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Background: Smoking is a strong risk factor for the development of Graves’ ophthalmopathy (GO). Immediate early genes (IEGs) are overexpressed in patients with active GO compared to healthy controls. The aim of this study was to study the effects of tobacco smoking and simvastatin on preadipocytes and orbital fibroblasts (OFs) in the adipogenic process. Methods: Cigarette smoke extract (CSE) was g

The accuracy of the Mg/Ca paleothermometer is contested over the influences of secondary environmental parameters such as salinity and pH. Recent calibrations based on compiled sediment trap and laboratory culture data suggest moderate influences from salinity and pH. Core tops are the best analogues to downcore samples used for paleoceanographic reconstruction with well-constrained environmental

Temperaturändringar och krympning påverkar betongkonstruktioners volym, och i konstruktioner som hindras från av röra sig kan sådana volymändringar leda till så kallade tvångseffekter, som i sin tur kan orsaka sprickbildning. När detta sker kan emellertid konstruktionen deformeras till viss del, vilket gör att tvångsspänningarna och därmed också sprickvidderna minskar. Uppsprickningsförloppet är sThermal actions and shrinkage cause volume changes in concrete structures. In structures which are restrained from movements, the restraint effects can cause cracking. However, when cracking occurs, the structure can deform to some extent, which reduces the restraint stresses and thus also the crack widths. As the exact crack development is hard to predict beforehand, the actual restraint and thus

We have measured B/Ca in four core-top planktonic foraminiferal species (Globigerinoides ruber (white), Globigerinoides sacculifer (without final sac-like chamber), Neogloboquadrina dutertrei, and Pulleniatina obliquiloculata) from three depth transects (the Caribbean Sea, the southwestern Indian Ocean, and the Ontong Java Plateau) to evaluate the effect of dissolution on planktonic foraminiferal

With growing tourism in natural areas, monitoring recreational impacts is becoming increasingly important. This paper aims to evaluate how di_erent trampling intensities a_ect some common Icelandic plant communities by using digital photographs to analyze and quantify vegetation in experimental plots and to monitor vegetation recovery rates over a consecutive three-year period. Additionally, it se

Atmospheric CO2 concentrations declined markedly about 70,000 years ago, when the Earth's climate descended into the last glaciation. Much of the carbon removed from the atmosphere has been suspected to have entered the deep oceans, but evidence for increased carbon storage remains elusive. Here we use the B/Ca ratios of benthic foraminifera from several sites across the Atlantic Ocean to reconstr

Abstract: This data on the age of metamorphism of rocks of the Yelabuga zone and the geochronological data on detrital zircon from paragneisses of the same zone are presented, and their correlation with the ages of rocks from the Middle Volga megablock is made. The rocks of the Yelabuga zone and Middle Volga megablock have similar geochemical characteristics and degrees of metamorphism, but demons

During the Last Glacial Maximum (LGM; ~20,000 years ago), the global ocean sequestered a large amount of carbon lost from the atmosphere and terrestrial biosphere. Suppressed CO2 outgassing from the Southern Ocean is the prevailing explanation for this carbon sequestration. By contrast, the North Atlantic Ocean—a major conduit for atmospheric CO2 transport to the ocean interior via the overturning

Aim: Patient reported outcome measures (PROMs) quantify various domains of health related quality of life (HRQOL) from the patient perspective. The overall aim of this thesis was to investigate patient reported outcomes (PROs) in patients with cleft lip and/or palate (CL/P). Method: PROs were investigated in the CL/P population with PROMs and interviews. Health care professional (HCP) experience o

Ett kapitel baserat på forskning om personlig assistans och rätten för en människamed normbrytande funktion att utveckla en egen sexualitet, med diskussion om hur dessa svenska förhållanden förhåller sig till liknande frågor i andra länder.

Operation and maintenance (O&M) is highly important to fight unplanned downtime, which is a costly consequence of the increasing automation enabled by digitalization. We will discuss O&M to enable seamless exchange of information in a hierarchical multi-vendor system, while ensuring individual vendors controlling what know-how to share.

Narrow resonances decaying into W W, W Z or ZZ boson pairs are searched for in 139 fb−1 of proton-proton collision data at a centre-of-mass energy of s = 13 TeV recorded with the ATLAS detector at the Large Hadron Collider from 2015 to 2018. The diboson system is reconstructed using pairs of high transverse momentum, large-radius jets. These jets are built from a combination of calorimeter- and tr

In this work, we present measurements of the intensity-dependent photoelectron spectrum of Kr irradiated by the FLASH FEL tuned to a photon energy of 25.8 eV. Intensity dependent photoelectron spectra were obtained with the aid of a Velocity Map Imaging (VMI) spectrometer. As the FEL photon energy is close to threshold, two photon sequential double ionization is favoured. The number of open channe

OBJECTIVES: Alcohol use disorders (AUD) is well known to aggregate in families and is associated with socioeconomic status (SES). The objective was to study the effect of education, income and neighborhood SES in adulthood on AUD, and to explore whether the potential associations were confounded by shared familial factors, by using a co-relative control design. METHODS: Data on AUD was drawn from

In this paper we are proposing a new member in the SNOW family of stream ciphers, called SNOW-V. The motivation is to meet an industry demand of very high speed encryption in a virtualized environment, something that can be expected to be relevant in a future 5G mobile communication system. We are revising the SNOW 3G architecture to be competitive in such a pure software environment, making use o

This article historicises the nature of political transition in Myanmar to better appreciate the challenges faced by civil society. After Myanmar’s political reforms in 2011, Western donors rushed into the country in support of what they misunderstood as a remarkable instance of democratisation. In 2019, escalating civil war, ethnic cleansing, and contracting civil liberties urge a rethink. This a

Since its development in the 1990s, the Regional Innovation Systems (RIS) approach has attracted considerable attention from economic geographers, innovation scholars and policy makers. The RIS approach is well-known in scientific discourse about the uneven geography of innovation and the factors that shape the knowledge generation and innovation capacities of regions. The aim of this paper is to

The main premise of self-service business analytics (SSBA) is to make business users autonomous during data analytics. Driven by this potential, organizations are spending resources to design SSBA environmet to empower business employees and decentralize the analytics capabilities. Yet, little is known about how SSBA is facilitating business employees’ independence, and moreover, the value that is