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Reproductive Factors and Breast Cancer - Parity, Breastfeeding and Genetic Predisposition in Relation to Risk and Prognosis

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen hos kvinnor världen över och den står för omkring 30% av all cancer hos kvinnor i Sverige. Varje år får ca 7000 kvinnor i Sverige diagnosen och man räknar att ca en av tio kvinnor insjuknar under sin livstid. Trots att så många får bröstcancer så är det betydligt färre kvinnor som dör av bröstcancer; för närvarande ca 1500 per The aim of this thesis was to study reproductive factors and genetic polymorphisms in relation to breast cancer risk and survival. An important component of this was to investigate the risk of specific breast cancer subgroups. The association between parity and breast cancer-specific survival was studied among 4,453 women diagnosed with breast cancer in Malmö, Sweden. It was found that: • Nullipar

Paper-thin walls: Law and the domestic in Marie Belloc Lowndes’ popular gothic

Marie Belloc Lowndes was a prolific author, publishing over forty novels in addition to plays, memoirs and a large number of short stories spanning the first five decades of the twentieth century. Most of these are now largely forgotten. Despite her obvious popularity, evidenced by a significant number of film adaptations of her novels, Lowndes has not yet reached the radar of literary studies. Th

Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke.

Activation of the sigma-1 receptor (Sig-1R) improves functional recovery in models of experimental stroke and is known to modulate microglia function. The present study was conducted to investigate if Sig-1R activation after experimental stroke affects mediators of the inflammatory response in the ischemic hemisphere. Male Wistar rats were subjected to transient occlusion of the middle cerebral ar

Systolic blood pressure and risk of cardiovascular diseases in type 2 diabetes: an observational study from the Swedish national diabetes register.

OBJECTIVES: To estimate risks of fatal/nonfatal coronary heart disease (CHD), stroke and cardiovascular disease (CVD) with SBP in an observational study of patients with type 2 diabetes. METHODS: Twelve thousand, six hundred and seventy-seven patients aged 30-75 years, treated with antihypertensive drugs, without previous congestive heart failure, followed for 5 years. RESULTS: Risk curves of CHD

Incidence and risk factors for low trauma fractures in men with prostate cancer.

BACKGROUND: Men with prostate cancer on androgen deprivation therapy (ADT) are at increased risk of bone loss. The present study sought to determine the incidence of low trauma fracture in men with prostate cancer (PC), and to characterize the association between potential risk factors and fracture risk in these men. METHODS: In the prospective, population-based Dubbo Osteoporosis Epidemiology Stu