Tapasin (tpn), an essential component of the MHC class I (MHC I) loading complex, has a canonical double lysine motif acting as a retrieval signal, which mediates retrograde transport of escaped endoplasmic reticulum (ER) proteins from the Golgi back to the ER. In this study, we mutated tpn with a substitution of the double lysine motif to double alanine (GFP-tpn-aa). This mutation abolished inter

High-spin states in Br-72(35)37 were studied using the Ca-40(Ar-36,3pn) reaction. The existing level scheme has been significantly modified and extended. Evidence has been found for a spin reassignment of -1h to the previously observed negative-parity band, which carries implications for the interpretation of a signature inversion in this structure. One signature of the previously assigned positiv

In the present thesis, the influence of the immunosuppressive drug FK506 on mitogen-induced changes in the expression of subunits a and ß of the IL-2 receptor by isolated human peripheral blood mononuclear cells has been studied. Up-regulation and release of the a-chain were potently depressed by FK506, even in the presence of exogenous IL-2. In contrast, up-regulation of the ß-chain on these same

Defining, prioritizing, and selecting requirements are problems of tremendous importance. In this paper, a new approach called Quantitative WinWin for decision support in requirements negotiation is studied. The difference to Boehm's WinWin groupware-based negotiation support is the inclusion of quantitative methods as a backbone for better and more objective decisions. Like Boehm's original WinWi

Popular Abstract in Swedish Kvinnor begär lägre lön än män i löneförhandlingar. Könsskillnader i förhandlingsprestation har nyligen förklarats som en stereotyphotseffekt. Enligt stereotype threat theory kan prestationen hos negativt stereotyperade gruppmedlemmar tillfälligt försämras i kontexter där den negativa stereotypen är framträdande. Kvinnor stereotyperas som dåliga förhandlare, jämfört medWomen ask for less salary than men in negotiations. Sex differences in negotiating performance have recently been explained as stereotype threat effects. Stereotype threat theory states that the performance of negatively stereotyped group-members can suffer in contexts where the negative stereotype is salient. Women are stereo¬typed as bad negotiators, compared to men, and previous research has sh

Heat transfer is one of the most important and most common engineering disciplines in food processing. There are many unit operations in the food industry where steady or unsteady state heat transfer is taking place. These operations are of primary importance and affect the design of equipment as well as safety, nutritional and sensory aspects of the product. The chapters in this book deal mainly

Our investigation of two EPR and waste management programs in California, U.S. revealed two common features: involvement of the state government is small, and the establishment of concrete recycling/waste management systems is to a large extent left in the hands of entities who have direct responsibility for their implementation. Based on the degree of government involvement, we categorized recycl

Var finns naturen och hur upplever vi den? Vad är meningen med naturen och hur skapas denna mening? Vad är skillnaden mellan natur och miljö och vad blir konsekvenserna om man tar fasta på hur denna skillnad uppstått? Detta är frågor som rör naturens kulturhistoria och kulturisering. Ur ett internationellt perspektiv har intresset för naturens kulturella konstruktion vuxit fram under de senaste de

Popular Abstract in Swedish Det finns en skillnad mellan historia som vetenskap och historia som historiskt minne, som boken vill fästa uppmärksamhet på. Ådalen som motbild till det trygga Folkhemmet är en bild av hur vi kan uppleva verkligheten. Inte nödvändigtvis hur den såg ut. Vår uppfattning om vad som hänt kan vaa nog så verklig när vi handlar, agerar och tolkar omvärlden. Det är denna tolknThe prelude to this thesis is provided by the dramatic scenes that took place in Ådalen. During a demonstration, four men and one young woman were shot to death and five others injured by military troops ordered to Lunde harbour. Inspired by a number of other researchers (Koselleck, Samuel, Somers, Stråth, Södring, Jensen and Burke, to name a few), my investigation has analysed how the story of th

Popular Abstract in Swedish Denna doktorsavhandling vill belysa och öka kunskapen om beröringsundvikande. Beröringsundvikande är inte ett enkelt index på hur mycket en person berör eller undviker att bli berörd, utan ett tecken på en persons djupt rotade attityder gentemot beröring, jämförbart med en personlighetsegenskap. Avhandlingsarbetet tar sin teoretiska utgångspunkt från anknytningsteorin,The studies in this doctoral thesis investigated the concept of touch avoidance. Touch avoidance indicates a person’s negative affect toward physical contact/touch. In study 1 the aim was to develop a questionnaire that measures the level of touch avoidance. The results showed that touch avoidance can be measured along five different dimensions. The results are discussed in relation to attachment

This paper is a survey of how linear attacks can be applied on stream ciphers. It gives an overview of the development of linear attacks and a short theoretical explanation on how a linear attack on a stream cipher is typically launched today. The main part of the paper is then a more detailed description of the application of linear attacks on three stream cipher designs, namely Grain, Pomaranch,

Popular Abstract in Swedish Under de senaste årtiondena har vattenfärgen i många svenska sjöar och vattendrag ökat. Detta innebär att vattnet blir brunare, och detta fenomen benämns därför brunifiering. Brunifiering är inget unikt för Sverige, utan förekommer på åtskilliga ställen på norra halvklotet. Brunifieringen påverkar det akvatiska ekosystemet och vattnets potentiella samhällsnytta. Ur en eThe term brownification refers to the trend of increasing water color, i.e. the water becoming browner, which has been observed throughout the northern hemisphere over the last decades. Brownification has both ecological and societal implications. From an ecological point of view the impaired light climate may e.g. reduce aquatic primary production and affect predator-prey interactions within the

The novel "Reflexer" (Reflections) is the first novel in Swedish literature with a transgender person as the main character. "Reflexer" is a coming-out-novel before the genre was invented and deals with both sexual and gender identities in the early 20th century Sweden. "Reflexer" can thematically be linked to our contemporary LGBTQ literature.

Cooling is essential in all modern high-temperature gas turbines. Turbine cooling is mainly a function of gas entry temperature, which plays the key role in overall gas turbine performance. High turbine entry temperatures can be achieved through appropriate selection of blade cooling method and blade material. The semi-closed oxy-fuel combustion combined cycle (SCOC-CC) operates at the same high e