Filetype
Non-differentiating bacteria adapt to starvation induced growth arrest by a complex turn-on/turn-off pattern of protein synthesis. This response shows distinct similarities with those of spore formation in differentiating organisms. A substantial amount of information on the non-growth biology of non-differentiating bacteria can be derived from studies on Vibrio strains. One important result is th
Carbon starvation induces the development of a starvation- and stress- resistant cell state in marine Vibrio sp. strain S14 (CCUG 15956). The starved cells remain highly responsive to nutrients during prolonged starvation and exhibit instantaneous severalfold increases in the rates of protein synthesis and RNA synthesis when substrate is added. In order to elucidate the physiological basis for the
The response of marine Vibrio sp. strain S14 (CCUG 15956) to long-term (48-h) multiple-nutrient starvation (i.e., starvation for glucose, amino acids, ammonium, and phosphate simultaneously) can be described as a three-phase process. The first phase, defined as the stringent control phase, encompasses an accumulation of guanosine 5'-diphosphate 3'-diphosphate (ppGpp) and decreases in RNA and prote
A transcriptional reporter fusion has been introduced into the chromosomal ftsZ locus in such a way that all transcription that normally reaches ftsZ can be monitored. The new Φ(ftsZ-lacZ) fusion yields four times more β-galactosidase activity than a ddlB-ftsQAZ-lacZ fusion on a lambda prophage vector. A strongly polar ddlB::Ω insertion prevents contributions from signals upstream of the ftsQAZ pr
Underpinning the project of massification of higher education (HE) is the stated aim to make HE accessible and equitable to all those who could benefit from it. Nevertheless, key metrics of success–access and participation, retention, degree outcomes–reveal inequalities related to race, gender and social class. Policies at both institutional and national levels, across international settings, aim
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycans (GAG) that transfers the first galactose unit to xylose in the linker region. Searching for new inhibitors of the GAG biosynthesis, we used saturation transfer difference (STD) nuclear magnetic resonance (NMR) spectroscopy to evaluate the binding interactions between β4GalT7 and several pentosides in
While pregnancy clearly reduces the risk for Alcohol Use Disorder (AUD) onset, we know less about the impact on AUD risk of having young children and how these effects vary across maternal age and level of maternal AUD genetic risk. Therefore, in 1.2 million parous Swedish women born 1960-1995, we examined those with a first registration for AUD between ages 15-40 while first pregnant, or while ra
BACKGROUND: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease primarily affecting the axial skeleton causing pain, inflammation, and stiffness. Individuals with axSpA are at greater risk of developing cardiovascular disease, which can be counteracted by physical activity. High-intensity interval training (HIIT) has been shown to improve cardiovascular health, but the effect on dise
Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine-rich proteoglycans, has emerged as a versatile actor in various malignant diseases. The aim of this study was to further explore the potential clinical significance
BACKGROUND: This systematic review and meta-analysis aimed to assess the diagnostic test accuracy of blood-based biomarkers (BBMs) for detecting Alzheimer's disease (AD) pathology in cognitively impaired individuals in specialized care settings. The overarching goal is to inform the development of a clinical practice guideline, led by the Alzheimer's Association, for use in clinical practice. METH
Förlossningen är en omvälvande och minnesvärd livshändelse. Den nyblivna mammans fokus ligger på det nyfödda barnet, likaså vårdpersonalens. En förlossning kan leda till allvarliga skador på bäckenbotten (pelvic floor, PF), ibland med komplikationer som inkontinens. Tyvärr förbises eller tonas dessa skador ofta ned – både av nyblivna mödrar och vårdgivare. I Sverige drabbas ungefär 1–4% av kvinnorGiving birth is a profound life event. Most of the time, mothers move their attention to their newborn, as do healthcare providers. Childbirth can cause severe pelvic floor (PF) injuries, potentially leading to complications, such as incontinence. Despite their impact, these injuries are often deprioritised or normalised—both by postpartum women and healthcare providers. In Sweden, 1–4% of women w
We study the role of self-promotion and career advice in sustaining gender differences in labor market outcomes. We conduct an online experiment in which “advisers” advise “workers” to choose between a more ambitious and a less ambitious task based on the worker’s subjective self-assessment. We find that women have lower self-assessments and receive less ambitious career advice as a result. We als
To examine whether processing of negated meanings is facilitated in highly predictable contexts and proceeds incrementally rather than with a delay, we asked participants to read highly constraining sentences containing negated adjectives (e.g., awake/responding/commercial) that were either strongly expected in a high-cloze condition (awake), weakly expected in a low-cloze condition (responding),
Vi har sedan 2009 ordnat seminarier som ger klara och handfasta besked på centrala fastighetsrättsliga ämnen. Denna gång är ämnet Grannelagsrätt. Rättsförhållanden mellan grannar i 3 kap jordabalken utgör grunden för grannelagsrätten, men grannelagsrättsliga frågor regleras även i miljöbalken och plan- och bygglagen.
