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The Case for a Broader Approach to e-Participation Research: Hybridity, Isolation and System Orientation

Two decades into the young history of e-participation research, we aim to take stock of the state of this field in the light of three developments that we argue have substantial implications for research on electronic participation:(1) dissolving boundaries between online and offline spheres of political participation;(2) academic isolation of e-participation research from other research fields re

Interpreting biologically informed neural networks for enhanced proteomic biomarker discovery and pathway analysis

The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from lack of interpretability. Here, we present a deep learning approach to combine biological pathway analysis and biomarker identification to increase the interp

Acceptorless dehydrogenation of 4-methylpiperidine by supported pincer-ligated iridium catalysts in continuous flow

Finding alternative and sustainable ways to produce, store and convert energy is key for reducing fossil fuel-based CO2 emissions. In this transformation, hydrogen for energy storage and hydrogen-powered fuel cells for energy conversion can play important roles. However, storage of hydrogen itself is difficult and the concept of reversible liquid organic hydrogen carriers (LOHCs) has been proposed

The Rubber Hand Illusion evaluated using different stimulation modalities

Tactile feedback plays a vital role in inducing ownership and improving motor control of prosthetic hands. However, commercially available prosthetic hands typically do not provide tactile feedback and because of that the prosthetic user must rely on visual input to adjust the grip. The classical rubber hand illusion (RHI) where a brush is stroking the rubber hand, and the user's hidden hand synch

Solidarity Through the Lens of Functional Constitutionalism

This article investigates solidarity as a concept and/or a norm of EU law from the perspective of functional constitutionalism. It asks how solidarity fits within the normative framework of the EU legal order if we understand this framework as being founded on a functional constitution.Under functional constitutionalism, the EU is understood as a purposive polity and the authority of the legal ord

Protecting the Free Speech of Companies? : The US Supreme Court Decision in 303 Creative LLC v Elenis

In 303 Creative LLC et al. v Elenis, the US Supreme Court held that the petitioners were entitled to refuse to provide wedding website services in respect of same sex weddings, and to post a notice on their website stating that they would not provide such services.The case was framed as concerning the freedom of speech of the website designer (Ms Lorie Smith), although the main petitioner was not

Activity fingerprinting of AMR β-lactamase towards a fast and accurate diagnosis

Antibiotic resistance has become a serious threat to global public health and economic development. Rapid and accurate identification of a patient status for antimicrobial resistance (AMR) are urgently needed in clinical diagnosis. Here we describe the development of an assay method for activity fingerprinting of AMR β-lactamases using panels of 7 β-lactam antibiotics in 35 min. New Deli Metallo β

The dynamics of red blood cells and iron status during infancy

Red blood cell (RBC) and iron status biomarkers are commonly used in clinical diagnostics. However, interpretations of infant test results are inherently challenging. Modern well-defined comparative data based on presumably healthy term-born infants have mainly been lacking and interpretations could be further complicated by interference from frequent infections. Moreover, the trends that follow w

Prenatal exposure to phthalates and gender-specific play behavior at seven years of age in the SELMA study

Background: A growing body of evidence shows that prenatal exposure to phthalates affects child development. Since many phthalates have been shown to alter endocrine signaling, they may influence reproductive development, neurodevelopment, and child behavior. Indeed, a few studies reported associations between prenatal phthalate exposure and gender-specific play behavior. However, evidence for thi

Nuclear Magnetic Resonance Studies of Bicontinuous Liquid Crystalline Phases of Cubic Symmetry : Transport Properties from 2H Nuclear Magnetic Resonance Relaxation Rates

The ternary system didodecyltrimethylammonium bromide, 1-decanol, and water forms an extended reversed continuous phase of cubic symmetry at 25 °C. The cubic phase belongs to the space group Im3m, as shown by small-angle X-ray experiments. We present extensive deuterium NMR relaxation data from this cubic phase for 1-decanol, deuterated at the carbon adjacent to the hydroxyl carbon position. 2H sp

LEAPS data strategy

The continuous evolution of photon sources and their instrumentation enables more and new scientific endeavors at ever increasing pace. This technological evolution is accompanied by an exponential growth of data volumes of increasing complexity, which must be addressed by maximizing efficiency of scientific experiments and automation of workflows covering the entire data lifecycle, aiming to redu

Sex and gender in infection and immunity : addressing the bottlenecks from basic science to public health and clinical applications

Although sex and gender are recognized as major determinants of health and immunity, their role is rarely considered in clinical practice and public health. We identified six bottlenecks preventing the inclusion of sex and gender considerations from basic science to clinical practice, precision medicine and public health policies. (i) A terminology-related bottleneck, linked to the definitions of

Neuronal activity dynamics in the dentate gyrus during early epileptogenesis

Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in p

Cirkulär ekonomi : ett levande och lärande kulturarv?

In recent years, the term circular economy has become central in both research and politics. Inmost writings and policy documents, a circular economy is assumed to presuppose a break fromprevious habits and practices. Cultural and historical perspectives are often neglected, eventhough most preindustrial agriculture and food systems developed methods for the circulationand recycling of resources.