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Background: Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR standing committee for clinical trials met in 1998 to determine the methodological and logistical approach required for the development of evidence-based guidelines for treatment of knee OA. The guidelines were restricted to cover all currently available therapies for knee OA
Osteoarthritis is a heterogeneous and multifactorial disease with many pathogenic mechanisms implicated in its development and progression. Although osteoarthritis is a manifestation of certain metabolic, mechanical or inflammatory events, several distinct forms of osteoarthritis are inherited as dominantly acquired Mendelian traits. Gathering evidence is showing that inheritance and possible muta
Objective. To compare the responsiveness of the Functional Assessment System (FAS), the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the Medical Outcomes Study 36-item Short Form (SF-36) in patients with osteoarthritis (OA) scheduled for total hip replacement. Method. Twenty patients with a mean age at surgery of 72.6 years, with primary OA of the hip, were investiga
Objective. To describe a large kinship with inherited hip osteoarthritis (OA) and its associated susceptibility locus. Methods. Four generations of a kinship with familial hip OA were identified and characterized by family history and by clinical, radiographic, and histopathologic examination. In the genome-wide search for a susceptibility locus, OA cases were defined as those who had undergone to
Background - Osteoarthritis (OA) is the most common joint disease encountered throughout Europe. A task force for the EULAR Standing Committee for Clinical Trials met in 1998 to determine the methodological and logistical approach required for the development of evidence based guidelines for treatment of knee OA. The guidelines were restricted to cover all currently available treatments for knee O
Osteonecrosis of the femoral head often results in secondary osteoarthritis of the hip joint; however, the pathologic processes underlying the destruction of articular cartilage are not fully understood. Molecular markers in the hip joint fluids were measured to examine the changes in turnover of cartilage and other joint tissues. Marker data were related to clinical, radiological, and histopathol
We have carried out a prospective, longitudinal 30-year review of 95 adolescents who underwent total meniscectomy in one knee, and have compared the results with those observed 13 years earlier. All the medical records were scrutinized. Of the 63 patients reviewed clinically, 47 reported decreased sporting activity, although subjective satisfaction rose by 3% to 71%. The scores on the WOMAC ostcoa
Objective. To assess, in a population-wide study in Iceland, the genetic contribution to hip osteoarthritis (OA) leading to total hip replacement (THR). Methods. Information from 2 population-based databases in Iceland was combined: a national registry of all THRs performed between 1972 and 1996, and a genealogy database of all available Icelandic genealogy records for the last 11 centuries. A gen
To our knowledge, this is the first prospective study using validated questionnaires to assess patient-relevant outcomes after arthroscopic partial meniscectomy. Data from the Knee Injury and Osteoarthritis Outcome Score (KOOS), the SF-36 Medical Outcomes Study Short-Form Health Survey, and the Lysholm Knee Scoring Scale were available for 74 consecutive patients (50 males, 24 females; mean age, 4
Objective: To validate the WOMAC Osteoarthritis Index for use in Sweden. Methods: Test-retest reliability, internal consistency, validity, and responsiveness was determined in 52 patients (mean age 48 (20-69)) with arthroscopically assessed cartilage damage of the tibio-femoral knee joint. Results: All WOMAC scales were internally consistent with Cronbach's alpha coefficients of 0.83, 0.87, and 0.
Objective. To determine the concentrations of aggrecan fragments in synovial fluid from patients with knee joint injury, osteoarthritis (OA), or acute pyrophosphate arthritis (PPA; pseudogout), and to test their relative reactivity with the 846 epitope, a putative marker of cartilage aggrecan synthesis. Methods. Samples of knee joint fluid from 385 patients and 9 healthy-knee volunteers were obtai
Sustainability and the Political Economy of Welfare raises the issue of what is required to make welfare societies ecologically sustainable. Consisting of three parts, this book regards the current financial, economic and political crisis in welfare state institutions and addresses methodological, theoretical and wider conceptual issues in integrating sustainability. Furthermore, this text is conc
Rapid and powerful host defense mechanisms are essential in order to overcome harmful actions of pathogenic bacteria. Antimicrobial peptides (AMPs) and proteins are vital effector molecules of the fast-acting innate immune system and exist virtually in all living organisms. They exert a broad spectrum of natural antibiotic activity, but also play important immunomodulatory functions in the host. D
Rapport från ett seminarium sept. 2014 i Manama i Zimbabwe, om diakonens identitet i Lutherska kyrkan i Zimbabwe och i Sverige, två år efter den första vigningen (ordinationen) av diakoner i Evangelical Lutheran Church in Zombabwe.Report from a seminar i Manama in Zimbabwe September 2014: "The Identity of the Deacon in Zimbabwe and Sweden", two years after the first ordination of deacons in the Evangelical Lutheran Church in Zimbabwe (ELCZ).
Iran is a large country in the Middle East, which is an extremely arid region. Like its neighbors, severe droughts and population growth have intensified Iran’s water shortage problems in the past two decades. Furthermore, climate change has the potential to impose additional economic and social pressure on it and all Middle Eastern countries. Thus, how future climate change will interact with soc
