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Interactions between the cell cycle machinery and transcription factors play a central role in coordinating terminal differentiation and proliferation arrest. We here show that cyclin-dependent kinase 6 (Cdk6) is specifically expressed in proliferating hematopoietic progenitor cells, and that Cdk6 inhibits transcriptional activation by Runx1, but not C/ EBP alpha or PU. 1. Cdk6 inhibits Runx1 acti

The finite impulse response (FIR) function of the proposed filter is realised by integrating weighted signal currents in a given time window on a capacitor. The resulting capacitor voltage becomes the filter output, periodically available between integration and reset. In such an FIR filter, the hardware cost is delinked to the number of taps,

The bioelectrocatalytical reduction of H2O2 based on direct electron transfer (ET) between polycrystalline silver and the heme containing active site of horseradish peroxidase (HRP) is studied and compared with that obtained at gold. Native HRP and recombinant wild type HRP, containing additionally a six-histidine tag at the N-terminus, NHisrHRP, have been used for adsorptive modification of the e

The remarkable variation in plumage and morphological characters in the redpoll complex Carduelis flammea-hornemanni has puzzled taxonomists for several decades. In contrast, molecular studies have not revealed any genetic differentiation among the phenotypic redpoll forms. This could either be a result of high present-day gene flow or morphological differentiation following a rapid and recent pop

The additional transplantation of ex vivo generated hematopoietic (post)-progenitor cells represents a possible approach to ameliorate high-dose chemotherapy induced cytopenia. We investigated the feasibility of the large-scale expansion and transplantation of autologous megakaryocytic cells in four patients with advanced solid tumors. Up to 1,460x10(6) ex vivo generated cells were administered wi

In winter, small birds should be fat to avoid starvation and lean and agile to escape predators. This means that they face a tradeoff between the costs and benefits of carrying fat reserves. Every day they must gain enough fat to survive the coming night. Food-hoarding species can afford to carry less fat than nonhoarders because they can store energy outside the body. Furthermore, hoarders should

Temperature is an important factor regulating microbial activity and shaping the soil microbial community. Little is known, however, on how temperature affects the most important groups of the soil microorganisms, the bacteria and the fungi, in situ. We have therefore measured the instantaneous total activity (respiration rate), bacterial activity (growth rate as thymidine incorporation rate) and

High-resolution records of plant macrofossils, magnetic susceptibility, and total carbon content, complemented by pollen data, were obtained from a postglacial lake sediment sequence at alpine Lake Stentjarn (987 m a.s.l.), in west-central Sweden. Holocene vegetational and environmental changes were reconstructed from the data, with particular emphasis on the deglacial establishment of terrestrial

Studiens syfte var att undersöka hur många föräldrar som efter förlossningen önskade kontinuitet mellan graviditet och nyföddhetsperiod genom ett hembesök av den barnmorska som man lärt känna under graviditeten, hur dessa kvinnor och män formulerade sina erfarenheter och behov, om de skilde sig från föräldrar som inte önskade hembesök och om resultatet kunde ge synpunkter på en individualiserad hä

This thesis focuses on the provision and management of water supply and sanitation in housing areas in the City of Dar es Salaam. The main objective of the study is to contribute to knowledge and understanding of provision and management of urban water supply and sanitation in Tanzania in the context of sustainable urbanisation. A sectoral and single problem issue study approach was avoided and in

This thesis asks how developments in The Swedish Social Democratic Party’s welfare ideology over the past 70 years can be understood, using the conceptual lenses of Keynesian, Neoliberal and Social Investment welfare ideals. To answer this question, the thesis models a tailor-made seminal analytical tool; a code scheme of numerous operational indicators for Keynesian, Neoliberal and Social Investm

Considering the depersonalization that the bureaucratic role entails, it is interesting to analyze the bureaucratic role-play that occurs between public and private sphere from a dramaturgical perspective. In order to investigate the personal shift of bureaucrats’ attitude, I conducted participant observations and interviews at an office of a Swedish Agency. Based on critical theory and feminist c

Ever since the principle of sovereignty was established in Europe after the peace of Westphalia in 1648, the importance of belonging to a state has increased. And in today's society, during a time filled with a lot of wars and a major refugee crisis, having a citizenship has never been more important. Having a citizenship means that you get certain rights, but also obligations towards the stat

The 12th of April 2016, the European Parliament held a debate concerning the migration on the Mediterranean Sea. The issue has turned into a political crisis that has divided the member states of the European Union. This study intends to examine whether geographical distance may condition solidarity. Through an argumentative analysis, arguments by Swedish, Finnish, Greek and Italian members of the

Den här uppsatsen ämnar att förstå Islamiska statens propaganda och kommer med deras egna tidskrift som heter Dabiq, utforska innehållen för att förstå syftet med Islamiska statens propaganda. Materialet består av 15 artiklar och kommer med en narrativ metod som består av tre strategiska narrativ, identifiera mönster inom Islamiska statens propaganda. Metoden kompletteras med teori om strategiska

The Sweden Democrats, an anti-immigration and populist political party, gained ground in the Swedish North in both the 2010 and 2014 national elections. The key purpose of this thesis is to investigate the reasons for the Sweden Democrats electoral success in the North of Sweden, a geographical region where electors historically have voted for left parties. In doing so the thesis offers an investi

In this paper two different concepts are analyzed: information disorder and cooperation. Psychological warfare has become an increasingly pressing problem during the past few years. Several different notions are being used within the concept, including disinformation, misleading information and information disorder. Problems occur when one has a concept, but no legal definition for it. Hence is th