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Development of a defined minimal culture medium for Prevotella copri DSM 18205
The human gut microbiota is involved in the host’s health and disease. There has been growing interest in the next generation probiotic candidate Prevotella copri, which plays a beneficial role in glucose metabolism. It is a Gram-negative obligate anaerobe that was first isolated from human faeces and which is present in plant-based fermented foods as well as in human breast milk. The aim of this
Synthetic Route towards macrocyclic Galectin-3 Inhibitors
Galectins are a 15-member family of β-D-galactose binding proteins that are interesting targets in drug development, since they are linked to various inflammatory diseases, fibrosis and cancer. Efforts to find galactose derived high-affinity inhibitors that are selective towards members of the galectin-family have increased in the last decade. On top of that Galectin-3 has been shown to be a suita
Electrical wiring of Shewanella oneidensis MR-1 with osmium polymers of different redox potentials
The results of studies have shown that the several applications such as microbial electrochemical system (MES), bio-electrochemical systems (BESs) and production of beneficial chemicals are due to electrochemical connection among electrodes and microorganisms. The following two factors are important in choosing the microbe mediated electrochemical biosensors: I) Binding of bacterial cells on the e
Distribution Modelling of Gene Drive-Modified Mosquitoes and Their Effects on Wild Populations
Emerging technologies have the potential to bring numerous new opportunities and solutions to the existing challenges, including addressing sustainable development goals (SDGs). Particular hopes are given to areas of the life that require our urgent action, these include but are not limited to medicine and food security. Scientists investigate how these technological advances can be applied for th
Gårdagens framtid, dagens standard.
Visualisation of network loading and the impact of solar power at secondary substations in Lund.
Electrical power distribution is currently seeing both challenges and opportunities. On one hand, the digitisation of measurement data and modern measurement devices enable deeper analysis and planning of the grid. On the other hand, the expansion of privately owned photovoltaic systems and the customers' desire to produce their own electricity is an inevitable challenge that distribution comp
Ground validation and bias correction of GPM-IMERG V6 satellite precipitation product over Sweden
This study attempts to assess and correct the performance of Integrated Multi-satellite Retrievals for Global Precipitation Measurement (GPM-IMERG) final run daily precipitation product across Sweden. The performance of GPM-IMERG version 6 final run was evaluated against 677 rain gauges in a period from 12 March 2014 to 31 May 2019. Continuous and categorical performance measures were used to char
CUSTOMIZED QUANTIFICATION OF HOST CELL PROTEIN WITH BIO-LAYER INTERFEROMETRY
Visste du att många läkemedel tillverkas av genmodifierade bakterier? Också ofta i genmodifierade celler från däggdjur, till exempel från kinesiska hamstrars äggstockar. Läkemedel producerade i celler är de snabbast växande på marknaden, och kan till exempel användas för att producera insulin eller ett COVID-19 vaccin. I denna studie har en ny metod utvecklats för att säkerställa att sådana läkemeHost cell protein (HCP) is quantified in the purification steps of biopharmaceutical production and is part of ensuring the purity of the final drug product. The gold standard method for HCP quantification is enzyme-linked immunosorbent assay (ELISA), but a new approach is proposed here with fully customized bio-layer interferometry assays for yeast and chinese hamster ovary (CHO) cells. The new
Topology optimization with optimal spatially varying length scale
Density based topology optimization has become an efficient way to design optimal complex structures with different goals, constraints and boundary conditions. To regularize the solution, density filters are utilized and is controlled by the length scale. The length scale controls minimum feature sizes, as well as minimum curvatures in the structure. Usually a constant length scale is used through
Reaching for the Stars: An exploratory study to conceptualize product iconicity
Background/Problematization: Iconic brands are the gold standard of branding and have established a central role in the consumers’ lives. Behind every iconic brand, we can find iconic products. Despite the importance of these products, iconic products are overlooked in academia. Few studies have explored the concept and there is no common definition or comprehensive framework. This is restrictive
Charterturism 2.0 - vem vill inte åka på en paketresa, eller?
Stars Eating Planets
In a phase of instability during the dynamical evolution of some multiple exoplanetary systems, exchange of angular momentum and/or energy through gravitational interactions between planets will lead to alterations of their orbital properties. In some cases, planetary orbits end up crossing, which leads to close encounters between two planets. In turn, they undergo a planet--planet scattering even
Link performance measurement and improvement using Bluetooth mesh network
Bluetooth is a short-range technology, it helps with wireless communication between many electronic devices. Bluetooth low energy (BLE) is the advanced version of Bluetooth which uses low energy compared to the standard Bluetooth. Bluetooth mesh technology play a crucial role in the Internet of things (IoT). The IoT mesh technology enables many-to-many and one-to-many communication. This project d
Identification of high-amylose lines in a mutagenized oat population
Oat starch, like starch from other plants, is composed of amylose and amylopectin. The arrangement and abundance of these polysaccharides offers distinct properties to the formed starch. Starch with an elevated amount of amylose is of commercial interest and amount of amylose present in oats differs within cultivars. In this study, a mutant oat population developed by CropTailor was screened usin
Det dubbla främlingskapet - Invandrarens dilemma: att leva med eller mellan två kulturer
The study considers the phenomenon of double alienation, by which is meant the immigrant’s feeling of in a sense being alienated in their native country as well as in the new one. Those elements of their behaviour which are common in the one country or the other are expected there, whereas those which are not are seen as strange and different. This gives the immigrant a feeling of being at home in
LOKALISERA - alternativa framtider sprungna ur lokala förutsättningar
Vi lever idag i en värld vars system och strukturer tillåter oss människor att konsumera och producera långt över våra tillgångar. Om inga åtgärder görs riskerar vi oåterkalleliga förändringar i klimat och miljö som kommer att påverka förutsättningarna för kommande generationer. Klimatkrisen är global men vi måste agera lokalt. Nu. Hur vi utformar byggnader och samhällen har stor inverkan på milj
The Over-research & NGOisation Paradigm of the West Bank: Applied Cultural Analysis on the 'futility of research' and the 'burden of occupation'
The West Bank attracts countless researchers due to the conflict’s intractable label. On one hand, these researchers are drawn to the Palestinian-Israeli conflict due to logistical reasons: accessibility to the area, academic prestige, ample funding, grant and networking opportunities. On the other, researchers are allured due to an Orientalist fascination with conducting fieldwork in the West Ban
Reuse of white goods components - An interview study on drivers, barriers, and the future outlook
Utarmningen av resurser är ett växande problem som har påskyndat behovet att förändra våra konsumtionsmönster. Gamla, linjära modeller för produktion måste ersättas av nya tillvägagångssätt som minskar mängden avfall och maximerar värdet genom hela produktens livscykel. Denna strategi förkroppsligas av den Cirkulära Ekonomin (CE). En viktig del av CE är återbruk, det vill säga att gamla produkter The growing threat of resource depletion has spurred on the need to change how we consume. Old, linear modes of production must be replaced by an approach that reduces waste and maximizes value throughout the product’s entire life cycle. This strategy is embodied by the Circular Economy (CE). A key aspect of CE is reuse, referring to the repurposing of old products to avoid generating waste and de
Att leda i kris - En fenomenologisk studie om krisledarskap i organisationer
Världen och samhället på alla nivåer har i samband med Covid-19 ställts inför en kris. I organisationer bär ledarna i samband med en kris ansvaret för krishantering. Denna uppsats analyserar ledares upplevelse av att leda i kris inom organisationer samt ger förslag för hur krisledarskap kan förbättras. Uppsatsen har en kvalitativ ansats och den deskriptiva fenomenologiska metoden ligger till grun