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Parkinson´s disease is characterized by the accumulation of proteinaceous aggregates in Lewy bodies and Lewy Neurites. The main component found in such aggregates is α-synuclein. Here, we investigate how bovine eye lens crystallin proteins influence the aggregation kinetics of α-synuclein at mildly acidic pH (5.5) where the underlying aggregation mechanism of this protein is dominated by secondary

Background: Beside the pulmonary vasoconstriction observed in pulmonary arterial hypertension (PAH), severe proliferative and antiapoptotic cellular phenotypes result in vascular remodelling. Many recent findings indicate similarities between PAH and tumour pathology. For instance, insulin-like growth factor (IGF)-1 signalling, which is known to promote tumour development, is implicated in PAH. Hi

III-nitrides are considered the material of choice for light-emitting diodes (LEDs) and lasers in the visible to ultraviolet spectral range. The development is hampered by lattice and thermal mismatch between the nitride layers and the growth substrate leading to high dislocation densities. In order to overcome the issue, efforts have gone into selected area growth of nanowires (NWs), using their

The Swedish State Institute for Race Biology (SIRB) was founded in 1921 and immediately became the most important institution for racial science in Sweden. We know a great deal about the history of SIRB until 1935, when right-wing director Herman Lundborg retired and was replaced by the left-wing, anti-fascist Gunnar Dahlberg. In this essay, the later history of SIRB is for the first time examined

Little is known about the initial disclosure process when victims of domestic abuse break their silence and tell family, friends, neighbours or colleagues. This study draws on interviews with 21 Swedish women and analyses the interactional and emotional processes of the first disclosure. Shame, perpetrator threats, child custody issues, fear over increased/expanded violence, and how disclosure wil

Purpose: The influence of allograft ischemic time (IT) on short- and long-term mortality remains under debate in lung transplantation (LTx). Due to a scarcity in donors, better understanding of IT might improve the outcome after LTx. Methods: Between January 1990 and June 2016; 307 patients underwent LTx at Lund university hospital, Sweden. The end-point used was death/Re-LTx assessed by Cox regre

Purpose: In this study, we have quantified the setup deviation and time gain when using fast surface scanning for daily setup/positioning with weekly megavoltage computed tomography (MVCT) and compared it to daily MVCT. Methods: A total of 16 835 treatment fractions were analyzed, treated, and positioned using our TomoTherapy HD (Accuray Inc., Madison, USA) installed with a Sentinel optical surfac

Objective: The suggested link between major depression disorder (MDD) and blood–brain barrier (BBB) alterations supports an impact on the neurovascular unit in this disease condition. Here we investigate how pericytes, a major component in the neurovascular unit, respond to stress, stress hormones, proinflammatory cytokine and depression. Method: Hippocampal sections of chronic unpredictable stres

The extreme environments within the biosphere are inhabited by organisms known as extremophiles. Lately, these organisms are attracting a great deal of interest from researchers and industrialists. The motive behind this attraction is mainly related to the desire for new and efficient products of biotechnological importance and human curiosity of understanding nature. Organisms living in common “h

Concrete is one of the most commonly used building materials ever used. Despite it is a very important and common construction material, concrete is very sensitive to crack formation and requires repair. A variety of chemical-based techniques and materials have been developed to repair concrete cracks. Although the use of these chemical-based repair systems are the best commercially available choi

Several neurodegenerative diseases cause loss of cortical neurons, leading to sensory, motor, and cognitive impairments. Studies in different animal models have raised the possibility that transplantation of human cortical neuronal progenitors, generated from pluripotent stem cells, might be developed into a novel therapeutic strategy for disorders affecting cerebral cortex. For example, we have s

This licentiate-thesis, Stories About a red Cottage, is an attempt to combine cultural theory with a didactic method applied to Swedish as a field of study. With the two notions intertextuality and the foreign as a starting point, I discuss the importance of how an idyllic view of Sweden affects students studying Swedish as a foreign language as part of their studies in Scandinavistics. The studenThis licentiate-thesis, Stories About a red Cottage, is an attempt to combine cultural theory with a didactic method applied to Swedish as a field of study. With the two notions intertextuality and the foreign as a starting point, I discuss the importance of how an idyllic view of Sweden affects students studying Swedish as a foreign language as part of their studies in Scandinavistics. The studen

Low rank structures are present in many applications of computer vision and machine learning. A popular approach consists of explicitly parameterising the set or matrices with sought rank, leading to a bilinear factorisation, reducing the problem to find the bilinear factors. While such an approach can be efficiently implemented using second-order methods, such as Levenberg-Marquardt (LM) or Varia

We present a simple reduction of the problem of nondecreasing paths (with minimal last edge weight) in a directed edge-weighted graph to a reachability problem in a directed unweighted graph. The reduction yields an alternative simple method of solving the single-source nondecreasing paths problem in almost linear time. If the edge weights are integers then our algorithm can be implemented in O((n

During whey powder production, the feed is subjected to several heat treatments which can cause lactosylation of proteins. In this study, lactosylation of whey proteins was evaluated in spray-dried powders before and after storage by varying the native protein fraction as well as the serum protein/lactose ratio in the powders. The lactosylation of native α-lactalbumin and β-lactoglobulin in the po

The article investigates social learning of doping among elite athletes, based on qualitative interviews with 10 former competitive powerlifters, which were analyzed with Lave and Wenger’s learning theories. The constitution of the social context–the sports community–and specific situations were decisive for how the informants acted in relation to doping. The informants were situated in a powerlif

Background: The aim of this study was to investigate differences in clinical features and HLA genotypes between adult-onset and childhood-onset patients with type 1 diabetes in a Chinese population. Materials and Methods: This study enrolled 716 Han Chinese patients with type 1 diabetes from Guangdong (258 childhood-onset and 458 adult-onset) to compare their clinical features. Of them 214 patient

Activated factor XI (FXIa) inhibitors are anticipated to combine anticoagulant and profibrinolytic effects with a low bleeding risk. This motivated a structure aided fragment based lead generation campaign to create novel FXIa inhibitor leads. A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identifica