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Skeletal muscle has high energy requirement and alterations in metabolism are associated with pathological conditions causing muscle wasting and impaired regeneration. Congenital muscular dystrophy type 1A (MDC1A) is a severe muscle disorder caused by mutations in the LAMA2 gene. Leigh syndrome (LS) is a neurometabolic disease caused by mutations in genes related to mitochondrial function. Skeleta
The adrenal-derived hormones dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are the most abundant circulating hormones and their levels decline substantially with age. DHEAS is considered an inactive precursor, which is converted into androgens and estrogens via local metabolism in peripheral target tissues. The predictive value of serum DHEAS for fracture risk is unknown. The aim of this s
Automatic video captioning is challenging due to the complex interactions in dynamic real scenes. A comprehensive system would ultimately localize and track the objects, actions and interactions present in a video and generate a description that relies on temporal localization in order to ground the visual concepts. However, most existing automatic video captioning systems map from raw video data
We aimed to conduct a narrative review of the rapid advances in knowledge regarding sun exposure and all-cause mortality. Data support the hypothesis that sun exposure avoidance is a major risk factor for all-cause mortality in adjusted analysis (age, income, education, marital status, smoking, and comorbidity). This was caused by an increased risk of death due to cardiovascular disease (CVD) and
Photosensitive diurethanes were prepared from a green chemistry synthesis pathway based on methacrylate-functionalized six-membered cyclic carbonate and biogenic amines. A continuous optical 3D printing method for the diurethanes was developed to create user-defined gradient stiffness and smooth complex surface microstructures in seconds. The green chemistry-derived polyurethane (gPU) showed high
The Chandra Deep Field South (CDF-S) was observed by XMM-Newton for about 3Ms in many periods over the past decade (2001-2002 and 2008-2009). The main goal of the survey was to obtain good quality X-ray spectroscopy of the active galactic nuclei responsible for the bulk of the X-ray background. We present the scientific highlights of the XMM-Newton survey and briefly discuss the perspectives of fu
To explore the advantages of emerging all-polymer solar cells (all-PSCs), growing efforts have been devoted to developing matched donor and acceptor polymers to outperform fullerene-based PSCs. In this work, a detailed characterization and comparison of all-PSCs using a set of donor and acceptor polymers with both conventional and inverted device structures is performed. A simple method to quantif
Previous research has shown considerable marriage premiums in earnings for men, but often penalties for women of being in a union. In this study we extend this research by analyzing how the age difference between spouses affects the earnings profiles by gender. As we follow people over time in advance as well as within their marriage, we can separate premarital from postmarital earnings movements.
We study the social mobility of women by looking at the connection between migration and marriage outcomes using complete count census data for Sweden. The censuses 1880-1900 have been linked at the individual level, enabling us to follow 100,000 women from their parental home to their new marital household. Marriage market imbalances were not an important push factor for migration but we find a s
Dosimetric errors in a magnetic resonance imaging (MRI) only radiotherapy workflow may be caused by system specific geometric distortion from MRI. The aim of this study was to evaluate the impact on planned dose distribution and delineated structures for prostate patients, originating from this distortion. A method was developed, in which computer tomography (CT) images were distorted using the MR
Whenever a material object is selected to represent a physically absent, but emotionally present referent, such as a religious figure or a deceased relative, we have a complex representation situation that involves what we could tentatively label “transgressive cognitive acts”. A transgressive cognitive act is here meant to involve a part that is experienced as present, and as having an effect, bu
Global warming can substantially affect the export of dissolved organic carbon (DOC) from peat-permafrost to aquatic systems. The direct degradability of such peat-derived DOC, however, is poorly constrained because previous permafrost thaw studies have mainly addressed mineral soil catchments or DOC pools that have already been processed in surface waters. We incubated peat cores from a palsa mir
AbstractThis presentation is based on my article (Un)becoming Dysfunctional: ADHD and How Matter Comes to Matter (2016). The main theme of the article is to problematize the biomedical model of the so-called neuropsychiatric disorder Attention Deficit Hyperactivity Disorder (ADHD). Various neuropsychiatric disorders are a common feature today, not least in educational contexts where ADHD is a comm
Globalization has resulted in more segments and product configurations to meet the needs of various customers in different markets. For manufacturers to keep up, the operations footprint has become more global to source fromthe most appropriate suppliers but also have manufacturing sites in close proximity to the main local markets. The relationship between the products offered, in particular the Globalization has resulted in more segments and product configurations to meet the needs of various customers in different markets. For manufacturers to keep up, the operations footprint has become more global to source from the most appropriate suppliers but also have manufacturing sites in close proximity to the main local markets. The relationship between the products offered, in particular the
Bradykinin B1 receptors (B1R) are rapidly induced after tissue trauma and are thought to be involved in maintaining the inflammatory response. Little is known about the intracellular signaling pathways mediating B1R induction in response to stress and inflammation. Here, we show that up-regulation of B1R by B1R agonist and interleukin-1β (IL-1β) occur through distinct but synergistic pathways in I
In this study, we analysed the agonist-promoted trafficking of human B2 (B2R) and B1(B1R) bradykinin (BK) receptors using wild-type and green fluorescent protein (GFP)-tagged receptors in HEK293 cells. B2R was sequestered to a major extent upon exposure to BK, as determined by the loss of cell-surface B2R using radioligand binding and by imaging of B2R-GFP using laser-scanning confocal fluorescenc
The B1 bradykinin (BK) receptor (B1R) is a seven-transmembrane domain, G protein-coupled receptor that is induced by injury and important in inflammation and nociception. Here, we show that the human B1R exhibits a high level of ligand-independent, constitutive activity. Constitutive activity was identified by the increase in basal cellular phosphoinositide hydrolysis as a function of the density
