Little information exists on the possible teratogenic effect of modern antiobesity drugs. The present study refers to orlistat, sibutramine, and rimonabant. Data in the Swedish Medical Birth Register were utilised. During the years 1998-2011, among 392,126 infants born, 509 had been exposed to antiobesity drugs in early pregnancy: 248 to orlistat, 242 to sibutramine, 12 to rimonabant, 13 to unspec

Mate preferences are abundant throughout the animal kingdom with female preferences receiving the most empirical and theoretical attention. Although recent work has acknowledged the existence of male mate preferences, whether they have evolved and are maintained as a direct result of selection on males or indirectly as a genetically correlated response to selection for female choice remains an ope

Background: The ECG is important in the diagnosis and triage of the acute coronary syndrome (ACS), especially in the hyperacute phase, the "golden hours," during which myocardial salvage possibilities are largest. An important triaging decision to be taken is whether or not a patient requires primary PCI, for which, as mentioned in the guidelines, the presence of an ST elevation (STE) pattern in t

Abstract in UndeterminedA measure of coherence is said to be reliability conducive if and only if a higher degree of coherence (as measured) among testimonies implies a higher probability that the witnesses are reliable. Recently, it has been proved that several coherence measures proposed in the literature are reliability conducive in scenarios of equivalent testimonies (Olsson and Schubert 2007;

We report on the electronic structure of nano-crystalline Fe:ZnO, which has recently been found to be an efficient photocatalyst. Using resonant photoemission spectroscopy, we determine the binding energy of Fe 3d states corresponding to different valencies and coordination of the Fe atoms. The photo-activity of ZnO reduces Fe from 3+ to 2+ in the surface region of the nano-crystalline material du

This study investigated eyewitnesses’ memory and confidence accuracy for action information (what happened at the crime scene), and detail information (descriptions of persons, objects, time and place). In Experiment 1, 89 participants watched a film and participated in one of four conditions: Laboratory discussion, Family discussion, Retell and Control, the first three with five meetings each. Th

Abundant chromite grains with L-chondritic composition in the resurge deposits of the Lockne impact crater (458 Myr old: dia. similar to 10 km) in Sweden have been inferred to represent relict fragments of an impactor from the break-up of the L-chondrite parent body at 470 Ma. This view has been challenged based on It/Cr and platinum group element (PGE) patterns of the same resurge deposits, and a

In this work, a first-order upwind and a high-order flux-limiter schemes for solving the advection–diffusion equation on unstructured grids were evaluated. The numerical schemes were implemented as a module of an unstructured two-dimensional depth-averaged circulation model for shallow lakes (IPH-UnTRIM2D), and they were applied to the Guaíba River in Brazil. Their performances were evaluated by c

The quality of treatment with warfarin is mainly assessed by the time in therapeutic range (TTR) in patients with mechanical heart valve prosthesis (MHV). Our aim was to evaluate if International Normalized Ratio (INR) variability predicted a combined endpoint of thromboembolism, major bleeding and death better than TTR.

We present a new method for detecting fractures in solid materials below the resolution given by the detector pixel size by using grating-based X-ray interferometry. The technique is particularly useful for detecting sub-pixel cracks in large samples where the size of the sample is preventing high-resolution mu CT studies of the entire sample. The X-ray grating interferometer produces three distin

We hypothesized that CSF neurofilament light (NFL) levels would be elevated in dementias with subcortical involvement, including vascular dementia (VaD), but less elevated in dementias primarily affecting gray matter structures, such as Alzheimer disease (AD), and that elevated CSF NFL would correlate with disease severity and shorter survival time irrespective of clinical diagnosis.

It has been suggested that alcohol consumption is associated with increased risk of a few solid cancers, although studies that examined the association with hematological malignancies have shown inconsistent results. In this study, we examined the risk of hematological malignancies among individuals who had alcohol use disorders (AUDs) in Sweden.

Listeria monocytogenes is a Gram-positive facultative intracellular bacterium that causes life-threatening diseases in humans. It grows and survives in environments of low oxygen tension and under conditions of strict anaerobiosis. Oxygen-limiting conditions may be an important factor in determining its pathogenicity. L. monocytogenes serovar 1/2a strain EGD-e has been employed intensively to eluc

The behaviour of ice sheets and their geologic imprints in fjord regions are often multifaceted. Fjords, which were temporarily occupied by fast flowing ice-streams during major glaciations, and inter-fjord areas, which were covered by less active ice, show different signatures of past glaciations. The land and marine records of glaciations over the western Svalbard fjord region have been extensiv

Systemic infusions of angiotensin II (AngII) rapidly induce large, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor(s), AngII generates reactive oxygen species (ROS) and produces Ca(2+) influx into cells, leading to activation of a plethora of signaling cascades, including e.g. calcineurin, and small GTPases, such as Rac-1 and

Group B streptococcus (GBS) is a leading neonatal pathogen and a growing cause of invasive disease in the elderly, with clinical manifestations such as pneumonia and sepsis. Despite its clinical importance, little is known about innate immunity against GBS in humans. Here, we analyze the role of human group IIA secreted phospholipase A2 (sPLA2-IIA), a bactericidal enzyme induced during acute infla

Dietary fiber and flavonoids, important components in berries, are suggested to improve metabolic health. This study investigates whether soluble and insoluble fractions isolated from bilberry, black currant, and raspberry affect the formation of short-chain fatty acids (SCFAs), uptake and excretion of flavonoids, and levels of cholesterol differently. Cecal SCFA pools were higher in rats fed the