Grapefruit-derived nootkatone potentiates GABAergic signaling and acts as a dual-action mosquito repellent and insecticide
Humanity has long battled mosquitoes and the diseases they transmit—a struggle intensified by climate change and globalization, which have expanded mosquito ranges and the spread of associated diseases.1 Additionally, widespread insecticide resistance has reduced the efficacy of current control methods, necessitating new solutions.2,3 Nootkatone, a natural compound found in grapefruit, shows promi