The non-peptide ET-receptor antagonist Bosentan was used to investigate the role of endogenous endothelin-1 (ET-1) in the development of the Sephadex-induced lung inflammation in the rat. Intratracheal instillation of Sephadex caused a 60-fold rise in endothelin-1-like-immunoreactivity (ET-1-LI) in bronchoalveolar lavage fluid (BALF) concomitant with development of lung oedema, an influx of inflam

1. Several recent in vitro studies have suggested that production of nitric oxide (NO) from the islet NO system may have an important regulatory influence on the secretion of insulin and glucagon. In the present paper we have investigated, mainly with an in vivo approach, the influence and specificity of the NO synthase (NOS) blocker NG-nitro-L-arginine methyl ester (L-NAME) on L-arginine-induced

The title compound, [PdBr(C24H49P2)], has a distorted square-planar coordination geometry with the P, C, P'-tridentate ligand forming two five-membered chelate rings. The Br atom is displaced from the square plane by 0.560 (6) angstrom.

We consider the problem of finding a long, simple path in an undirected graph. We present a polynomial-time algorithm that finds a path of length Omega((log L/log log L)(2)), where L denotes the length of the longest simple path in the graph. This establishes the performance ratio O(n( log log n/log n)(2)) for the longest path problem, where n denotes the number of vertices in the graph.

Dyschondrosteosis (DCO; also called Leri-Weill syndrome) is a skeletal dysplasia characterised by disproportionate short stature because of mesomelic shortening of the limbs. Madelung deformity is a feature of DCO that is distinctive, variable in expressivity and frequently observed. Mutations of the SHOX (short stature homeobox-containing) gene have been previously described as causative in DCO.

An account of the importance of the photographic documentation of the Nazi concentration camps for the reaction to and understanding of Nazism and the Holocaust.

In this paper we analyse an extremum controller based on a pulsetechnique. The idea is to superimpose probing pulses to the controlsignal and use for feedback the size of the pulse response in the output. Theprobing control strategy has been used with success forthe control of the substrate feeding in E. coli cultivations. The analysis is done here for systems ofHammerstein type with a piecewise a

W(+)W(-)gamma production at LEP2 is studied using data collected with the DELPHI detector at centre-of-mass energies between 189 GeV and 209 GeV, corresponding to an integrated luminosity of about 600 pb(-1). Cross-sections are measured for the production of W+W- with a hard, central and isolated photon in the final state, and are found to be compatible with the Standard Model prediction. The phot

Let X-1, X-2,... be independent and symmetric random variables such that S-n = X-1+...+ X-n converges to a finite valued random variable S a. s. and let S* = sup(1 = 94 and y >= 97, respectively. Although our results are derived primarily for symmetric random variables, they apply to non-negative variates and extend to an absolute value of a sum of independent but otherwise arbitrary random variab

Experimental studies of x-ray photoelectron and Co Lalpha x-ray emission spectra of the ZnS:Co semiconductor were carried out. It was established that Co ions are present in isovalent Co2+ configuration and that the Co 3d impurity states are localized above the top of the valence band by 1.0 +/- 0.2 eV.

This paper discusses the use of a transconductor, first proposed by Nauta for high frequency applications, in low frequency CMOS g(m) - C bandpass filters. The behavior of the transconductor is examined in detail, showing that the robust implementation of higher-order low-voltage filters is possible for center frequencies in the lower megahertz region. The experimental results are presented of the

Background and Purpose - The causes of death of patients with cerebral venous thrombosis (CVT) have not been systematically addressed in previous studies. We aimed to analyze the causes and predictors of death during the acute phase of CVT in the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) to identify preventable or treatable causes. Methods - ISCVT is a multinational,