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The field of extracellular vesicles (EVs) is rapidly advancing, offering promising applications in diagnostics, therapeutics, and drug delivery. However, the translation of EV-based technologies to the clinic faces significant challenges related to heterogeneity, scalable biomanufacturing, and regulatory compliance. To address these issues, the European Innovation Council (EIC), in collaboration w

Epigenetic drift, which is gradual age-related changes in DNA methylation patterns, plays a significant role in aging and age-related diseases. However, the relationship between exercise, epigenetics, and aging, and the molecular mechanisms underlying their interactions are poorly understood. Here, we investigated the relationship between cardiorespiratory fitness (CRF), epigenetic aging, and prom

Background: This study compared levels of physical activity (PA) and sedentary behavior (SB) in adults with and without chronic diseases or multimorbidity, acknowledging sociodemographic factors. Methods: A cross-sectional analysis was conducted with data from 27,890 participants (52% women), aged 50–64, from the Swedish CArdioPulmonary bioImage Study cohort. Over 1500 chronic diseases were includ

LIDAR techniques have been extensively used for studies of aerosol particles. Fluorescence LIDAR was employed for studying natural bio aerosols, such as pollen, but also possible warfare agents. Insects, being "large aerosol" particles clearly give rise to LIDAR returns. Recently, honey bees were studied by polarization reflectance LIDAR and their superior olfactory abilities were used in attempts

As a crucial tool for enhancing the readability and comprehensibility of geoinformation, automated label placement in mapping applications remains a significant challenge, particularly when generalizing the label placement process for high-density maps, despite the availability of tools such as QGIS-PAL and ArcGIS-Maplex label engine. This study focuses on utilizing deep learning (DL) for road lab

Gamma-ray observations of the astrophysical neutrino sources are fundamentally important for understanding the underlying neutrino production mechanism. We investigate the Cherenkov Telescope Array (CTA) ability to detect the very-high-energy (VHE) gamma-ray counterparts to the neutrino-emitting Active Galaxies. The CTA performance under different configurations and array layouts is computed based

We present the development of a new colour reconnection model in Pythia where the full spacetime separation between partons constrains the reconnection probability throughout the final-state radiative shower. Building upon previous ideas of a perturbative dipole-based model, our objective is to introduce realistic spatially-based colour reconnections within the Angantyr model for heavy-ion collisi

We have adapted an optical transmission microscope to multispectral imaging in order to diagnose Plasmodium falciparum without using fluorescent labels for parasites as is the case for the thick and thin blood smears. We show how a set of monochromatic Light Emitting Diodes (LEDs) has provided an efficient contrast and spatial resolution to identify the parasites inside the erythrocytes. The obtai

Despite the advancement in background rejection techniques, observation of the very-high-energy gamma-ray sky by imaging atmospheric Cherenkov telescopes (IACTs) are subject to an irreducible background from gamma-like hadron- or electron-induced air showers. The determination of this residual background is crucial for accurate spectral and spatial measurements. The Cherenkov Telescope Array (CTA)

BACKGROUND: Seizure duration during electroconvulsive therapy (ECT) correlates with treatment efficacy and may be influenced by depth of anaesthesia. The Patient State Index (PSi), derived from processed EEG, offers a potential method to monitor depth of anaesthesia during ECT. This study examined the correlation between pre-ictal PSi and EEG-seizure duration.METHODS: In this prospective observati

Background/Objectives: Older patients are more susceptible to the process of understanding and retrieving information. To provide adequate preoperative information, reduce their vulnerability and anxiety, and thereby facilitate pre-, intra-, and postoperative care, the adoption of new information technologies is essential. This study aimed to explore elderly patients' experiences and perceptions o

Cross-system fluxes of aquatic insects rich in omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs), specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may subsidise insectivorous vertebrates that are suffering due to terrestrial insect declines. The benefits of high ω-3 LC-PUFA diets, such as improved growth and immunocompetence, have previously been demonstrated fo

We present a new suite of edge ('Engineering Dwarfs at Galaxy formation's Edge') cosmological zoom simulations. The suite includes 15 radiation-hydrodynamical dwarf galaxies covering the ultrafaint to the dwarf irregular regime () to enable comparisons with observed scaling relations. Each object in the suite is evolved at high resolution () and includes stellar radiation, winds, and supernova fee

Atmospheric measurements of the short-lived radioactive noble gas radon-222 (222Rn) have many applications. Its concentrations are driven by atmospheric mixing as well as seasonal variations, which follow the seasonality of 222Rn exhalation from continental soils, with lower values during the wet winter and spring months compared to more dry summer conditions. Hence, it can be used as a tracer to

This paper reviews the recent advancements in inverter topologies and control techniques for grid-connected photovoltaic systems. As photovoltaic penetration continues to increase, modern power systems need high performance inverters which can maintain reliability, power quality and compliance with evolving grid codes. Although these inverters are advancing over the years, there is no existing rev

Here, we use carbon dioxide (CO2), methane (CH4), carbon monoxide (CO), nitrous oxide (N2O) and radon (222Rn) data from the Saclay ICOS tall tower in France to estimate CO2, CH4 and CO fluxes within the station footprint from January 2017 to October 2024 and N2O fluxes from February 2019 to October 2024 using the Radon Tracer Method (RTM). We first performed a sensitivity study of this method appl