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OBJECTIVE Methylglyoxal (MGO), a reactive aldehyde forming advanced glycation end products (AGEs), is increased in diabetes and recognized by the immune system, resulting in anti-AGE-specific autoantibodies. The association of these immune responses with macro- and microvascular complications in type 1 diabetes remains unclarified. We investigated associations between MGO-modified apolipoprotein B

A Transverse Resonance Island Bucket optics has a betatron tune close to a resonance, such that the particle motion is governed by non-linear terms in the equation of motion. This results in additional stable fixed points in transverse phase-space, which can be populated with a single RF-bunch filling pattern. Thus, these optics have the potential of providing pseudo single-bunch operation, i.e. a

A novel combination of advanced gas-chromatography and detection systems coupled to a buffer-gas cell was characterized on-line to allow gas-phase chemical studies of accelerator-produced short-lived α-decaying mercury, francium, and astatine isotopes. These were produced in 40Ar- and 48Ca-induced nuclear fusion–evaporation reactions, subsequently isolated in the recoil separators MARS at Texas A&

Osteoarthritis (OA) remains the most challenging arthritic disorder, with a high burden of disease and no available disease-modifying treatments. Symptomatic early-stage OA of the knee (the focus of this Review) urgently needs to be identified and defined, as efficient early-stage case finding and diagnosis in primary care would enable health-care providers to proactively and substantially reduce

This paper analyzes the effect of being exposed to forced migration during childhood (ages 0-5) on educational achievement at age 15 (grade 9). Using register data from the Swedish Interdisciplinary Panel, I identify children who migrated to Sweden as a consequence of the rising conflict during the disintegration of the former Yugoslavia, and follow them until age 15, when they received their grades

This article studies the fast fossil fuel transition in the context of steam adoption in the Czech lands. I show how geographical proximity to coal brought forward the early industrialization of the Czech lands. The region’s fast transition to modern fuels fundamentally transformed the industrial landscape and laid foundations for the development of new industries. Coal, steam and sugar became the

We study the comprehension, mapping, and reporting of climate-related risks among firms listed on the NasdaqOMX stock exchange in Stockholm. Our study contains two parts: i) a study on the firms’ external communication through their annual reports, sustainability reports and webpages, and ii) a follow-up survey addressed to each firm’s management team. We find that firms are likely to engage in so

Begonia, belonging to the family Begoniaceae, is one of the largest Angiosperm genera with a pan-tropical distribution. Northeastern India shows a high degree of endemism with several endemic species described from the region. Begonia dicressine, so far known from Myanmar, has been recorded for the first time in India from Namdapha National Park. Hence, the present record makes the westernmost dis

Background: Functional abdominal pain disorders (FAPDs) affect children, especially girls, all over the world. The evidence for existing treatments is mixed, and effective accessible treatments are needed. Dance, a rhythmic cardio-respiratory activity, combined with yoga, which enhances relaxation and focus, may provide physiological and psychological benefits that could help to ease pain. Objecti

Background and purpose — Strenuous efforts to minimize postoperative infection rates have been made, including the Swedish nationwide initiative Prosthesis Related Infections Shall be Stopped (PRISS). This study calculated the incidence rate of periprosthetic joint infection (PJI) following primary total knee arthroplasty (TKA) before and after PRISS. Patients and methods — All 45,438 primary TKAs

Why did France experience the demographic transition first? This question remains one of the greatest puzzles of economics, demography, and economic history. The French pattern is hard to reconcile with elucidations of the process as found in other countries. The present analysis goes back to the roots of the process and offers novel ways of explaining why people started to control their fertility

Studies have shown a need to consider environmental factors to best support the rehabilitation and recovery process after a stroke. In addition, despite intentions to increase individuals’ participation in care and rehabilitation, patients and family members report weak participation. The aim of this study was to explore how the environment was integrated into rehabilitation at home from the persp

In biomass thermal conversion processes, the release of potassium in high temperature environments crucially influences the operating efficiency and safety. The dominant potassium species can be potassium hydroxide (KOH) and/or potassium chloride (KCl). We report a species-specified quantitative measurement of potassium hydroxide (KOH) in combustion environments using laser-induced photofragmentat

Dendritic cells (DCs) with capacity of antigen cross-presentation are of key interest for immunotherapy against cancer as they can induce antigen-specific cytotoxic T lymphocyte (CTL) responses. This study describes frequencies of DC subtypes in human tonsils and lymph nodes, and phenotypic aspects that may be targeted by adjuvant measures. From human tonsils and neck lymph nodes, DCs were identif

This post presents a political and legal analysis of the emergency brake in criminal law in Articles 82(3) and 83(3) TFEU. It suggests that the emergency brake offers a powerful discretionary prerogative for Member States seeking to protect the integrity of their criminal justice systems. This strong legal shield for Member States in the form of a ‘quasi-veto’ is contrasted with a tendency to deci

Understanding the transport and deposition of the cosmogenic isotope 10Be is vital for the application of the isotope data to infer past changes of solar activity, to reconstruct past Earth’s magnetic field intensity and climate change. Here, we use data of the cosmogenic isotope 10Be from the Greenland ice cores, namely the NEEM and GRIP ice cores, to identify factors controlling its distribution

At stake in this forum are the politics of translation in the study of global politics. More specifically, the following interventions aim to consider the ways that scholars can recenter the utility of language toward more flexible conceptions of relationality. As each contribution reveals, translation is indispensable to individual theorizations of international politics; yet taken together, the

Adipocyte-rich omentum offers “good soil” for disseminating ovarian cancer (OvCa), contributing to therapeutic difficulty. However, little is understood about the association between adipocytes and tumor growth at peritoneal dissemination site. Herein, we report the induction of adipocyte dedifferentiation by OvCa cells and pro-tumorigenic effects of resulted adipocyte-derived fibroblasts. We conf