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Popular Abstract in Swedish This thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. The second part of the thesis deals with how embryonic stem cellsThis thesis includes two different parts: One focusing on how to induce human embryonic stem cells (hESCs) to differentiate into insulin producing cells by following the normal pancreatic development pathway. These cells have then the potential to be an unlimited source for diabetes regenerative medicine. The second part of the thesis deals with how embryonic stem cells rid themselves of damaged p

Creutzfeldt–Jakobs sjukdom är en prionsjukdom som kännetecknas av snabbt progredierande neurodegeneration, som leder till döden inom månader till något år. Eftersom sjukdomen är överförbar är den sedan 1998 anmälningspliktig enligt Smittskyddslagen. Den heterogena symtombilden, särskilt tidigt i sjukdomsförloppet, gör utredningen av misstänkta fall svår. Säkra diagnostiska metoder för att bekräftCreutzfeldt-Jakob disease (CJD) is a prion disease characterized by rapid neurodegeneration that leads to the death of the patient within months to a few years. Since the disease is transmissible, there is an obligation in Sweden to report possible CJD cases to the Swedish Institute for Infectious Disease Control. To make a diagnosis of CJD is difficult, especially early in the course of the disea

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Popular Abstract in Swedish ”Behandlingen av trafikflöde vid trafiksäkerhetsanalyser - ett icke-parametriskt angreppssätt applicerat på oskyddade trafikanter” Det finns en lång tradition av att beakta trafikflöden inom trafiksäkerhetsområdet. Inverkan av flödet har dock ofta betraktats som så självklart att det använts utan eftertanke. I denna avhandling kan jag däremot visa att relationen mellaThe treatment of flow in the area of traffic safety has a long tradition. The influence flow has on the number of accidents is, however, often considered so obvious that it tends to be trivial. In this thesis I can show that the relation between flow and accidents holds interesting information. In order to compare countermeasures, or conduct other types of traffic safety comparisons where the flo

Coreceptor use was determined for human immunodeficiency virus type 1 (HIV-1) isolates of various subtypes from 11 women during pregnancy and their infected children. Isolates from peripheral blood mononuclear cells (n = 79) and from plasma (n = 59) were available. The clinical and immunological stages of HIV-1 infection were recorded. Coreceptor use was tested on human cell lines expressing CD4 a

OBJECTIVE: To assess the 2-yr costs of extremely low birthweight infants' (ELBWIs; birthweight, < 1000 g) care in relation to birthweight, outcome, and the costs of normal birthweight infants. DESIGN: Cost data were obtained from care-giving hospitals and by a parental questionnaire. Outcome data from the perinatal and neonatal periods and from the first 2 yrs for both ELBWIs and control infants h

We present measurements of the potential profile of etched GaInAs/InP billiards and show that their energy gradients are an order of magnitude steeper than those of surface-gated GaAs/AlGaAs billiards. Previously observed in GaAs/AlGaAs billiards, fractal conductance fluctuations are predicted to be critically sensitive to the billiard profile. Here we show that, despite the increase in energy gra

BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) is associated with high risks for colorectal and endometrial cancer, young age at onset and an increased risk of multiple primary tumours. Colorectal cancer in HNPCC is characterised by poor tumour differentiation, an expanding growth pattern, and a pronounced lymphocytic reaction with tumour-infiltrating lymphocytes. Aims and METHODS:

Both the Fe II UV emission in the 2000-3000 Å region [Fe II(UV)]and resonance emission line complex of Mg II at 2800 Å areprominent features in quasar spectra. The observed Fe II(UV)/Mg IIemission ratios have been proposed as means to measure the buildup ofthe Fe abundance relative to that of the alpha-elements C, N, O, Ne,and Mg as a function of redshift. The current observed ratios show largesca

BACKGROUND: Oxazolone-induced colitis in the rat is an immune-driven model of human colitis. The aim of the present study was to measure the changes in the absorptive and exudative permeabilites, oedema formation, and local blood flow in this model during the development of inflammation. We also assessed the effects of acute (<1 h), topical glucocorticosteroid (GCS) treatment on these factors. MET

While working on a check-list of the Swedish species of Hieracium L. sect. Hieracium and H. sect. Vulgata (Griseb.) Willk. & Lange (now available at www.nrm.se/fbo/chk/ttlista/welcome.htmi), I found that three of the names in current usage were illegitimate, two being later homonyms and one superfluous when published. In this paper avowed substitutes (replacement names) for these names are pro

In this paper we outline a method for systematically addressing needs assessment (QUALISEM-PEOPLE), alongside a case study of its use within a medium sized, German company. The method was designed in order to provide guidance in analysing skill and role competences, particularly when e-learning systems are being considered for training purposes. The method proved to be successful within the compan

Abstract is not available

We have written a Fortran program BCVEGPY, which is an event generator for the hadronic production of the B-c meson through the dominant hard subprocess gg --> B-c(B-c(*)) + b + c. To achieve a compact program, we have written the amplitude of the subprocess with the particle helicity technique and made it as symmetric as possible, by decomposing the gluon self couplings and then applying the symm