The transcription factor Wilms tumor gene 1, WT1, is implicated both in normal developmental processes and in the generation of a variety of solid tumors and hematological malignancies. Physical interactions of other cellular proteins with WT1 are known to modulate its function. We previously identified the Krppel-like zinc-finger protein, ZNF224, as a novel human WT1-associating protein that enha

Current cardiovascular risk scores do not include obesity or fat distribution as independent factors, and may underestimate risk in obese individuals. Assessment of early vascular ageing (EVA) biomarkers including arterial stiffness, central blood pressure, carotid intima-media thickness and flow-mediated vasodilation may help to refine risk assessment in obese individuals in whom traditional card

-The atrial switch operation Mustard- or Senning operation for transposition of the great arteries (TGA) was introduced in the late 1950s and was the preferred surgery for TGA until the early 1990s. The Mustard- and Senning operation involves extensive surgery in the atria and leaves the right ventricle as the systemic ventricle. The Mustard and Senning cohort is now well into adulthood and we beg

Subcutaneous continuous infusion of apomorphine has been shown to effectively reduce off-time and dyskinesias in Parkinson's disease (PD). In this multicentre observational cohort study we investigated motor effectivity, tolerability and patient satisfaction with subcutaneous apomorphine infusion therapy over a follow-up period of 2 years. 62 PD patients were included (34 women, 28 men; median age

Machine strength grading of structural timber is based upon relationships between so called indicating properties (IPs) and bending strength. However, such relationships applied on the market today are rather poor. In this paper, new IPs and a new grading method resulting in more precise strength predictions are presented. The local fibre orientation on face and edge surfaces of wooden boards was

This article analyzes the migration experiences of thirteen separated minors who arrived in Sweden between 1943 and 2008. Using the framework of the “liberated self” this chapter shows that the experiences of separated minors are shaped in the intersection between contexts and conditions of transnational migration and the Swedish reception system. Their efforts to continue living based on the past

Benign fibrous histiocytomas (FH) can be subdivided into several morphological and clinical subgroups. Recently, gene fusions involving either one of two protein kinase C genes (PRKCB and PRKCD) or the ALK gene were described in FH. We here wanted to evaluate the frequency of PRKCB and PRKCD gene fusions in FH. Using interphase fluorescence in situ hybridization on sections from formalin-fixed par

Abstract in Undetermined general method for determining stress concentration factors for laminated glass balustrades with two plus two bolt fixings with variable positions is developed. It is demonstrated how the stress concentration factors can be presented graphically in design charts and representative charts are displayed for the case of a more specific bolt-fixed balustrade type. In general,

The formation of multilamellar vesicles (MLVs) from the lamellar phase of nonionic surfactant system C12E5/D2O under shear flow is studied by time-resolved small angle neutron and light scattering during shear flow. A novel small angle neutron scattering sample environment enables the tracking of the lamellae alignment in the velocity-velocity gradient (1-2) plane during MLV formation, which was t

Objective. Worldwide prevalence estimates of systemic lupus erythematosus (SLE) range from 3 to 207 per 100,000, depending on region and population, SLE definition, case sources, and other methodologic considerations. We aimed to determine the prevalence of SLE in Sweden on January 1, 2010, using population-based registers. Methods. Linking multiple national registers, we identified all possible i

The structure of quasi-2d solutions of dipolar superballs in the fluid state has been determined by Metropolis Monte Carlos simulations in the absence and the presence of an external field. Superballs are 3d objects characterized by a one shape parameter. Here, superballs resembling cubes, but possessing rounded edges, have been used. Examination has been made for several magnitudes of the dipole

Due to the present shortage of He-3 and the associated tremendous increase of its price, the supply of large neutron detection systems with He-3 becomes unaffordable. Alternative neutron detection concepts, therefore, have been invented based on solid B-10 converters. These concepts require development in thin film deposition technique regarding high adhesion, thickness uniformity and chemical pur

Cancer of unknown primary site (CUP) may be called an orphan disease, as it is diagnosed when metastases are detected while the primary tumor typically remains undetected, and because little research has been done on its primary causes. So far, few epidemiological studies, if any, have addressed possible risk factors for CUP. We analyzed data from the European Prospective Investigation into Cancer

We highlight some results from our detailed abundance analysis study of 703 kinematically selected F and G dwarf stars in the solar neighbourhood. The analysis is based on spectra of high-resolution (R = 45 000 to 110 000) and high signal-to-noise (S/N approximate to 150 to 300). The main findings include: (1) at a given metallicity, the thick disk abundance trends are more alpha-enhanced than tho

Background: Parkinson's disease (PD) is associated with progressive mobility and walking difficulties. Although these aspects have been found to be central from a patient perspective, the perceived significance of walking is less well understood. Objective: To explore the significance of walking as perceived and experienced by individuals with PD. Methods: Eleven persons with PD (seven men; median

Background Androgens acting via the androgen receptor (AR) stimulate production of prostate specific antigen (PSA), which is a clinical marker of prostate cancer (PCa). Since genetic variants in the AR may have a significant impact on the risk of being diagnosed with PCa, the aim was to investigate if AR-variants were associated with the risk of having PSA above clinically used cut-off thresholds

A search for strongly produced supersymmetric particles is conducted using signatures involving multiple energetic jets and either two isolated leptons (e or mu) with the same electric charge, or at least three isolated leptons. The search also utilises jets originating from b-quarks, missing transverse momentum and other observables to extend its sensitivity. The analysis uses a data sample corre

This paper uses data from an observational study, conducted at access points in straight sections of primary roads in Malaysia in 2012, to investigate the effects of motorcyclists' behavior and road environment attributes on the occurrence of serious traffic conflicts involving motorcyclists entering primary roads via access points. In order to handle the unobserved heterogeneity in the small samp