Genetic variations are investigated in human and many other organisms for many purposes (e.g., to aid in clinical diagnosis). Interpretation of the identified variations can be challenging. Although some dedicated prediction methods have been developed and some tools for human variants can also be used for other organisms, the performance and species range have been limited. We developed a novel v

Motivated by the intriguing physics of quasi-two-dimensional fermionic systems, such as high-temperature superconducting oxides, layered transition metal chalcogenides, or surface or interface systems, the development of many-body computational methods geared at including both local and nonlocal electronic correlations has become a rapidly evolving field. It has been realized, however, that the su

The dynamics of the human body can be described by the accelerations and masses of the different body parts (e.g., legs, arm, trunk). These body parts can exhibit specific coordination patterns with each other. In human walking, we found that the swing leg cooperates with the upper body and the stance leg in different ways (e.g., in-phase and out-of-phase in vertical and horizontal directions, res

Background: [18F]PSMA-1007 is a promising tracer for integrated positron emission tomography and computed tomography (PET/CT). Objective: Our aim was to assess the diagnostic accuracy of [18F]PSMA-1007 PET/CT for primary staging of lymph node metastasis before robotic-assisted laparoscopy (RALP) with extended lymph node dissection (ePLND). Design, Setting and Participants: The study was a retrospe

Objective Data from the Paralympic Games indicate a fluctuating injury incidence in the Paralympic sport Goalball, but the mechanisms behind have not been explored. The aims of this study were to; i) quantitatively analyze Goalball injuries reported in the London 2012 and Rio 2016 Paralympic Games, ii) qualitatively explain the differences between both Games, and iii) qualitatively assess general

Background: The influencing factors of kinesiophobia (fear of movement) in patients with atrial fibrillation(AF)during the post-operative “Blanking Period” are not known. The aims were to investigate the status of kinesiophobia in patients with AF during the post-operative “Blanking Period”, then further describe the occurrence and analyze the influencing factors of patients' kinesiophobia by the

Public and private policies typically consider the construction of infrastructure the most appropriate response to the problems of water scarcity and water disputes. However, infrastructure in itself not always is the solution. In this context we have the following questions: What are the logics behind the construction and implementation of water infrastructure? Why water infrastructures are not a

The expansion of large-scale mining projects in Latin America has led to the application of several different institutional and business-endorsed water monitoring systems. These have attempted to deal with their vast environmental consequences. The methods are based on the devaluation of other forms of knowledge. As a response to this tendency, community hydric monitoring (MHC in Spanish) has been

The phenomena of landgrabbing and monopolizing of water sources have gained increasing attention in recent years. Nevertheless, very few studies have dealt with the problem of the grabbing and concentration of resources from an ethnographic perspective that would make it possible to illustrate the different ways in which dispossession takes place, as well as its concrete mechanisms and effects in

This paper presents the numerical results of combustion and soot recession in the Engine Combustion Network (ECN) Spray A and D flames using large eddy simulations (LES). The nominal injector nozzle diameters for the ECN Spray A and D are 90μm and 186μm. A two-equation soot model is implemented to model the soot formation and oxidation processes. The numerical model is validated by comparing the s

Purpose of Review: Producing wood of the right quality is an important part of forest management. In the same way that forest growth models are valuable decision support tools for producing desired yields, models that predict wood quality in standing trees should assist forest managers to make quality-influenced decisions. A challenge for wood quality (WQ) models is to predict the properties of po

Purpose: Malignant breast lesions can be distinguished from benign lesions by their mechanical properties. This has been utilized for mechanical imaging in which the stress distribution over the breast is measured. Mechanical imaging has shown the ability to identify benign or normal cases and to reduce the number of false positives from mammography screening. Our aim was to develop a model of mec

The volcanic island of Jan Mayen, located in the Norwegian – Greenland Sea, has very few lake basins out of which only one, Lake Nordlaguna, holds a permanent lake throughout the year. The island is volcanic and has been glaciated, but the lake basin is not genetically typical for volcanic crater lakes or other common types of volcanic lakes. Nor is it typical for ice-scoured glacial lakes. Instea

Background: Systemic sclerosis (SSc) can lead to visible changes in appearance which could generate concerns among patients. Thus, valid questionnaires that capture these concerns are valuable to identify and communicate appearance concerns. Objective: To determine aspects of the validity and reliability of the Swedish version of the Satisfaction with Appearance scale for individuals with SSc (SWA

Universities are powerful drivers to create and advance knowledge on sustainable development. Furthermore, they can be used as a controlled environment to apply innovative technologies and approaches. This process also embraces industry and government, in the triple helix innovation model, as in the University of Campinas (Unicamp), Brazil—one of the best Latin American universities (3rd)—and imme

Valved conduit reconstruction between the right ventricle (RV) and the pulmonary circulation is often necessary in the surgical treatment of complex congenital heart defects. The aim of this study is to evaluate the long-term performance of the three types of conduits we have used and assess risk factors for conduit failure. Retrospective, single-center review of 455 consecutive pediatric patients