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Obesity induces molecular changes that may favor tumor progression and metastatic spread, leading to impaired survival outcomes in breast cancer. Adenylate cyclase-associated protein 1 (CAP1), an actin regulatory protein and functional receptor for the obesity-associated adipokine resistin, has been implicated with inferior cancer prognosis. Here, the objective was to investigate the interplay bet

https://www.lupop.lu.se/article/effects-tumor-specific-cap1-expression-and-body-constitution-clinical-outcomes-patients-early-breast - 2025-10-03

Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe critically ill patients with severe sepsis or septic shock due to invasive GAS (iGAS) and compare them with other patients with severe sepsis or septic shock. Read more at https://ccforum.biomedcentra

https://www.lupop.lu.se/article/morbidity-and-mortality-critically-ill-patients-invasive-group-streptococcus-infection-observational - 2025-10-03

Pre-hospital circumstances, cardiac arrest characteristics, comorbidities and clinical status on admission are strongly associated with outcome after out-of-hospital cardiac arrest (OHCA). Early prediction of outcome may inform prognosis, tailor therapy and help in interpreting the intervention effect in heterogenous clinical trials. This study aimed to create a model for early prediction of outco

https://www.lupop.lu.se/article/artificial-neural-networks-improve-early-outcome-prediction-and-risk-classification-out-hospital - 2025-10-03

The etiology of type-2 diabetes is only partly known, and a possible role of prenatal stress in programming offspring for insulin resistance has been suggested by animal models. Previously, we found an association between prenatal stress and type-1 diabetes. Here we examine the association between prenatal exposure to maternal bereavement during preconception and pregnancy and development of type-

https://www.lupop.lu.se/article/prenatal-exposure-bereavement-and-type-2-diabetes-danish-longitudinal-population-based-study - 2025-10-03

Problem gambling is a public health issue and its comorbidity with other health conditions may provide an opportunity for screening in healthcare settings; however, a high level of uncertainty and a lack of research in the field remains. The objective of this study is to investigate potential associations between problem gambling and numerous other health conditions, including substance use, menta

https://www.lupop.lu.se/article/problem-gambling-associations-comorbid-health-conditions-substance-use-and-behavioural-addictions - 2025-10-03

Results from a cohort study from Lund University suggest that laughter actually is the best medicine (in Swedish) Att ett gott skratt förlänger livet är ett välanvänt ordspråk – men faktum är att det stämmer. I alla fall enligt en ny studie från Lunds universitet. – Vi ser helt enkelt ett samband, säger Gunnar Engström, professor i medicinsk epidemiolog, till TT.Läs mer här.

https://www.lupop.lu.se/article/laughter-best-medicine - 2025-10-03

Even though abdominal aortic aneurysm (AAA) and coronary heart disease (CHD) are both related to atherosclerosis, there could be important differences in risk factors. Based on Malmö Diet and Cancer Cohort, the incidence of AAA and CHD was followed prospectively. Cox regression was used to calculate the association of each factor with AAA and CHD and hazards ratio were compared using a modified Lu

https://www.lupop.lu.se/article/comparisons-risk-factors-abdominal-aortic-aneurysm-and-coronary-heart-disease-prospective-cohort - 2025-10-03

A compulsory swimming education programme was launched in 2014 in second grade (at age 8) in all public primary schools in Malmö, Sweden. Data for the present study on sociodemographic conditions and self-reported swimming ability in fourth grade (age 10) were used for the last birth cohort unexposed (n = 1695) and the first birth cohort exposed (n = 1773) to the intervention. Read more at https:/

https://www.lupop.lu.se/article/socioeconomic-differences-swimming-ability-among-children-malmo-southern-sweden-initial-results - 2025-10-03

Parental role strain was related to young parental age at first birth, female gender, non-married status, age of youngest child, age range of children, number of children in the household, and the parent’s own chronic illness. Furthermore, chronic illness or disability of a child was markedly related to higher parental role strain, although the relationship was partly reduced with parental employm

https://www.lupop.lu.se/article/sociodemographic-and-health-status-predictors-parental-role-strain-general-population-study - 2025-10-03

Self-efficacy refers to a person´s confidence in carrying out treatment-related activities and constitutes the foundation of self-management as well as long-term follow-up after heart transplantation. Exploring the heart recipients´ experiences by means of self-report instruments provides healthcare professionals with valuable information on how to supply self-management support after heart transp

https://www.lupop.lu.se/article/self-efficacy-recovery-and-psychological-wellbeing-one-five-years-after-heart-transplantation - 2025-10-03

Cellular rejection is most common 3–6 months after heart transplantation while chronic rejection, that is, cardiac allograft vasculopathy and malignancy are the most common causes of death in heart-transplant recipients beyond the third year after transplantation. However, the heart transplantation recipient’s perceived threat of graft rejection has never been explored. Read more at https://journa

https://www.lupop.lu.se/article/fear-graft-rejection-after-heart-transplantation-nationwide-cross-sectional-cohort-study - 2025-10-03

For this prospective observational study, data on demographics, functional status and living conditions were obtained from the Swedish Stroke Register (Riksstroke). Data on comorbidity and hospital readmissions up to five years post-index stroke were obtained from the Swedish National Patient Register. Patients were grouped based on number of readmissions: low (0–1) intermediate (2–4), high (5–9)

https://www.lupop.lu.se/article/patterns-hospital-readmissions-after-ischaemic-stroke-observational-study-swedish-stroke-register - 2025-10-03

Lost workdays following rotator cuff repair is not well-studied in the literature. We aimed to define the time away from work following early arthroscopic repair of acute traumatic rotator cuff tears and compare it with the recommendations of the American Medical Disability Advisor (MD Guidelines) and The Swedish Social Insurance Agency. Read more at https://link.springer.com/article/10.1007/s0006

https://www.lupop.lu.se/article/return-work-after-early-repair-acute-traumatic-rotator-cuff-tears - 2025-10-03

The prevalence of hip and groin problems in professional male ice hockey is unknown and suspected to differ between playing positions. The purpose of this study was to explore potential differences in the seasonal prevalence of hip and groin problems between playing positions in male elite ice hockey players and to explore the relationship between symptom duration and hip and groin function at the

https://www.lupop.lu.se/article/high-prevalence-hip-and-groin-problems-professional-ice-hockey-players-regardless-playing-position - 2025-10-03

The abnormal deposition of tau begins before the onset of clinical symptoms and seems to target specific brain networks. The aim of this study is to identify the spatial patterns of tau deposition in cognitively normal older adults and assess whether they are related to amyloid-β (Aβ), APOE, sex, and longitudinal cognitive decline. Read more at https://link.springer.com/article/10.1007/s00259-019-

https://www.lupop.lu.se/article/spatial-patterns-tau-deposition-are-associated-amyloid-apoe-sex-and-cognitive-decline-older-adults - 2025-10-03

In this prospective cohort study, Malmö Diet and Cancer Study, baseline data collection was carried out 1991–1996. The study participants’ (n = 26,133) dietary habits were extensively recorded at baseline. The specific diagnosis of AAA in the in-hospital registry was found valid in 95%. The association between plant foods, such as cereals and types of vegetables, and AAA was assessed by using Cox

https://www.lupop.lu.se/article/intake-fibre-and-plant-foods-and-risk-abdominal-aortic-aneurysm-large-prospective-cohort-study - 2025-10-03

Adult health is influenced by factors during fetal life affecting organ development and birth weight. We aimed to study such factors in relation to adult respiratory disease (ARD) risk. The Helsingborg Birth Cohort, Sweden, contributed baseline data collected by medical staff through clinical examination and questionnaires on maternal and birth characteristics 1964–1967. Register linkages were per

https://www.lupop.lu.se/article/early-life-exposures-and-risk-adult-respiratory-disease-during-50-years-follow - 2025-10-03

There is some evidence that housing accessibility, external housing-related control beliefs (HCB) and activities of daily living (ADL) are associated in complex ways; however, these pathways have not been explored in younger old. The aim was to assess the role of external HCB in the relationship between housing accessibility and ADL by applying moderation and mediation models. This was a cross-sec

https://www.lupop.lu.se/article/associations-among-housing-accessibility-housing-related-control-beliefs-and-independence-activities - 2025-10-03

This study closely examines long-term outcomes of intermarriage in Denmark in terms of children’s educational performance, studying grades from final examinations. The study uses rich register data, where families are linked across generations, and contributes to the migration literature by providing new insights into the human capital formation in inter-ethnic families. The outcomes of children o

https://www.lupop.lu.se/article/intergenerational-effects-intermarriage - 2025-10-03

262 patients with SLE were included in the study; of these 175 were from the defined population. Overall, 37 AMI and 44 CVE were recorded. An increased IRR of 3 for AMI was found (p<0.001). Smoking, hypertension and reduced renal function were risk factors for AMI. An increased IRR of 3.3 for ischaemic CVE was found for women (p<0.001). Hypertension and aCL were risk factors for CVE. Organ damage

https://www.lupop.lu.se/article/disease-duration-age-diagnosis-and-organ-damage-are-important-factors-cardiovascular-disease-sle-0 - 2025-10-03