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Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia

Loss of appetite and negative energy balance are common features of endotoxemia in all animals and are thought to have protective roles by reducing nutrient availability to host and pathogen metabolism. Accordingly, fasting and caloric restriction have well-established anti-inflammatory properties. However, in response to reduced nutrient availability at the cellular and organ levels, negative ene

LTE NLOS Navigation and Channel Characterization

Navigation with terrestrial wireless infrastructure is appealing to overcome geometrical limitations of satellite navigation for users in environments with limited sky views. However, terrestrial signals are also prone to multipath that can result in angular and range estimates that are not representative of actual transmitter-receiver geometry. In this paper, some of these propagation effects are

Nutrient and Silicon Isotope Dynamics in the Laptev Sea and Implications for Nutrient Availability in the Transpolar Drift

Realistic prediction of the near-future response of Arctic Ocean primary productivity to ongoing warming and sea ice loss requires a mechanistic understanding of the processes controlling nutrient bioavailability. To evaluate continental nutrient inputs, biological utilization, and the influence of mixing and winter processes in the Laptev Sea, the major source region of the Transpolar Drift (TPD)

Individual tree detection from unmanned aerial vehicle (UAV) derived point cloud data in a mixed broadleaf forest using hierarchical graph approach

Studying individual trees is a common way that scientists employ to study forests and estimate forest parameters. In this study, a graph-based approach was developed for detecting individual trees in a broadleaf, complex forest region based on UAV-derived point cloud data. Horizontal cross-sections at different heights were applied to the Canopy Height Model (CHM) to extract initial candidates for

The vertical light-gradient and its potential impact on animal distribution and behavior

The visual environment provides vital cues allowing animals to assess habitat quality, weather conditions or measure time of day. Together with other sensory cues and physiological conditions, the visual environment sets behavioral states that make the animal more prone to engage in some behaviors, and less in others. This master-control of behavior serves a fundamental and essential role in deter

Semi-global Chemical Kinetic Mechanism for FAME Combustion Modeling

Modeling of combustion engines using computational fluid dynamics (CFD), to investigate and improve performance of biodiesel combustion, calls for development of small and efficient chemical kinetics mechanisms that accurately represent ignition and flame propagation of renewable fuels. In this work, a semi-global approach is used to develop a mechanism suitable for three-dimensional CFD of fatty

Search, save and share: family historians’ engagement practices with digital platforms

Alongside established heritage institutions, family historians are central figures in the ecosystem of digital heritage, both as contributors to and users of digitized historical sources. With that in mind, this research aims for a wide examination of family historians’ engagement with the broader selection of available digital platforms, providing knowledge about how and why they choose to use on

Older Adults Living in Disadvantaged Areas : Protocol for a Mixed Methods Baseline Study on Homes, Quality of Life, and Participation in Transitioning Neighborhoods

BACKGROUND: Swedish policy states that older adults should be able to age safely with continued independence and lead active lives. However, this plays out differently in different Swedish municipalities depending upon degree of demographic change, globalization, and urbanization. Internationally, older adults living in disadvantaged areas have worse physical and mental health, activity restrictio

Subalgebras in K[x] of small codimension

We introduce the concept of subalgebra spectrum, Sp(A), for a subalgebra A of finite codimension in K[x]. The spectrum is a finite subset of the underlying field. We also introduce a tool, the characteristic polynomial of A, which has the spectrum as its set of zeroes. The characteristic polynomial can be computed from the generators of A, thus allowing us to find the spectrum of an algebra given

Solo mothers’ by choice experiences during pregnancy and early parenthood : Thoughts and feelings related to maternal health-services

The present study examined the thoughts and feelings of solo mothers by choice (SMC) regarding their experiences during pregnancy and early parenthood, with special focus on their contact with maternal health-services (MCHS). Semi-structured interviews were carried out with solo mothers (N = 10) who had undergone assisted fertilization in Sweden. Thematic analysis revealed two main themes. The fir

Incidental pulmonary embolism in patients with cancer : prevalence, underdiagnosis and evaluation of an AI algorithm for automatic detection of pulmonary embolism

Objectives: To assess the prevalence of reported and unreported incidental pulmonary embolism (iPE) in patients with cancer, and to evaluate an artificial intelligence (AI) algorithm for automatic detection of iPE. Methods: Retrospective cohort study on patients with cancer with an elective CT study including the chest between 2018-07-01 and 2019-06-30. All study reports and images were reviewed t

Association Between Dietary Habits in Midlife With Dementia Incidence Over a 20-Year Period

BACKGROUND AND OBJECTIVES: Dementia cases are expected to triple during the next 30 years, highlighting the importance of finding modifiable risk factors for dementia. The aim of this study is to investigate whether adherence to conventional dietary recommendations or to a modified Mediterranean diet are associated with subsequent lower risk of developing all-cause dementia, Alzheimer's disease (A

Blood lead levels and risk of atherosclerosis in the carotid artery : Results from a swedish cohort

BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrat

Shared language is essential : Communication in a multiethnic obstetric care setting

This study focuses on communication and conceptions of obstetric care to address the postulates that immigrant women experience sensitive care through the use of an ethnically congruent interpreter and that such women prefer to meet health providers of the same ethnic and gender profile when in a multiethnic obstetrics care setting. During 2005-2006, we conducted in-depth interviews in Greater Lon

Experimental Validation of Single Base Station 5G mm Wave Positioning : Initial Findings

5G cellular networks can utilize millimeter wave signals, and support large bandwidths and large antenna arrays, which provide more geometric-based signals and higher delay and angle resolutions. These merits bring new opportunities in positioning the user with limited infrastructure through the use of combined angle and delay information. However, there are many practical challenges to overcome,

High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction

Background: The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods: From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute ches