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Nonstructural protein 1 (Nsp1) of SARS-CoV-2 inhibits host cell translation through an interaction between its C-terminal domain and the 40S ribosome. The N-terminal domain (NTD) of Nsp1 is a target of recurring deletions, some of which are associated with altered COVID-19 disease progression. Here, we characterize the efficiency of translational inhibition by clinically observed Nsp1 deletion var

Background: Musculoskeletal pain and its risk factors are rarely assessed in studies on adolescent athletes. The aim was to identify risk factors at baseline that were associated with the persistence or development of musculoskeletal pain at a two-year follow-up in adolescent sport school students, and to study cross-sectional associations at follow-up between musculoskeletal pain and sports perfo

Despite global scientific consensus, climate change is a highly controversial and politicized issue in the United States. Grounded in two quantitative survey iterations with approximately 446 responses, 28 semi-structured interviews, and 4 focus groups with 60 undergraduate students from six state universities in the Appalachian region, this five-year study explores the role of place-based attachm

Objective: To examine the clusters of chronic conditions present in people with osteoarthritis and the associated risk factors and health outcomes. Methods: Clinical Practice Research Datalink (CPRD) GOLD was used to identify people diagnosed with incident osteoarthritis (n = 221,807) between 1997 and 2017 and age (±2 years), gender, and practice matched controls (no osteoarthritis, n = 221,807) f

The Origenist controversy at the end of the fourth century was largely played out within a monastic context, and had, moreover, an immediate and extensive impact on the movement. In spite of this, studies of the controversy and its causes have mainly focused on the dogmatic issues foregrounded in the controversy, neglecting the more fundamental issues about why the legacy of Origen was important,

Background: Per- and polyfluoroalkyl substances (PFAS) are a large family of persistent industrial chemicals with endocrine disrupting properties. Objectives: To examine biomarkers of reproductive function in young adult males according to current environmental exposure to single and combined PFAS. Methods: The study population consisted of young men (n = 1041, age 18–21) from the Fetal Programmin

This work aims to analyze thermal performance for an electric heater filled with different nanofluids, including SiO2-water nanofluid, Fe3O4-water nanofluid, and Cu-water nanofluid. The effect of nanoparticle concentration (0.1–2.0 wt%) is also discussed. Results indicate that Cu-water nanofluids show better heat transfer performance than the other nanofluids. The highest heating efficiency for th

In this study an algorithm was developed for calculating maximum detectable distance (MDD) for mobile gamma-ray detection of lost sources in-situ for some common mobile spectrometer systems and gamma sources (137Cs and 60Co). The MDD is a function of detector efficiency, vehicle speed, acquisition time interval, radiation background level and accepted frequency of false alarms. To test its accurac

The oxido-bridged diiron(III) complex [Fe2(μ-O)(μ-OAc)(DPEAMP)2](OCH3) (1), based on a new unsymmetrical ligand with an N4O donor set, viz. [2-((bis(pyridin-2-ylmethyl)amino)methyl)-6-((ethylamino)methyl)-4-methylphenol (HDPEAMP)], has been prepared and characterized by spectroscopic methods and X-ray crystallography. The crystal structure of the complex reveals that each Fe(III) ion is coordinate

In this study, a plant-wide model describing the fate of C, N and P compounds, upgraded to account for (on-site/off-site) greenhouse gas (GHG) emissions, was implemented within the International Water Association (IWA) Benchmarking Simulation Model No. 2 (BSM2) framework. The proposed approach includes the main biological N2O production pathways and mechanistically describes CO2 (biogenic/non-biog

Only well-maintained railway systems can function without severe interruptions. However,maintenance activities can themselves cause train delays if they conflict with trainmovements. Trackwork refers to maintenance performed on a railway track. This studyaims to investigate the effect of trackwork on train delays in Sweden. It presents a logisticregression analysis based on more than 225,000 plannOnly well-maintained railway systems can function without severe interruptions. However, maintenance activities can themselves cause train delays if they conflict with train movements. Trackwork refers to maintenance performed on a railway track. This study aims to investigate the effect of trackwork on train delays in Sweden. It presents a logistic regression analysis based on more than 225,000 p

The fourth enzymatic reaction in the de novo pyrimidine biosynthesis, the oxidation of dihydroorotate to orotate, is catalyzed by dihydroorotate dehydrogenase (DHODH). Enzymes belonging to the DHODH Class II are membrane-bound proteins that use ubiquinones as their electron acceptors. We have designed this study to understand the interaction of an N-terminally truncated human DHODH (HsΔ29DHODH) an

Train delays are often monitored using lag indicators of achieved punctuality levels, but indicators can also be used proactively aslead indicators to help reach a certain level of punctuality. In this paper, two lead indicators – the share of delayed dwell times andthe share of delayed run times – are formulated and tested on Swedish commuter train data for the years 2001-2020. Results showthat iTrain delays are often monitored using lag indicators of achieved punctuality levels, but indicators can also be used proactively as lead indicators to help reach a certain level of punctuality. In this paper, two lead indicators – the share of delayed dwell times and the share of delayed run times – are formulated and tested on Swedish commuter train data for the years 2001-2020. Results show tha

We consider the fundamental problem of assigning distinct labels to agents in the probabilistic model of population protocols. Our protocols operate under the assumption that the size n of the population is embedded in the transition function. Their efficiency is expressed in terms of the number of states utilized by agents, the size of the range from which the labels are drawn, and the expected n

Background:Traditional primary care is characterized by patient consultations via phone and physical visits. However, the current development in Swedish primary care is to blend digital solutions with traditional solutions. This paper addresses this development by examining the normalization of embedding and integrating a digital health care platform into everyday care routines in a primary care cBackground:Traditional primary care is characterized by patient consultations via phone and physical visits. However, the current development in Swedish primary care is to blend digital solutions with traditional solutions. This paper addresses this development by examining the normalization of embedding and integrating a digital health care platform into everyday care routines in a primary care c