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Background: The transcription factor signal transducer and activator of transcription 3 (STAT3) is implicated in cancer drug resistance, metastasis, and immunosuppression and has been identified as a promising therapeutic target for new anticancer drugs. Myeloid-derived suppressor cells (MDSCs) play a major role in the suppression of antitumor immunity and STAT3 is involved in the accumulation, ge

To investigate the relation between joint involvement in the upper extremities and grip force in patients with early rheumatoid arthritis (RA). An inception cohort of 225 patients with early RA was followed according to a structured protocol. The same rheumatologist assessed all patients for swollen joints and joint tenderness. Grip force was measured (Grippit; AB Detektor, Gothenburg, Sweden) at

The unknown role of the carrier protein transthyretin (TTR) in mechanisms of functional recovery in the postischemic brain prompted us to study its expression following experimental stroke. Male C57/B6 mice (age 9 to 10 weeks) were subjected to permanent focal ischemia induced by photothrombosis (PT) and brain tissues were analyzed for ttr expression and TTR levels at 24 hours, 48 hours, 7 days an

A new generation of N-heterocyclic carbene palladium(II) complexes containing vinyl groups in different positions in the backbone of the N-heterocycle have been developed. The fully characterised monomers were copolymerised with divinylbenzene to fabricate robust polymer supported NHC-PdII complexes and these polymers were applied as heterogeneous catalysts in directed C-H halogenation of arenes w

Epidemiological data indicate decreased risk for development and growth of abdominal aortic aneurysm (AAA) among patients with diabetes mellitus (DM). On the other hand, DM adds to increased cardiovascular (CV) morbidity and mortality. In a nationwide observational cohort study of patients registered in the Swedish Vascular Register and the Swedish National Diabetes Register, we evaluated potentia

Purpose: The purpose of this paper is to study the effects of dimple geometries and arrangements on the heat transfer enhancement in a dimple jacketed heat exchanger. Design/methodology/approach: For the purpose of this paper, with the experimental validated numerical model, this paper carries out numerical simulations of both single dimples with different geometries and the whole dimple jacketed

Vi tittar upp nattetid och ser att vår Jord har en måne kretsande runt sig. Denna kallar vi Månen, och den har vi utforskat med hjälp av rymdsonder, olika landare och med hjälp av Apollo-astronauterna. Andra planeter har också månar kretsande runtom sig. Månar som ser helt annorlunda ut än vad vår egen Måne, vissa är små och ser ut som asteroider medans andra är så isiga att de skulle kunna förvanAs we look up at night we see that our Earth has one moon orbiting it, the one we call the Moon. We have explored our moon with orbiters, rovers and astronauts, mapping it and studying its history.Other planets also have moons in orbit around them and these may look quite different from the Earth's moon. Some are small and look like asteroids, others are so icy they would become comets if they plu

As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. SMCs are highly specialized cells with the main fu

Objective: To investigate whether patients’ pre-consultation knowledge of the time frames for the consultation influences the actual consultation time and/or patient and physician related outcomes; satisfaction and enablement. Design: Randomised controlled blinded intervention study. Setting: Four strategically chosen Primary Health Care Centres (PHCC:s) in Kronoberg county in Sweden participated.

Aim: To test the feasibility of a fully automated artificial intelligence-based method providing PET measures of prostate cancer (PCa). Methods: A convolutional neural network (CNN) was trained for automated measurements in 18F-choline (FCH) PET/CT scans obtained prior to radical prostatectomy (RP) in 45 patients with newly diagnosed PCa. Automated values were obtained for prostate volume, maximal

Aims: Research on the effect of unmet health-care needs on mortality at follow-up is scarce. This study investigated whether unmet health-care needs in 2008 were associated with a higher risk of mortality during a five-year follow-up period in a population in southern Sweden, and whether the association was stronger for particular subgroups of cause of death. Methods: The 2008 public-health survey

The key issue in urban drainage (UD) systems, looking from a control engineering perspective, is operation. Measurements, feedback, control and automation are tools to address the challenges. Measurement technology combined with analysis and parameter estimation are used to obtain relevant information for decision and control. The UD control problem is truly multivariable with many sensors and act