Central pathology evaluation in a novel hypo catabolic mouse model of HD; R6/2; Ob/Ob mice
Huntington’s disease is a hereditary neurodegenerative disease caused by an expansion of CAG repeats in the huntingtin (HTT) gene. HD is fully penetrant around 40 CAG repeats and is characterized by motor impairments, psychiatric disturbances and cognitive deterioration. Unintended weight loss is also a clinical feature of HD, leading to reduced morality and a decline in quality of life in HD pati