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Specific binding of aldosterone by crude membrane fraction, the affinity and maximal concentration of cytosolic receptors of aldosterone were studied in the kidney cortex of the Wistar rats as well as the plasma level and adrenal biosynthesis of aldosterone. The specific binding of aldosterone was found to increase in membrane fraction and to decrease in cytosol during kidney maturation. The affin
The effect of aldosterone on the cAMP level, the state of inositol-phosphate pool and the intracellular free Ca2+ activity in the rat kidney, were studied. The cAMP level in the kidney cortex homogenate was not changed after i.p. injection of aldosterone. Reliable changes in the content of inositol-phosphates in the kidney cell suspension was not revealed after aldosterone treatment. A short-term
The aldosterone binding in isolated distal convoluted and cortical collecting tubules of renal nephrons and the influence of hormonal induction on the Na, K-ATPase activity in membrane fraction of kidney cortex were studied in 10-day- and 2-month-old rats. No reliable difference in aldosterone-specific binding was revealed (0.26 +/- 0.04 and 0.22 +/- 0.03 fmol/mm of tubule length, respectively, at
Effects of aldosterone and vasopressin on the intracellular Ca2+ activity in the isolated cortical collecting tubules were studied. Both aldosterone and vasopressin were shown to evoke a transient increase in intracellular Ca2+, the response amplitude being not reduced in the presence of the other hormones. As vasopressin via its membrane receptors, aldosterone is suggested to activate the system
The lytic polysaccharide monooxygenase (LPMO) enzymes boost polysaccharide depolymerization through oxidative chemistry, which has fueled the hope for more energy-efficient production of biofuel. We have recently proposed a mechanism for the oxidation of the polysaccharide substrate (E. D. Hedegård and U. Ryde, Chem. Sci., 2018, 9, 3866-3880). In this mechanism, intermediates with superoxide, oxyl
In this work, the new ANO-R basis set for all elements of the first six periods is introduced. The ANO-R basis set is an all-electron basis set that was constructed including scalar-relativistic effects of the exact-two component (X2C) Hamiltonian and modeling the atomic nucleus by a Gaussian charge distribution, which makes the basis set suitable for calculations of both light and heavy elements.
INTRODUCTION: Falls in older aged adults are an important public health problem. Insight into differences in fall-related injury rates between countries can serve as important input for identifying and evaluating prevention strategies. The objectives of this study were to compare Global Burden of Disease (GBD) 2017 estimates on incidence, mortality and disability-adjusted life years (DALYs) due to
Mergers of neutron stars (NS) and white dwarfs (WD) may give rise to observable explosive transientevents. We use 3D hydrodynamical (SPH) simulations, as well as 2D hydrodynamical-thermonuclearsimulations (using the FLASH AMR code) to model the disruption of CO-WDs by NSs, whichproduce faint transient events. We post-process the simulations using a large nuclear network andmake use of the SuperNu
This article investigates the reception of Swedish broadside songs dealing with wonders and accidents from the seventeenth and eighteenth centuries. Focusing on rhetorical strategies, the study suggests that these broadside ballads were designed to function as the basis for Lutheran meditation. The wonders and accidents are interpreted as the divine words of God, and the shocking images are used t
Artikelförfattaren gör en kronologisk genomgång av järtecken och historiska händelser med anknytning till Estland och Livland i kyrkoherden Joen Klints handskrivna Järteckenbok (bevarad i Linköpings Stiftsbibliotek). Klints anteckningar relateras till samtida idéhorisont (särskilt till Balthasar Russows livländska krönika, vilken tjänat som källa till en stor del av Klints anteckningar) och den mo
Despite significant interest in regional industrial restructuring in economic geography, surprisingly, scarce attention has been paid to the changing role of agency over time. The current paper develops a framework for understanding the role of multiple types of actors and the agency they exercise for regional industrial path development. The framework is employed in a longitudinal study of indust
The Gram-positive anaerobic commensal Finegoldia magna colonizes the skin and other non-sterile body surfaces, and is an important opportunistic pathogen. Here we analyzed the effect of F. magna on human primary neutrophils. F. magna strains ALB8 (expressing protein FAF), 312 (expressing protein L) and 505 (naturally lacking both protein FAF and L) as well as their associated proteins activate neu
