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Cerebral microangiopathy in stroke-prone spontaneously hypertensive rats. An immunohistochemical and ultrastructural study

The morphology of cerebral microvessels was studied immunohistochemically and ultrastructurally in 6- to 9-month-old normotensive Wistar-Kyoto rats (WKY), spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP) with a systolic blood pressure of 138 +/- 15 mm Hg, 189 +/- 9 mm Hg, and 258 +/- 30 mm Hg respectively. Regions with major opening of the blood-brain barrier (BBB) were revealed

A double twin isothermal microcalorimeter

The design and properties of a double twin heat conduction microcalorimeter are described. In this instrument two twin microcalorimeters are placed close together, one on top of the other. The size of the instrument is the same as that of a commercial single twin microcalorimeter and each of the twin parts has similar properties as one normal twin microcalorimeter. The cross-talk between the calor

Tongue movement kinematics in long and short Japanese consonants

This paper examines tongue movements in stop and fricative consonants where the duration of the oral closure/constriction for the consonant is varied for linguistic purposes. Native speakers of Japanese served as subjects. The linguistic material consisted of Japanese word pairs that only differed in the duration of the lingual consonant, which was either long or short. Recordings were made of ton

About being (t)here and making a difference : Black women and the paradox of visibility

Feminists, like many others, want to make a difference. They are interested in social change. They are especially interested in the ways this concerns the position of women in our societies. In order to accomplish this, the different actors within the women’s movements of Europe must be present in the political arenas where decisions are made. This concerns white indigenous women, as well as Black

Decay of core excitations in bulk h-BN studied with resonant Auger spectroscopy

Non-radiative decay of core excitations at the B 1s and N 1s absorption edges of bulk hexagonal boron nitride (h-BN) has been studied with resonant Auger spectroscopy. In order to reproduce the bulk properties of the sample while keeping it electrically conducting, we have grown reasonably thick (more than 20nm) polycrystalline films of h-BN on a Ni(111) surface by thermal cracking of borazine vap

Urodynamic effects of a novel EP(1) receptor antagonist in normal rats and rats with bladder outlet obstruction.

Purpose: Prostaglandin E-2 and its EP1 receptor were suggested as endogenous modulators of bladder function in the normal physiological state and under pathophysiological conditions. We investigated if the new EP1 receptor antagonist PF-2907617-02 would influence the regulation of normal micturition in rats, and if it affects bladder function in animals with partial bladder outlet obstruction. Mat

Historical diversification of migration patterns in a passerine bird

Migratory strategies of birds require complex orientation mechanisms, morphological adaptations, and life-history adjustments. From an evolutionary perspective, it is important to know how fast this complex combination of traits can evolve. We analyzed mitochondrial control-region DNA sequences in 241 blackcaps (Sylvia atricapilla) from 12 populations with different migratory behaviors. The sample

Scaling up effects in the organic laboratory

A simple, yet safe and effective set of experiments to expose chemistry students to some of the effects that may be encountered when scaling up an organic reaction is described. The exothermic Diels–Alder reaction between maleic anhydride and cyclopentadiene was found to be ideal for our purposes and was performed in small, medium, and large scale for comparison. The observed differences of heat e

The Emergence of Conditional Subordinators in Swedish : A Study in Grammaticalization

This thesis is an empirical and theoretical study of the emergence of five Swedish conditional subordinators: utan, om, hvar, ifall and bara. The first changes occur in the 13th century, and the last in the 18th century. After a theoretical introduction, in which grammaticalization as well as conditionality and conditional structures are critically discussed, five paths of change are identified. T

Age-related increase in wall stress of the human abdominal aorta: An in vivo study

Background: The regulation of wall stress in the abdominal aorta (AA) of humans might be of specific interest, because the AA is the most common site for aneurysm formation in which wall stress seems to be an important pathophysiological factor. We studied the age-related changes in wall stress of the AA in healthy subjects, with the common carotid artery (CCA) as a comparison. Methods. A total of

An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione

Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (IR, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.