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The inherent diversity of approaches in proteomics research has led to a wide range of software solutions for data analysis. These software solutions encompass multiple tools, each employing different algorithms for various tasks such as peptide-spectrum matching, protein inference, quantification, statistical analysis, and visualization. To enable an unbiased comparison of commonly used bottom-up
This thesis aimed to increase the understanding of pump physiology in the remodeled heart compared to normal pump physiology.Study I was a cross-sectional observatory study investigating the regional contributions to stroke volume in patients with heart failure prior to cardiac resynchronization therapy (CRT) and tested the hypothesis that this characterization of pumping could predict CRT respons
Turbulent spray combustion in a generic kerosene-fueled single-cup combustor at typical idle and cruise conditions of an aeroengine are studied with Large Eddy Simulations (LES) using Lagrangian spray and finite-rate chemistry combustion modeling. Three reaction mechanisms of varying complexity are used to model the combustion chemistry. The choice of turbulence-chemistry interaction model is show
Objectives This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic antibody-associated vasculitis (AAV) registries. Methods Through creation of the vasculitis-specific Findable, Accessible, Interoperable, Reusable, VASCulitis ontology, we harmonised
Public discourse and political climate policymaking are based on scientific reports and propose technological solutions to solve the crisis, primarily by changing fossil fuels to renewable energy. Rather than questioning growth and the overuse of natural resources—which has been at the core of green concern for decades—green growth is the motor in an economy that aims for continuous economic spin,
Purpose of Review: Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical studies, a significant number of clinical trials using MSC-based treatment for COVID-19-associated ARDS were initiated during the global pandemic. Here, we aimed to discuss differences and similarities in clinical trials using MSC-based treatments for classi
BackgroundMale involvement in maternal health care has proven to be beneficial for improving maternal and child health and is often crucial in areas of family planning and contraceptive use. However, compared to male involvement in maternal health care, male involvement in contraceptive counselling is complex and controversial and thus faces certain challenges. Immigrant men in Sweden are often ac
Obesity is a complex and chronic disease affecting hundreds of millions of people worldwide and has reached epidemic proportions. It is important to understand the underlying mechanisms to tackle this devastating disease, thus preventing its comorbidities. The epigenome, including DNA methylation and histone modifications, appears to be the link between genetics and nongenetic factors, modulating
The bark beetle, Ips typographus (L.), is a major pest of Norway spruce, Picea abies (L.), causing enormous economic losses globally. The adult stage of the I. typographus has a complex life cycle (callow and sclerotized); the callow beetles feed ferociously, whereas sclerotized male beetles are more aggressive and pioneers in establishing new colonies. We conducted a comparative proteomics study
Breast cancer is now the most frequently diagnosed cancer in the world. Breast cancer prevention has gained increasing attention due to increasing breast cancer incidence rates in the West and can be actualized through lifestyle modifications or targeted interventions. Mammographic breast density (MBD) is a well-established independent breast cancer risk factor that is not well-understood on a mol
Research has supported the use of preperformance routines to successfully manage the period preceding sport performance. In contrast, little research has been done on the period succeeding skill execution. This article introduces a three-stage model for postperformance routines (PoPR) for novice motor learning and performance including emotion regulation, performance analysis and correction, and c
We demonstrate, using analytic models, simulations and experiments, that efficient generation of high-order harmonics is possible across a large range of parameters, if the density and medium length follow a hyperbolic equation.
This paper presents an injection-locked frequency tripler for 28-GHz direct-conversion transceivers, which takes a differential input and outputs a quadrature signal. A feedback system is added to ensure that lock occurs and to keep the quadrature error below 1° across operating frequencies and process corners. Simulations show that the tripler can cover the entire 24-30 GHz band across all corner
Flatness of the loss curve around a model at hand has been shown to empirically correlate with its generalization ability. Optimizing for flatness has been proposed as early as 1994 by Hochreiter and Schmidthuber, and was followed by more recent successful sharpness-aware optimization techniques. Their widespread adoption in practice, though, is dubious because of the lack of theoretically grounde
Introduction: The European corn borer (ECB), Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae), is a major pest insect in maize. New cultivars and climate change have allowed range expansion of the crop northwards in Europe, and a similar range expansion of associated pests has been predicted. ECB exists as two distinct pheromone strains using different blends of (E)-11-tetradecenyl acetate and
Fibromyalgia is a common chronic pain condition. Rates of contact allergy in individuals with fibromyalgia have not been widely studied. Systemic contact allergy can present with muscle and joint pain and general malaise. The aim of this study is to investigate contact allergy rates in individuals with fibromyalgia to the sensitizers in an extended dental series and compare with control groups. Co
In the fields of behavioural and psychological research, pupil size and skin conductance are two variables that provide useful information about a participant’s state of mind at a given moment. Both variables are involuntary indicators of psychophysiological responses such as alertness, arousal, or focus. Pupil size is commonly measured with a video-based eye tracker, and skin conductance is measu
