Hur kan antibiotikabehandling vid tuberkulos bidra till lungskada? Varför drabbas många tuberkulospatienter av långvariga lungskador, trots att infektionen är botad? Ny forskning visar att antibiotikan i sig kan spela en oväntad roll. När bakterierna utsätts för stressen som antibiotikan orsakar, börjar de släppa ifrån sig små kapslar, liknande mikroskopiska paket, som kan trigga immunförsvaret oTuberculosis (TB) affects millions of people annually and remains one of the leading causes of infectious diseases-related deaths in the world. Current anti-TB treatment consists of a prolonged regimen of multiple antibiotics, which effectively eliminates the bacteria when it is not antibiotic resistant. However, large proportions of the TB-treated individuals experience persistent pulmonary dysfu

Orala streptokocker – munhålans gynnare och eventuella fiende Streptokocker är associerade med flera infektionssjukdomar i olika delar av kroppen. En grupp streptokocker (orala streptokocker) återfinns främst i människans munhåla i både friska och sjuka individer. Tidigare studier har visat att orala streptokocker etableras i munhålan redan när vi är barn och finns kvar under hela livet. I den frOral streptococci colonize the oral cavity already during early childhood and establish the foundation for colonization by a multispecies oral microbiota. In the oral cavity, Streptococcus spp. contribute to both health and disease, and can also spread to the blood stream causing bacteremia and systemic diseases such as infectious endocarditis (IE) in certain risk groups. Molecular changes in oral

BACKGROUND: Aortic pulse wave velocity (PWV) is an indicator of vascular aging and has proven to be effective in adult cardiovascular risk assessment. To use it in young people to identify those who may be at increased cardiovascular disease risk, reference values need to be determined. The Youth Vascular Consortium is a large, international database which was established to investigate vascular a

Since the conceptualization of early vascular aging (EVA) in 2008, significant efforts have been made to develop and improve its assessment. Initially lead by the investigation of arterial stiffness through pulse wave velocity (PWV), several additional vascular aging biomarkers have gained prominence in recent years. Despite expanding literature addressing methodological concerns associated with t

With an ongoing housing shortage in Swedish cities, challenges such as limited land availability, financing, and the environmental impacts associated with new development prompt us to explore alternative solutions. As architecture is inevitably a form of aesthetics and the idea of transforming and re-adapting our existing structures to deal with these challenges gains traction in the architectur

In the background of intensifying global climate change and rapid urbanisation, the frequent occurrence of extreme hydrological events and the increase in surface pollution pose serious challenges to the environmental quality of water bodies. Moreover, with the significant increase in public awareness of environmental protection, higher demands have been placed on water quality monitoring techniqu

International collaboration has long been regarded as a beneficial endeavour in higher education, fostering shared scientific and educational advancements, as well as cultural understanding. However, in developed economies, such academic partnerships have increasingly become entangled with geopolitical dynamics, competitive interests and national security issues.

The ability to generate and control movement is essential for human interactions and overall well-being. Neuromuscular impairment caused by neurological injuries and diseases, such as stroke or limb amputation, severely limits the ability of affected individuals to interact with the surrounding environment, necessitating advanced strategies for rehabilitation and restoration of motor function. Vol

This work addresses the design of multi-agent coordination through high-order consensus protocols. While first-order consensus strategies are well-studied—with known robustness to uncertainties such as time delays, time-varying weights, and nonlinearities like saturations—the theoretical guarantees for high-order consensus are comparatively limited. We propose a compositional control framework tha

To carry out the search mission, an additional narrow-angle video camera is installed on board the unmanned aerial vehicle (UAV). This video camera can be re-aimed at objects detected in the image frame received from the main (navigation) video camera. The movement of the additional video camera is carried out by two coordinated electric drives using direct current motors or brushless direct curre

The study is devoted to the development of the 2DCAM hardware and software complex for the physical modeling of the two-coordinate positioning system of the additional video camera of the UAV using the Simulink environment. DYNAMIXEL actuator systems were used to create a complex prototype. They combine DC motor, reduction gearhead, controller, driver and network components.The AH-12A actuator is

In collaboration with Spanish and Portuguese musicians, the group has recorded a new album that was released in April 2023. With roots in Nordic folk music, Groupa plays music that reflects both a deep, long-standing connection to tradition and a strong, unyielding desire to constantly move forward. After an intense celebration of Groupa’s 40th anniversary in 2021, the group continues its work of

I denna rapport jämförs två olika grundläggningsmetoder med fokus på deras praktiska tillämpning och tillhörande klimatpåverkan i urbana miljöer. Syftet är att undersöka, belysa och öka kunskapen om mindre beprövade grundläggningsmetoder i Sverige, samt öka förståelsen för deras potentiella fördelar. Jämförelsen fokuserar på hur en permanent bärande sekantpålevägg utförd med CCFA-metoden kan vara This report presents a comparative analysis of two foundation methods, focusing on their practical implementation and environmental impact in urban environments. The aim is to examine and enhance understanding of less commonly used foundation techniques in Sweden, while also evaluating their potential advantages. The comparison specifically investigates whether a permanently load-bearing secant pi

Bayesian optimization is a widely used method for optimizing expensive black-box functions, with Expected Improvement being one of the most commonly used acquisition functions. In contrast, information-theoretic acquisition functions aim to reduce uncertainty about the function's optimum and are often considered fundamentally distinct from EI. In this work, we challenge this prevailing perspective

This thesis theoretically investigates electronic transport in different low dimensional nanostructures. The miniaturization of electronics means that we reach a limit where quantum effects play a role in electronic devices. To understand and improve electronics at this level it is important to understand the transport properties. Excellent control over the nanostructures also makes them a great p

A well-balanced exploration-exploitation trade-off is crucial for successful acquisition functions in Bayesian optimization. However, there is a lack of quantitative measures for exploration, making it difficult to analyze and compare different acquisition functions. This work introduces two novel approaches - observation traveling salesman distance and observation entropy - to quantify the explor

Nordic Raga is a project featuring three Swedish folk musicians—Mats Edén, Tina Quartey (replacing Dan Knagg), and Pär Moberg—who, together with Jyotsna Srikanth, explore what happens when Nordic folk music meets South Indian musical practice in arranging and improvising music. At this concert they played with:Maya Youssef (SYR/UK) – Arabic qanun, a trailblazer as a female qanun player.Jyotsna Sri

Introduction: Epidemiological studies on elite female ice hockey players are lacking but needed to tailor preventive efforts in this growing group of athletes. Therefore, the aim of this study was to describe the incidence, prevalence, and burden of health problems in elite female ice hockey players. Methods: In this prospective cohort study, we asked all Swedish Women's Hockey League (SWHL) playe

Recent work reported that simple Bayesian optimization methods perform well for high-dimensional real-world tasks, seemingly contradicting prior work and tribal knowledge. This paper investigates the 'why'. We identify fundamental challenges that arise in high-dimensional Bayesian optimization and explain why recent methods succeed. Our analysis shows that vanishing gradients caused by Gaussian pr