costs, well-insulated buildings have become more common. Furthermore, interest in the use of wood in building to produce more carbon dioxide-efficient buildings has increased. However, thicker thermal insulation in building envelopes increases the risk of high relative humidity levels and the risk of mold-related damage in wood frame b

Bombus terrestris is one of the most commonly used insect models to investigate visually guided behavior and spatial vision in particular. Two fundamental measures of spatial vision are spatial resolution and contrast sensitivity. In this study, we report the threshold of spatial resolution in B. terrestris and characterize the contrast sensitivity function of the bumblebee visual system for a dua

Two preferential attachment-type graph models which allow for dynamic addition/deletion of edges/vertices are considered. The focus of this paper is on the limiting expected degree of a fixed vertex. For both models a phase transition is seen to occur, i.e. if the probability with which edges are deleted is below a model-specific threshold value, the limiting expected degree is infinite, but if th

The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or "Purkinje cell CRs" to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the infe

In the presence of excess hydrogen peroxide (H2O2), ferrous (Fe(+2)) human hemoglobin (Hb) (α2β2) undergoes a rapid conversion to a higher oxidation ferryl state (Fe(+4)) which rapidly autoreduces back to the ferric form (Fe(+3)) as H2O2 is consumed in the reaction. In the presence of additional H2O2 the ferric state can form both ferryl Hb and an associated protein radical in a pseudoperoxidative

Endovascular aneurysm repair (EVAR) is a valid treatment option for abdominal aortic aneurysm (AAA). The outcome of infrarenal EVAR is dependent on choosing patients with appropriate anatomy to allow for good proximal and distal seal. In the absence of an infrarenal neck of adequate length and quality, fenestrated stent-graft repair has emerged as an alternative treatment option. For the past deca

Ideologisk analys av Anders Behring Breiviks föreställningsvärld i ljuset av en populärkulturell tradition av manliga actionhjältar, främst i relation till filmatiseringarna av Jan Guillous Hamiltonromaner.