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Background and aims: Histopathology is the gold standard for analysis of atherosclerotic plaques but has drawbacks due to the destructive nature of the method. Ex vivo MRI is a non-destructive method to image whole plaques. Our aim was to use quantitative high field ex vivo MRI to classify plaque components, with histology as gold standard.Methods: Surgically resected carotid plaques from 12 patie
Management of asymptomatic carotid disease continues to challenge medical practice and present evidence is often conflicting. Stroke is a significant burden in Public Health and 11% to 15% appear as first neurologic event associated with asymptomatic carotid stenosis. Randomized trials provided support for Guidelines and Recommendations to intervene on asymptomatic stenosis, but at a known cost of
Den första av två artiklar rörande det fängelse, den s k proban, som Lunds universitet hade under den tid lärosätet ägde egen jurisdiktion över anställda och studenter. Denna första del behandlar fenomenet med skol- och universitetsfängelser generellt samt Lunds universitets specifika sådana under 1600- och 1700-talen.
Subarctic forest-tundra ecotones dominated by mountain birch (Betula pubescens ssp. czerepanovii) are an important habitat for semi-domestic reindeer Rangifer tarandus. The seasonal timing of reindeer grazing may direct vegetation trajectories in these systems, because in the summer ranges, mountain birches are subjected to browsing, while in the winter ranges, reindeer feed on understorey vegetat
Med denna svenska översikt av våra egna och andra forskares observationer av mörka neuron vid mikrovågs exponering från mobiltelefoner, som lite senkommet tillägnas Arne Brun på hans 90 års-dag, vill vi att hans insatser blir uppmärksammade och inte faller i glömska.Kring 2000 millennium skiftet pågick ett intensivt arbete i Lund med att sammanfatta och bekräfta effekterna av exponering med GSM-90
This chapter draws on Lefebvre’s Rhythmanalysis and Production of Space as conceptual, political and metaphorical reservoirs to examine the way in which international protection provisions, as enshrined in international human rights law, are challenged and undermined by current EU migration policies of migration deterrence and containment. In the context of socio-spatial practice, Rhythmanalysis f
This thesis investigates ‘the doing’ of the Swedish social insurance program Activity Compensation (AC). AC is an example of disability policies in Western welfare states. These policies have two goals: to ensure financial security and to promote social participation. In 2003 AC replaced Early Retirement Pension for persons aged 19 to 29 years and who, for medical reasons, have reduced work capaci
Background: Around the globe the electricity sector is strikingly similar, as regardless of nation it is structured around centralized large-scale power production. However, these centralized systems are currently experiencing operational problems related to climate change, energy security and aging grid infrastructures. In Sweden, the lack of investment and maintenance of the grid have created bo
In the context of the COVID-19 pandemic, governments worldwide face the challenge of designing tailored measures of epidemic control to provide reliable health protection while allowing societal and economic activity. In this paper, we propose an extension of the epidemiological SEIR model to enable a detailed analysis of commonly discussed tailored measures of epidemic control—among them group-sp
Control of contemporary, multi-joint prosthetic hands is commonly realized by using electromyographic signals from the muscles remaining after amputation at the forearm level. Although this principle is trying to imitate the natural control structure where muscles control the joints of the hand, in practice, myoelectric control provides only basic hand functions to an amputee using a dexterous pro
Background: The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and have been associated with various clinical properties including tamoxifen resistance. Recent data further suggest that progranul
Andelen unga som beviljas förtidspension under lång tid har ökat, särskilt de med en psykisk diagnos eller unga med lindrig psykisk ohälsa. Denna form av utanförskap innebär att betydande andelar av en generation av unga människor har liten eller ingen koppling till arbetsmarknaden under en större del av sitt vuxna liv.Bara i Sverige har antalet förtidspensionerade mellan 19-29 år fördubblats unde
An increase in dopamine (DA) synthesis capacity in the dorsal striatum (DS) during the prodromal stage of schizophrenia becomes more pronounced as patients progress to the full disorder. Understanding this progression is critical to intervening in disease course. We developed an animal model—Enhanced Dopamine in Prodromal Schizophrenia (EDiPS)—which uses a genetic construct to increase DA synthesi
Presentation of the Filmform Foundation and its archive of experimental film and video, at the website filmarkivet.se, directed by Swedish Film Institute.
Adjuvant systemic therapies are now routinely used following resection of stage III melanoma, however accurate prognostic information is needed to better stratify patients. We use differential expression analyses of primary tumours from 204 RNA-sequenced melanomas within a large adjuvant trial, identifying a 121 metastasis-associated gene signature. This signature strongly associated with progress
Most of the drugs currently prescribed for cancer treatment are riddled with substantial side effects. In order to develop more effective and specific strategies to treat cancer, it is of importance to understand the biology of drug targets, particularly the newly emerging ones. A comprehensive evaluation of these targets will benefit drug development with increased likelihood for success in clini
