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Purpose: Etoposide to standard R-CHOP is used for high-risk diffuse large B-cell lymphoma (DLBCL) in some countries. Due to the lack of randomized trials, a real-world data study using matching methods was used to test the potential effectiveness of R-CHOEP over R-CHOP. Patients and Methods: This study included patients from the Danish Lymphoma Register diagnosed between 2006 and 2020 at the age o

Artificial intelligence and Machine Learning (AI/ML) are steadily becoming widespread across all layers in the current mobile network generation. The next generation of networks, namely 6G, will consider AI/ML as a foundational block to deliver all expected results of such networks. Thus, the management of AI/ML applications across different layers of 6G is paramount for the success of the next ge

Bone is a complex hierarchical structure mainly comprising of a matrix of collagen and hydroxyapatite. The main physiological functions of bone include regulating skeletal remodeling, calcium homeostasis and providing a congenial environment to the bone marrow cells to reside and these physiological processes are intricately regulated by various cell types and biomolecules. During trauma to the sk

While misinformation has been around for centuries, the effects of online brand-related misinformation on consumers’ engagement remain tenuous. Addressing this gap, we develop the concept of online brand-related misinformation engagement, a consumer’s (e.g. cognitive/emotional) resource investment in their interactions with misinformation about brands. Recognizing the persuasive nature of misinfor

The prospect of death influences people’s thoughts about and how they deal with their remaining time. We aimed to understand whether patients with progressive, life-limiting diseases are oriented in the past, present, or future and how they deal with temporality. We conducted 57 in-depth interviews with end-of-life patients in 10 countries using thematic analysis at three levels (i.e., locally in

Ett oxymoron är ett uttryck bildat av motsatser, som talande tystnad, bitterljuv eller lysa med sin frånvaro. Morris Wikström ser hur ett kritiskt poetiskt grepp tagits över av totalitär politik.

We study the characteristic polynomial pn(x)=∏j=1n(|zj|-x) where the zj are drawn from the Mittag–Leffler ensemble, i.e. a two-dimensional determinantal point process which generalizes the Ginibre point process. We obtain precise large n asymptotics for the moment generating function E[euπIm\,lnpn(r)eaRe\,lnpn(r)], in the case where r is in the bulk, u ϵ R and a ϵ N. This expectation involves an n

This paper discusses how language training for refugees is implemented by the local authorities in Finland and Sweden. The responsibility, production and financing of this specific integration service, language training, is distributed over a multitude of actors in a multidimensional governance structure. We apply a conceptual framework based on intergovernmental relations and conflictual policy p

Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain repair, aiming to restore lost or damaged neurons. Proof-of-concept has been obtained from animal studies, yet these models do not efficiently recapitulate the complexity of the human brain, and further refinement is necessary before clinical tran

The effective material response as observed at a macro level is a manifestation of the material microstructure and lower scale processes. Due to their distinct atomic arrangement, compared to bulk material, grain boundaries significantly affect the electrical properties of metals. However, a scale-bridging understanding of the associated microstructure–property relation remains elusive so that phe

Aim Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive). Methods The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questio

Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain

This chapter aims to examine the impact of the international anticorruption agenda on the business and investment climate and legal culture in Uzbekistan. In undertaking this task, I specifically emphasise the daily life of anticorruption laws, policies, and agencies in Uzbekistan in order to understand how domestic institutions and actors perceive, interpret, negotiate, and challenge global antic

INTRODUCTION: We aimed to assess the impact of cholinesterase inhibitors (ChEIs) and memantine on cognition, major adverse cardiovascular events (MACE) and mortality in dementia with Lewy bodies (DLB). METHODS: A total of 1,095 incident DLB patients from the Swedish Registry on cognitive/dementia disorders were included. Using an inverse probability of treatment weighting, the effect of initiating

STUDY QUESTION: Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER: Organoid formation from testicular tissue collected from childhood cancer patients positively correlates with SRY-Box transcription factor 9 (SOX9) expression in Sertoli cells, which in turn negatively corr