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Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a po
In this paper infinitesimal elasto-plastic based topology optimization is extended to finite strains. The employed model is based on rate-independent isotropic hardening plasticity and to separate the elastic deformation from the plastic deformation, use is made of the multiplicative split of the deformation gradient. The mechanical balance laws are solved using an implicit total Lagrangian formul
The Value of a Statistical Life (VSL) is a widely used measure of the value of mortality risk reduction. Since VSL should reflect preferences and attitudes to risk, there are reasons to believe that it varies depending on the type of risk involved. It has been argued that cancer should be considered a “dread disease”, which supports the use of a “cancer premium”. The objective of this study is to
For the assessment of value of new therapies in healthcare, Health Technology Assessment (HTA) agencies often review the cost per Quality-Adjusted Life-Years (QALY) gained. Some HTAs accept a higher cost per QALY gained when treatment is aimed at prolonging survival for patients with a short expected remaining lifetime, a so called End-Of-Life (EoL) premium. The objective of this study is to elici
Alt a 1 is a highly allergenic protein from Alternaria fungi responsible for several respiratory diseases. Its crystal structure revealed a unique β-barrel fold that defines a new family exclusive to fungi and forms a symmetrical dimer in a butterfly-like shape as well as tetramers. Its biological function is as yet unknown but its localization in cell wall of Alternaria spores and its interaction
Multiplicity-correlation measurements provide insight into the dynamics of high-energy collisions. Models describing these collisions need these correlation measurements to tune the strengths of the underlying QCD processes which influence all observables. Detectors, however, often possess limited coverage or reduced efficiency that influence correlation measurements in obscure ways. In this paper
Objective Bayesians hold that degrees of belief ought to be chosen in the set of probability functions calibrated with one’s evidence. The particular choice of degrees of belief is via some objective, i.e., not agent-dependent, inference process that, in general, selects the most equivocal probabilities from among those compatible with one’s evidence. Maximising entropy is what drives these infere
Retired Lutheran pastor Ambilikile Mwasapila became the most celebrated healer in Eastern Africa for half a year in 2011. His healing consists of an herbal potion, brewed according to the recipe he got from God in dreams. According to Rev. Mwasapila, the potency of the medicine stems from the presence of the Word of God in it. It is efficient only when administered by him. He perceives himself as
Strong-field phenomena driven by an intense infrared (IR) laser depend on during what part of the field cycle they are initiated. By changing the sub-cycle character of the laser electric field it is possible to control such phenomena. For long pulses, sub-cycle shaping of the field can be done by adding a relatively weak, second harmonic of the driving field to the pulse. Through constructive and
It is of contemporary interest to fabricate nanowires having quantum confinement and one-dimensional subband formation. This is due to a host of applications, for example, in optical devices, and in quantum optics. We have here fabricated and optically investigated narrow, down to 10 nm diameter, wurtzite GaAs nanowires which show strong quantum confinement and the formation of one-dimensional sub
We evaluate the capability of the global atmospheric transport model TM5 to simulate the boundary layer dynamics and associated variability of trace gases close to the surface, using radon (222Rn). Focusing on the European scale, we compare the boundary layer height (BLH) in the TM5 model with observations from the National Oceanic and Atmospheric Admnistration (NOAA) Integrated Global Radiosonde
A method is presented to infer cloud liquid water path (LWP in kg/m2) over the ocean from passive microwave measurements of SSM/I. The algorithm to retrieve LWP is based on simulated satellite observations. They are calculated with a radiative transfer model applied to about 3000 radiosonde ascents over the Atlantic Ocean. Since radiosonde observations do not contain direct information about cloud
Kombinerad kortbiografi över lundaalumnen och skolmannen Carl Sprinchorn (1851-1927) och redogörelse för hur vattenväxten sjönöt (vilken Sprinchorn återupptäckt i Sverige) kom att utrotas, främst till följd av botaniska samlare.
The present thesis explores Japanese imperative constructions from a general linguistic perspective, as well as examining the imperative as a cross-linguistic object of study. On the definitional side, a terminological apparatus for the description and analysis of imperatives and directives is presented. It includes the proposal that the range of conventional directive strategies in a language be
Since I finished my PhD thesis in June 2014, I have lived a stimulating but also somewhat precarious life at Lund University. It is no secret that permanent teaching positions are hard to come by, and during the time I have been teaching as temporary staff on a number of different courses, I have started to consider what the lack of permanent positions means for the pedagogical work carried out at
