Popular Abstract in Swedish Den cancerskyddande genen p53 är av betydelse för att göra leukemiceller friska. Blodbildning. Blodceller är nödvändiga för vårt välbefinnande och vår överlevnad. Det finns flera olika typer med egna specialiserade funktioner. Så krävs t. ex. röda blodkroppar för syresättning och vita blodkroppar för att bekämpa infektioner. Blodcellerna har begränsad överlevnad; när Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. Differentiation of both leukemic and normal hematopoietic cells is believed to be intimately coupled to cell cycle

This paper presents an exploration algorithm which examines execution time and energy consumption of a given application, while considering a parameterized memory architecture. The input to our algorithm is an application given as an annotated task graph and a specification of a multi-layer memory architecture. The algorithm produces Pareto trade-off points representing different multi-objective e

Rigid, chiral and amphiphilic cyclophanes of potential use as biomimetic host molecules were prepared by cyclic dimerisation of chiral diamino building blocks with amino-reactive cross-linking reagents. A reliable synthesis of the scaffold 2,7-diaza-1,2,3,6,7,8-hexahydropyrene was developed. Chiral bidentate building blocks were formed by acylation of the aromatic diamine 2,7-diaza-1,2,3,6,7,8-hex

This volume explores in detail the empirical and conceptual content of the definiteness effect in grammar. It brings together a variety of relevant observations from a typological, diachronic and a bilingual/second language acquisition perspective, and provides a general overview of different approaches concerned with the syntactic, morphological, semantic, and pragmatic properties of the Definite

This paper presents the ongoing design and evaluation of an audio-haptic drawing program that allows visually impaired users to create and access graphical images. The application is developed in close collaboration with a user reference group of five blind/low vision school children. The objective of the application is twofold. It is used as a research vehicle to investigate user interaction tech

Popular Abstract in Swedish Hur ser vardagen ut för äldre demenssjuka människor? Vad händer när dementa och vårdbiträden dagligen möts i nära och intima relationer? Denna avhandling ger en ingående beskrivning av hur vardagen gestaltar sig på tre gruppboenden för dementa med utgångspunkt från hur dementa och vårdbiträden faktiskt handlar i olika situationer. Ett försök görs att ge ett förståelsepeThis thesis is about the residents and employees at three group homes for older people suffering from dementia. The empirical data comprises princi- pally of participant observation and interviews with caregivers. The aim of the dissertation is to describe and understand what happens during daily life at a group home for elderly suffering from dementia. The ambition is to understand the patterns o

Recent analyses have questioned the usefulness of heterozygosity estimates as measures of the inbreeding coefficient (f ), a finding that may have dramatic consequences for the management of endangered populations. We confirm that f and heterozygosity is poorly correlated in a wild and highly inbred wolf population. Yet, our data show that for each level of f, it was the most heterozygous wolves t

Fuel cells are promising for future energy systems, since they are energy efficient and, when hydrogen is used as fuel, there are no emissions of greenhouse gases. Fuel cells have during recent years various improvements, however the technology is still in the early phases of development, this can be noted by the lack of dominant design both for singe fuel cells, stacks and for entire fuel cell sy