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PURPOSESelumetinib can increase radioactive iodine (RAI) avidity in RAI-refractory tumors. We investigated whether selumetinib plus adjuvant RAI improves complete remission (CR) rates in patients with differentiated thyroid cancer (DTC) at high risk of primary treatment failure versus RAI alone.METHODSASTRA (ClinicalTrials.gov identifier: NCT01843062) is an international, phase III, randomized, pl

Dimethyl sulfide (DMS) is emitted by phytoplankton species in the oceans and constitutes the largest source of naturally emitted sulfur to the atmosphere. The climate impact of secondary particles, formed through the oxidation of DMS by hydroxyl radicals, is still elusive. This study investigates the hygroscopicity and cloud condensation nuclei activity of such particles and discusses the results

The time dependence of ice-nucleating particle (INP) activity is known to exist, yet for simplicity it is often omitted in atmospheric models as an approximation. Hitherto, only limited experimental work has been done to quantify this time dependency, for which published data are especially scarce regarding ambient aerosol samples and longer timescales. In this study, the time dependence of INP ac

Ice-core timescales are vital for the understanding of past climate; hence they should be updated whenever significant amounts of new data become available. Here, the Greenland ice-core chronology GICC05 was revised for the last 3835 years by synchronizing six deep ice cores and three shallow ice cores from the central Greenland ice sheet. A new method was applied by combining automated counting o

Rationale: Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective pharmacological therapies available for ALI are limited; identifying novel concepts in treatment is essential. GB0139 is a Gal-3 inhibitor currently under clinical investigation for the treatment of idiopathic pulmonary fibrosis. We investigate the role

Diverse approaches such as oscillating gradients, tensor-valued encoding, and diffusion-relaxation correlation have been used to study microstructure and heterogeneity in healthy and pathological biological tissues. Recently, acquisition schemes with free gradient waveforms exploring both the frequency-dependent and tensorial aspects of the encoding spectrum b(ω) have enabled estimation of nonpara

This study tested for an association between early cancer-related biomarkers and low-to-moderate exposure to fumes from welding mild steel. Methods Male, non-smoking participants from southern Sweden were recruited and examined (N=338, 171 welders and 167 controls); of these, 78 welders and 96 controls were examined on two occasions six years apart. Exposure to welding fumes was evaluated by measu

To provide more integrated care, several countries have implemented the Flexible Assertive Community Treatment (FACT) model. However, this model does not guarantee full integration, especially in complex and fragmented service systems like in Norway. Hence, we investigated which barriers that might reduce the potential for integrated care in the Norwegian system, as described by staff in FACT team

This study explores the experiences of Swedish upper secondary school chemistry students working with a socioscientific issue about per- and polyfluoroalkyl substances (PFAS) in everyday products, and how they perceive that this teaching has influenced them in their role as citizens in a democratic society. Data collection has been carried out on several occasions over a period of one and a half y

Azo dyes are recalcitrant organic pollutants present in textile industry effluents. Conventional treatment methods to remove them come with a range of disadvantages. Nanoparticles and their nanocomposites offer more efficient, less expensive and easy to handle wastewater treatment alternative. Methods. In this study, nanoparticles of nickel oxide (NiO-NPs), copper oxide (CuO-NPs) and their nanocom

AMP-activated protein kinase (AMPK) activation is considered a useful strategy for the treatment of type 2 diabetes (T2D). It is unclear whether the expression and/or activity of AMPK in adipocytes is dysregulated in obesity. Also, the expression/activity pattern of AMPKβ isoforms, which are targets for AMPK activators, in adipocytes remains elusive. In this study we show that the two AMPKβ isofor

Results from the application of a new seismic technique for non-destructive testing of pavement layer moduli are presented. The method is based on the multichannel analysis of surface waves (MASW) method and multichannel simulation with one receiver (MSOR). The MSOR method uses one accelerometer (receiver), a light hammer (source), and a single-channel recording device to generate a simulated mult