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The title aldehydes (lr, 1s, 2, and 3) underwent virtually diastereospecific conjugate addition by lithium methylcyanocuprate. The bulkiness of the anomeric benzyloxy or methoxy groups direct the attacking nucleophile to the less hindered side of the furanosidic ring. The stereochemical outcome of the Diels-Alder additions of cyclopentadiene to lr and 1s was governed almost completely by the bulki
Baker's yeast phosphatases induced regioselective hydrolysis on phytic acid leading to D-myo-inositol 1,2,6-tris(phosphate) which was transformed in optically active (+)-D-3,4,5-tri-O-phenylcarbamoyl-myo-inositol.
4-Deoxy-4-fluoro-myo-inositol was prepared by means of DAST with retention of configuration due to the assistance of a neighbouring benzyl ether.
Connected Autonomous Vehicles (AVs) with Vehicle-to-Vehicle (V2V) communication are becoming an essential component of the transportation system. Self-driving cars have the potential to optimize the roads' traffic flow, fuel consumption and remove the possibility of human error and distractions. In these systems, all involved vehicles must be fully autonomous for maximum gain. However, a fully aut
Phosphorylation of 6-O-tritylated methyl α-D-mannopyranosidc followed by deprotection gives an analogue of α-trinositol having virtually similar orientation of the phosphate groups. Biological testing showed the analogue to be inferior with respect to pharmacological effects.
BackgroundEven when palliative care is an integrated part of the healthcare system, the quality is still substandard for many patients and often initiated too late. There is a lack of structured guidelines for identifying and caring for patients; in particular for those with early palliative care needs. A care guide can act as a compass for best practice and support the care of patients throughout
Periodate oxidation of 1D-myo-inositol 1,2,6-trisphosphate pentasodium salt (α-trinositol) gives the expected cyclic D-arabino-pentodialdose as a mixture of anomers. Reaction with a primary amine and subsequent reduction with sodium borohydride gives the title compounds.
The acylation of α-trinositol is very sensitive to reaction conditions. Competing condensation reactions may give pyrophosphates and cyclic phosphates. Treatment of a tert-ammonium salt corresponding to α-trinositol with carboxylic acid anhydride and DMAP gives a good yield of the expected esters.
Acyloxymethylation of an acylated silver salt of α-trinositol gives, after deprotection, membrane permeable 1D-myo-inositol 1,2,6-tris(ethoxycarbonyloxymethyl sodium phosphate). The acyl groups, 3-(4,5-methylenedioxy-2-nitrophenyl)propanoyl, are cleaved by hydrogenolysis.
Acylation of 1D-myo-inositol 1,2,6-trisphosphate (α-trinositol) followed by alkylation of the phosphate groups with benzyl bromoacetate or 2-benzyloxyethyl iodide and deprotection provides a route to analogues with modified phosphate groups. The modifications made alter steric and ionisation properties but the possibility to participate in hydrogen bonding and ionic interaction is retained.
Phytic acid treated with Baker's yeast gave D-myo-inositol-1,2,6-tris(phosphate) (α-trinositol) which was transformed into (+)-D-1,2-O-isopropylidene-myo-inositol and (-)-D-4,5-tri- O-benzyl-myo-inositol, two key intermediates in the synthesis of optically active myo-inositol derivatives and related compounds.
The reaction of perbenzylated (±)-myo-inositol 1,2-bis- and 1,2,6-tris-phosphites with benzyl bromoacetate, followed by catalytic (Pd/C) hydrogenolysis affords (±)-myo-inositol 1,2-bis- and 1,2,6-tris(carboxymethylphosphonate). The same procedure is used for the synthesis methyl α-D-mannopyranoside 2,3,4-tris(carboxymethylphosphonate).
α-Trinositol analogues, including methyl ethers, deoxy, oxa and aza derivatives were prepared. The parent compound possesses weak analgesic and anti-inflammatory properties. Removal of the non-phosphorylated hydroxyls generates a compound devoid of analgesic activity but which retains the anti-inflammatory property of the parent compound. The protection of these hydroxyls as methyl ethers lends to
D-(-)-Quinic acid was appropriately protected to permit the phosphorylation of the three vicinal hydroxyl groups. Final deprotection lead to tris(phosphates) possessing the same configuration as the parent α-trinositol and an arm suitable for the attachement of a photoactivable group.
Language and different sexual health discourses constitute barriers to the uptake of information on sexual and reproductive health and rights among migrants. Challenges remain with regards to the design and implementation of culturally appropriate programmes and interventions. This study explored the role of civic communicators in increasing access to sexual health information among migrants reset
Benzylidene protected bis-MPA, 2,2-bis(hydroxymethyl)propanoic acid, was synthesised and evaluated as building block in the construction of dendrimers. It was found that the anhydride of benzylidene protected bis-MPA reacts with neopentylic alcohols to give high yields of acylated products. Purification is facilitated by the crystalline nature of most ester products. Deprotection by hydrogenolysis
The use of hyperbranched polymers (HBPs) as a processing aid for linear low density polyethylene (LLDPE) was investigated. Various generation (or pseudo-generation) HBPs were used which had either 16 carbon atom alkanes or a mixture of 20/22 carbon atom alkanes on the end groups. In addition, the degree of end group substitution was studied. Blends of up to 10% HBP content were mixed via extrusion
This paper uses the notion of material affordances to show that a focus on how people engage with materials helps understanding how organizations transit toward sustainability. Material affordances refer to the enablements and constraints afforded by materials to someone engaging with an environment for a particular purpose. Based on a qualitative study of a company's efforts at becoming circular,
