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Decision and Value of Information analyses can be highly computational demanding due to the exponential growth of the decision tree in dependency of the state and decision variables. Due to the advancement of computational methods in the last decades, decision problems with moderate complexity maybe solved by a software tool whereas highly complex analyses require tailored approaches, algorithms a
Mandatory vaccination interferes with personal integrity but may be necessary to safeguard public health. However, states must consider all relevant factors in context and ensure such policies do not place disproportionate burdens on those hesitant about vaccination.
Social entrepreneurship is often depicted as the solution to the various problems we have in society today. In the mainstream literature, it tends to be presented as a site of empowerment, inclusion, morality and compassion. However, while much attention has been granted the ‘entrepreneurship’ part of the term, we know less about the ‘social’ in social entrepreneurship. The meaning of the ‘social’
The essay follows the theoretical framework of the fantastic as settled by TzvetanTodorov and aims at identifying the place of the Romanian novella within this classification. For the fantastic as strangeness the essay identifies within the novella: the hesitation of the reader between the reality and the imaginary, the events as a result of one’s imagination due to madness or to dream; the hesita
Spectral analysis encompasses several powerful signal processing methods. The papers in this thesis present methods for finding good spectral representations, and methods both for stationary and non-stationary signals are considered. Stationary methods can be used for real-time evaluation, analysing shorter segments of an incoming signal, while non-stationary methods can be used to analyse the ins
Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP and POLG, have been linked to these rare diseases. The human genome encodes three DNA ligases, of which only one, ligase III (LIG3), has a mitochondrial splice variant and is crucial for mitochondrial health. We investigated the effect of reduced LIG3 activity and resulting mitochon
Paediatric movement disorders (PMDs) comprise a large group of disorders (tics, myoclonus, tremor, dystonia, chorea, Parkinsonism, ataxia), often with mixed phenotypes. Determination of the underlying aetiology can be difficult given the broad differential diagnosis and the complexity of the genotype–phenotype relationships. This can make the diagnostic process time-consuming and difficult. In thi
Viral etiology of nasal polyps was postulated as many as 40 years ago, but so far, no study has shown an association or causal relation between any specific virus and nasal polyps. By using the polymerase chain reaction (PCR) technique, nasal polyps from both 10 patients with intolerance to nonsteroidal anti-inflammatory drugs (NSAID intolerance) (e.g., Aspirin) and from 10 patients with no histor
Proteogenomic approaches have enabled the generat̲ion of novel information levels when compared to single omics studies although burdened by extensive experimental efforts. Here, we improved a data-independent acquisition mass spectrometry proteogenomic workflow to reveal distinct molecular features related to mammographic appearances in breast cancer. Our results reveal splicing processes detecta
The nasal mucosa harbors sensory nerves containing neuropeptides such as substance P (SP), which are released by capsaicin. The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa. We studied the effect of enzymatically active recombinant NEP (rNEP) on neuropeptide-evoked secretion of nasal fluid and plasma exudation in rats. rNEP adminis
