Closed-loop controlled drug dosing has the potential of revolutionizing clinical anesthesia. However, interpatient variability in drug sensitivity poses a central challenge to the synthesis of safe controllers. Identifying a full individual pharmacokinetic–pharmacodynamic (PKPD) model for this synthesis is clinically infeasible due to limited excitation of PKPD dynamics and presence of unmodeled d

Today, semi-conductor nanowires can be grown with very high precision, using epitaxy. This allows for studies of new nanowire-based quantum devices, likely to be part of novel quantum technologies in the future. This thesis concerns nanostructures based on InAs nanowires. More specifically, it concerns the theoretical treatment of two types of nanowire-based structures: InAs/GaSb core-shell (and c

Sociologisk Forskning bad fyra sociologer i Sverige att svara på några korta frågor om coronapandemin och vårt samhälles hantering av den.Deras tidigare forskning har på olika sätt berört olika frågor såsom socialmedicin och medicinsk kunskapsproduktion, sociala nätverks betydelse för smittspridning, samhällets hantering av kriser och risker, genusaspekter av samhällskriser samt dynamiken mellan e

Background: It is known that patients who acquired methicillin-resistant Staphylococcus aureus (MRSA) in hospitals suffer and feel as plague. Moreover, the patient interaction with nurses and physicians is described as frightening. Little is known about patient experiences after having acquired CA-MRSA concerning care and everyday life. Aim: To reveal and interpret otherwise healthy patients’ live

Introduction: The acoustic environment in the intensive care unit patient room, with high sound levels and unpredictable sounds, is known to be poor and stressful. Therefore, the present study had two aims: to investigate staff knowledge concerning noise in the intensive care unit and: to identify staff suggestions for improving the sound environment in the intensive care unit patient room. Method

There is a need for patient-reported experience measures (PREMs) in high-tech hospital environments based on the philosophy of person-centeredness. The aim of this study was to describe the development and initial psychometric evaluation of a measure of person-centeredness by means of being taking seriously. In this cross-sectional survey, the study sample (n = 79) completed two measures, the Bein

Background: Sedation practices in the intensive care unit have evolved from deep sedation and paralysis toward lighter sedation and better pain management. The new paradigm of sedation has enabled early mobilization and optimized mechanical ventilator weaning. Intensive care units in the Nordic countries have been particularly close to goals of lighter or no sedation and a more humane approach to

Patients in an intensive care unit (ICU) may risk disruption of their circadian rhythm. In an intervention research project a cycled lighting system was set up in an ICU room to support patients' circadian rhythm. Part I aimed to compare experiences of the lighting environment in two rooms with different lighting environments by lighting experiences questionnaire. The results indicated differences

An extraordinarily diverse and well-preserved material, including the remains of 47 insect taxa and 12 taxa of other invertebrates, extracted from the 17th century burial of Bishop Peder Winstrup in Lund Minster, is presented and discussed in terms of the treatment of the body, activities connected with the burial and faunal significance. The invertebrate assemblages include species from gardens,

Abstract: Volatile emissions of vehicle brakes relate to the high temperature of the brake friction pair. However, as a passive parameter of braking applications, temperature is usually studied together with other parameters such as sliding speed and load. Heating tests that increase the friction pair temperature with an induction heater instead of friction are proposed in this study to imitate th

Cu is required to be abated in brake pads due to its toxicity. There are on the market several Cu-free brake pads. These Cu-free brake pads are only evaluated regarding their friction and wear performance, whereas, their airborne particle emissions are not considered. A pin-on-disc tribometer is used to evaluate the friction, wear and airborne particle emission from two Cu-free commercial brake pa

Particulate matter emission factors from vehicle brakes are difficult to assess directly from the field. Moreover, there is a lack of a standardized cycle and test stand for evaluating brake emissions. For these reasons, a test cycle was developed from real driving data collected from a car. This new test cycle was implemented on an inertia disc brake dynamometer appositely designed for brake part

Disc brake creep groan is a stick-slip phenomenon which results in a low frequency noise in road vehicles that could occur at low vehicle speeds and brake torques. Simulation approaches are used predict the stick-slip phenomena for disc brakes. These approaches depend on the friction model used. Tribometers can be used to map how the local coefficient of friction (CoF) depends on the contact press

Copper from vehicles disc brakes is one main contributor of the total copper found in the environment. Therefore, the U.S. Environmental Protection Agency (EPA) and the automotive industries started the Copper-Free Brake Initiative. The pad friction material is essentially composed of a binder, fillers, reinforcing fibres and frictional additives. Copper and brass fibres are the most commonly used

Brake-related airborne particulate matter contributes to urban emissions in the transport sector. Recent research demonstrated a clear dependence of the number of ultra-fine particles on the disc brake temperature. Above the so-called transition temperature, the number of ultra-fine particles increases dramatically (several magnitudes). As for exhaust emissions, part of the emissions released duri

Emissions from disc brake wear adversely affect the air quality in cities. Finite Element Analysis (FEA)approaches focussing on the macroscopic wear of pads and rotors can be found in the literature, but none of these take the wear and emission dependence of the local contact pressure and sliding speed into account. The aim of the present study is to further develop an FEA approach for simulation

Friction, wear, and emission performance strongly depend on the contact pressure and area at the interface of the pad and disc. The contact situation at the pad-to-disc interface can be explained by the formation and destruction of mesoscopic sized contact plateaus on the pad surface. Experimental studies report that the initial surface roughness of cermet-coated discs strongly affects friction, w

Most freight wagons in the EU use cast iron brake blocks. Cast iron brake blocks have a stable braking capability in different environmental conditions, but wear down the wheel tread quickly. Therefore, there is a need to understand the tribology of other brake block materials. A pin-on-disc tribometer placed in a temperature-controlled chamber is used to investigate the tribology of cast iron, si