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New developments in virtual reality-assisted treatment of aggression in forensic settings: The case of VRAPT

Aggression is a known problem in individuals being cared for in forensic settings, yet the evidence base for its treatment is scarce. Virtual Reality (VR) has been proposed as a promising addition to interventions in forensic settings, as it may increase the motivation among participants, bridge the gap between real life, therapeutic and laboratory experiences, and increase the ecological validity

Cross-reactivity of antibody responses to Borrelia afzelii OspC : Asymmetry and host heterogeneity

The tick-transmitted bacterium Borrelia afzelii consists of a number of antigenically different strains — often defined by outer surface protein C (OspC) genotype — that coexist at stable frequencies in host populations. To investigate how host antibody responses affect strain coexistence, we measured antibody cross-reactivity to three different OspC types (OspC 2, 3 and 9) in three different stra

Deep learning reconstruction of digital breast tomosynthesis images for accurate breast density and patient-specific radiation dose estimation

The two-dimensional nature of mammography makes estimation of the overall breast density challenging, and estimation of the true patient-specific radiation dose impossible. Digital breast tomosynthesis (DBT), a pseudo-3D technique, is now commonly used in breast cancer screening and diagnostics. Still, the severely limited 3rd dimension information in DBT has not been used, until now, to estimate

Longitudinal vibration interferes with cross-bridge attachment and prevents muscle fibre shrinkage under PSE-like conditions

The impact of longitudinal vibration on cross-bridge attachments between myofilaments was investigated in single fibres and intact muscle. Sinusoidal length vibration (frequency 50 Hz, amplitude 5% of fibre length) reduced active force by 40% when fibres were activated by elevation of [Ca2+], but did not alter the force when fibres were in rigor state. When vibrated for 30 min in rigor at pH 5.5 a

Decadal-scale subaerial beach and dune evolution at Duck, North Carolina

Thirty-nine years of high-resolution data from 1981 to 2019 surveyed by the Field Research Facility (FRF) of the US Army Corps of Engineers at Duck, North Carolina, in the United States, were analyzed for temporal and spatial characteristics of beach morphology evolution employing a range of statistical methods. In the study, emphasis was put on the response of the subaerial part of the beach prof

Transcriptomic responses of saline-adapted Nile tilapia (Oreochromis niloticus) to rearing in both saline and freshwater

The Nile tilapia, Oreochromis niloticus, is an important species for global aquaculture. Recently, a single genetic line of Nile tilapia was developed using estimated breeding values (EBVs) for body weight under moderately saline water that showed significant improvement in growth performance. To explore the molecular mechanisms underlying this enhanced growth capacity, RNA-Seq was used to profile

Phosphorus burial in vivianite-type minerals in methane-rich coastal sediments

Sediments are a key sink for phosphorus (P) in coastal systems. This allows coastal areas to act as a filter for P that is transported from land to sea. Recent work suggests that vivianite-type ferrous iron (Fe(II))-P minerals may be more important as a sink for P in coastal sediments than previously thought. Here, we investigate the occurrence of such vivianite-type minerals in sediments of three

β-Mannanase BoMan26B from Bacteroides ovatus produces mannan-oligosaccharides with prebiotic potential from galactomannan and softwood β-mannans

Galactomannan (GM) in legumes and acetyl-galactoglucomannan (AcGGM) in softwoods are wide-spread β-mannans. Their depolymerisation is catalyzed by β-mannanases. We have investigated a cell-surface exposed and galactose-tolerant β-mannanase (BoMan26B) from the abundant gut bacterium Bacteroides ovatus. Glycosidases from the gut microbiota have potential for production of prebiotics, such as dietary

Evaluation of different coatings of the tibial tray in uncemented total knee arthroplasty. A randomized controlled trial with 5 years follow-up with RSA and DEXA

Background: Regenerex® is a porous titanium construct with a 3D interconnecting pore structure and biomechanical characteristics close to that of normal trabecular bone. This study aimed to compare the Regenerex (VR) to the non-interconnecting pore structure Porous Plasma Spray (VP) on tibial implants for total knee arthroplasty (TKA) at 5 years. Methods: We enrolled and randomized 61 patients (me

Self-Reported Shorter Than Desired Ejaculation Latency and Related Distress—Prevalence and Clinical Correlates : Results From the European Male Ageing Study

Background: Few data have looked at the occurrence and clinical correlates of self-reported shorter than desired ejaculation latency (rapid ejaculation, RE) and its related distress in the general population. Aim: To determine the prevalence and clinical correlates of self-reported RE and RE- related distress in middle age and older European men. Methods: Subjects were recruited from population sa

A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction : The COOL AMI EU Pivotal Trial

Background: Despite primary PCI (PPCI), ST-elevation myocardial infarction (STEMI) can still result in large infarct size (IS). New technology with rapid intravascular cooling showed positive signals for reduction in IS in anterior STEMI. Aims: We investigated the effectiveness and safety of rapid systemic intravascular hypothermia as an adjunct to PPCI in conscious patients, with anterior STEMI,

The historical process of commercialization of cities: the case of Stockholm 1900-2020

The aim of this paper is to outline a process-based approach to the historical trajectory of commercialising cities that can account for continuity and change in a city’s image. Previous research involving historical approaches to the commercialisation of places are typically underpinned by a view of history as linear and chronological. By contrast, the present study adopts a performative view of

Chaotic resonant dynamics and exchanges of energy in Hamiltonian PDEs

The aim of this note is to present the recent results in [16] where we provide the existence of solutions of some nonlinear resonant PDEs on T2 exchanging energy among Fourier modes in a "chaotic-like" way. We say that a transition of energy is "chaotic-like" if either the choice of activated modes or the time spent in each transfer can be chosen randomly. We consider the nonlinear cubic Wave, the

Maximal subgroups of non-torsion Grigorchuk-Gupta-Sidki groups

A Grigorchuk-Gupta-Sidki (GGS-)group is a subgroup of the automorphism group of the p-regular rooted tree for an odd prime p, generated by one rooted automorphism and one directed automorphism. Pervova proved that all torsion GGS-groups do not have maximal subgroups of infinite index. Here we extend the result to non-torsion GGS-groups, which include the weakly regular branch, but not branch, GGS-

Navigating ethnicity, nationalism and Pan-Africanism – Kimbanguists, identity and colonial borders

The Kimbanguists, whose church is based on the healing and proclamation ministry of Simon Kimbangu in 1921 in the Belgian Congo, challenge colonially defined borders and identities in multiple ways. Anticolonialism is in the DNA of Kimbanguism, yet in a manner that contests the colonially inherited dichotomy between religion and politics. Kimbanguists draw from holistic Kongo traditions, where the

B lymphocyte specification is preceded by extensive epigenetic priming in multipotent progenitors

B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromo

Transglycosylation by β-mannanase TrMan5A variants and enzyme synergy for synthesis of allyl glycosides from galactomannan

Retaining β-mannanases are glycoside hydrolases (GHs) that can potentially be applied for synthesis of glycosides by catalysis of transglycosylation reactions. A novel active-site double mutant (R171K/E205D) of the catalytic module (CM) of the family GH5 Trichoderma reesei β-mannanase (TrMan5A) was expressed in Pichia pastoris and purified. TrMan5A, CM and CM-variants R171K and R171K/E205D had pH

GREAT-ITN and Gaia : Preparing for Science

This paper gives a brief overview of the Gaia Research for European Astronomy Training (GREAT) network, including a description of the GREAT-ESF Research Network Programme and the GREAT Initial Training Network (GREAT-ITN). Scientific highlights from the GREAT-ITN are noted.

An intermediate-band photometric study of the "globular cluster" NGC 2419

NGC 2419 is one of the remotest star clusters in the Milky Way halo and its exact nature is yet unclear. While it has traits reminiscent of a globular cluster, its large radius and suggestions of an abundance spread have fueled the discussion about its origin in an extragalactic environment, possibly the remnant of the accretion of a dwarf galaxy. Here, we present first results from deep intermedi