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Apart from the relevant lipid-lowering effects, statins have demonstrated significant, although heterogeneous, anti-tumor activities in preventing breast cancer (BC) progression. To characterize the critical pathways behind the diverse responses to therapy, we investigated statin-induced changes in regulation of lipid metabolism and abundance of neutral lipid-containing cytoplasmic lipid droplets

The detailed mechanisms of progressive intensification of seizures often occurring in epilepsy are not well understood. Animal models of kindling, with progressive intensification of stimulation-induced seizures, have been previously used to investigate alterations in neuronal networks, but has been obscured by limited recording capabilities during electrical stimulations. Remote networks in kindl

In this paper we suggest an algorithm for estimation of the parameters detailing Oscillating Gaussian functions. The different components of the signal are first detected in the spectrogram. After this we exploit the fact that a Gaussian function may be perfectly reassigned into one single point given a correct scaling factor, where this scaling factor is a function of the unknown shape parameter

Diesel engines are by far the most common means of propulsion aboard ships. It is estimated that around half of their fuel energy consumption is dissipated as low-grade heat. The organic Rankine cycle technology is a well-established solution for the energy conversion of thermal power from biomass combustion, geothermal reservoirs, and waste heat from industrial processes. However, its economic fe

A novel constitutive framework suitable for material interfaces undergoing large deformations in a geometrically exact setting was developed in Ottosen et al. (2016). In contrast to previous works, it permits the description of arbitrary material anisotropies by fulfilling all fundamental balance laws in physics as well as the principle of material objectivity. This paper deals with an efficient f

The global carbon cycle is highly sensitive to climate-driven fluctuations of precipitation, especially in the Southern Hemisphere. This was clearly manifested by a 20% increase of the global terrestrial C sink in 2011 during the strongest sustained La Niña since 1917. However, inconsistencies exist between El Niño/La Niña (ENSO) cycles and precipitation in the historical record; for example, sign

Eddy covariance (EC) measurements are often used to validate net ecosystem productivity (NEP) estimated from satellite remote sensing data and biogeochemical models. However, EC measurements represent an integrated flux over their footprint area, which usually differs from respective model grids or remote sensing pixels. Quantifying the uncertainties of scale mismatch associated with gridded flux

This study analyzed the change in nanomechanical properties of ultrafiltration hollow fiber membranes harvested from pilot-scale units after twelve months of operation. Quantitative Nanomechanical Mapping technique was used to distinguish between adhesion, dissipation, deformation, and modulus while simultaneously generating a topographic image of membranes. Nanomechanical maps of virgin membranes

Ecosystems worldwide are facing habitat homogenization due to human activities. Although it is commonly proposed that such habitat homogenization can have negative repercussions for ecosystem functioning, this question has yet to receive explicit scientific attention. We expand on the framework for evaluating the functional consequences of biodiversity loss by scaling up from the level of species

Nitrogenase activity (NA) in shallow‐water (< 1 m) sediments was investigated at 60 randomly selected sites along a 150 km stretch on the brackish‐water Swedish west coast, without targeting any specific type of sediments, such as microbial mats. Benthic nitrogen (N) fixation and diazotrophs (nifH genes) were found at all sites, regardless of the presence of cyanobacterial or microbial mats. The m

This study is the first to estimate the effect of Agri-Environmental Schemes (AES) on nutrient runoff using abatement data and water samples on a large scale. This unique combination of data sources identifies all farms located upstream from a given water sampling site. By using watersheds that cover 91% of the Swedish land area and AES payments to 83% of Swedish farms, the study is almost a full

In recent years, many cities have joined transnational municipal climate networks (TMCNs), which were set up in response to climate change. Despite the fact that some of these TMCNs have been active for more than two decades, there has been no systematic investigation of the networks' impact on local climate governance. In this article we attempt to answer if and how local climate governance has b

Detta är den sjätte årsrapporten från Svensk Dagfjärilsövervakning, ett nationelltmiljöövervakningsprogram som koordineras av Lunds universitet på uppdrag avNaturvårdsverket sedan 2010. Svensk Dagfjärilsövervakning är ett samarbete mellan Sveriges Entomologiska Förening, Naturvårdsverket, Lunds universitet, Sveriges lantbruksuniversitet och Länsstyrelserna. Verksamheten möjliggörs av frivilliga laThis is the sixth annual report of the Swedish Butterfly Monitoring Scheme, a national monitoring programme coordinated by Lund University for the Swedish Environmental Protection Agency since 2010. The programme is a partnership between the Entomological Society of Sweden, the Swedish Environmental Protection Agency, Lund University, the Swedish University of Agricultural Sciences and the Swedish

Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(IV) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remarkable correlation between logkRS− and the thiol dissociation constants pKRSH is disclosed: logkRS− = (0.50 ± 0.02)pKRSH + (0.68 ± 0.13), where kRS− de

This study explores how cognitive heterogeneity at the team level-i.e., the degree to which team members adhere to conflicting cognitive frames-impacts entrepreneurial learning behavior. We analyze learning processes in a new-venture team over three time-periods, leveraging rich data from 20 interviews, 990 emails, and 62 internal documents. We find that during time-periods when the team encompass

Sauna sessions and winter swimming are traditional and popular recreational activities in certain countries. Their positive effects on health and relaxation, both as separate and combined activities, are commonly reported. However, systematic studies of these effects are relatively scarce, especially regarding the nonlinear analysis of the physiological measurements of the heart activity. We perfo

Modern wind turbines are designed to withstand approximately for a lifetime of 20 years [1]. However, a very long design life of 100 years or more can be expected for high-quality concrete foundations. Thus there is a big difference in lifetime between wind turbines and foundations. There is a significant economic benefit of replacing the out-of-date wind turbine with a new turbine of better power

The STAFF III database was acquired with the aim of better understanding the ECG signatures observed during acute ischemia, with special focus on high-frequency QRS components. The database contains recordings from 104 patients undergoing elective balloon percutaneous coronary intervention. The database has not only been analyzed in numerous clinical studies, but also turned out to be an excellent