Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV), including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), are autoimmune conditions associated with small vessel inflammation. Earlier studies indicate that complement activation via the alternative pathway plays a major role in the pathogenesis. In this study we have investigated if ANCA-activati

Background: Careful assessment of the reasons for discontinuation of active surveillance (AS) is required for men with prostate cancer (PCa). Objective: Using Movember's Global Action Plan Prostate Cancer Active Surveillance initiative (GAP3) database, we report on reasons for AS discontinuation. Design, setting, and participants: We compared data from 10 296 men on AS from 21 centres across 12 co

There is an increasing research interest in the recovery of cooling capacity stored in cryogenic liquids (CLs) for industrial applications, especially for LNG regasification systems. In this study, a novel heat exchanger network (HEN) has been designed for cryogenic liquid regasification process to recover the released cooling capacity and develop a frozen-free heat transfer system with compact st

In this work, an automated downstream process for the purification and formulation of a recombinant protein was integrated at lab scale in a single chromatography unit. The purification chain consists of three bind-and-elute chromatography columns, a flow-through membrane chromatography step, and a final ultrafiltration-diafiltration (UFDF) step to concentrate and formulate the sample. An integrat

Importance: Drug company payments to health care organizations can create conflicts of interest. However, little is known about such financial relationships, especially outside the United States.Objective: To examine the concentration and patterns of drug company payments to health care organizations in the United Kingdom.Design, Setting, and Participants: This cross-sectional study examined nonre

In this study, a high-speed, fast responsive, non-intrusive ultrasonic thermometry system was proposed as a potential candidate for overcoming the disadvantages of thermocouples. The principle of this system is based on the thermal dependence of the speed of sound, and the temperature is measured by detecting the flight time of ultrasonic wave (USW) between the transmitter and the receiver. For a

Background: Can we validate a contagion model for drug abuse (DA) in Propinquity-of-Rearing Defined Acquaintances (PRDAs)? Methods: PRDAs were defined as pairs of same-age males born 1975–1990 who grew up within 2 km of each other, one of whom (PRDA1) being first registered for DA in national registries. Using adult residential location, we predicted, using regression splines, proximity-dependent

In this communication, we reconcile the kinematic method illustrated by some authors (Yang et al. in Microfluid Nanofluid 22:44–56, 2018; Vitali et al. in RSC Adv 8:38955, 2018) in studying the impact of system and suspension parameters on acoustophoretic separations with the statistical method formerly proposed by Garofalo (Microfluid Nanofluid 18(3):367–382, 2014a; ASME 2014 3rd global congress

Purpose: The aim of the study was to compare overall survival (OS) and disease-free survival (DFS) after open and robotic radical hysterectomy for early-stage cervical cancer. Patients and methods: This was a nationwide population-based cohort study on all women with cervical cancer stage IA1-IB of squamous, adenocarcinoma or adenosquamous histological subtypes, from January 2011 to December 2017,

Purpose: The purpose of this paper is to investigate the profitability of urban chicken production in the medium-sized cities of Kisumu and Thika, Kenya. Design/methodology/approach: Data were collected in 2016 from a sample of 157 indigenous chicken producers in the two cities. Descriptive analyses were used to characterize indigenous chicken production, marketing and profitability. In addition,

Emotional vocabulary and symbols on social media abound, not only in private communication, but also in organizations and workplace organizing. In this paper, we argue that emotional labor driven by technical developments is an important but hitherto rather overlooked dark side of digitalization. We thereby take a critical perspective on the techno-utopian literature of social media organizing, by