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Background: Autonomous systems have received considerable attention from academia and are adopted by various industrial domains, such as automotive, avionics, etc. As many of them are considered safety-critical, testing is indispensable to verify their reliability and safety. However, there is no common standard for testing autonomous systems efficiently and effectively. Thus new approaches for te

To meet future challenges from an older and physically less active population innovative solutions are needed. Modern Technology against Falls (MoTFall) aims to prevent falls, increase physical activity and improve self-rated health among older people by means of an information and communication technology based system. The project has developed technology-based solutions, focusing on person-centr

In this comment, we respond to the claim of (Bodin, Sustain Sci 16: 2151–2155, 2021) that sustainability science, as a research community, has begun to “lean to the left” in a problematic manner. On one hand, we remain unconvinced by the examples cited as indications for this tendency, and argue for caution in making such judgements. On the other hand, we hold that that there may be reasons for se

The association between having a sibling diagnosed with alcohol use disorder (AUD) and risk for suicide attempt may be attributable to shared genetic liability between AUD and suicidal behavior, effects of environmental exposure to a sibling’s AUD, or both. To distinguish between these alternatives, we conducted a series of Cox regression models using data derived from Swedish population-based reg

Genes encoding B lineage–restricted transcription factors are frequently mutated in B-lymphoid leukemias, suggesting a close link between normal and malignant B-cell development. One of these transcription factors is early B-cell factor 1 (EBF1), a protein of critical importance for lineage specification and survival of B-lymphoid progenitors. Here, we report that impaired EBF1 function in mouse B

In amyloid light chain (AL) amyloidosis, amyloid fibrils derived from immunoglobulin light chain are deposited in many organs, interfering with their function. The etiology of AL amyloidosis is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited by Mendelian randomization (MR) methodology to search for factors influencingALamyloidosi

Background: Despite increased interest in MSC-based cell therapies for the acute respiratory distress syndrome (ARDS), clinical investigations have not yet been successful and understanding of the potential in vivo mechanisms of MSC actions in ARDS remain limited. ARDS is driven by an acute severe innate immune dysregulation, often characterized by inflammation, coagulation, and cell injury. How t

Background: A distorted blood lipid profile is an important risk factor for ischemic heart disease (IHD) but the predictive ability of the different lipid measures has rarely been studied. Our aim was to examine and compare, in a large sample of women, the predictive ability of total cholesterol/HDL cholesterol ratio (TC/HDL-C) and non-HDL-C in relation to IHD, adjusted for age, exercise, smoking,

This article seeks to recover strands of liberalism in Cambodian politics from the period leading up to Independence onwards. It uses Bell’s (2014) summative conception of the liberal tradition, which understands liberalism contextually as a constructed and contested historical phenomenon. The starting point of the analysis is liberalism from the vantage point of the present: today’s half-hearted

Background: General practitioners (GPs) play a key role in managing the COVID-19 outbreak. However, they may encounter difficulties adapting their practices to the pandemic. We provide here an analysis of guidelines for the reorganisation of GP surgeries during the beginning of the pandemic from 15 countries. Methods: A network of GPs collaborated together in a three-step process: (i) identificati

Background: People with Parkinson’s disease are less physically active than controls. It is important to promote physical activity, which can be assessed using different methods. Subjective measures include physical activity questionnaires, which are easy and cheap to administer in clinical practice. Knowledge of the psychometric properties of physical activity questionnaires for people with Parki

Background: Suicide in old age is a significant contributor to mortality. However, the extent to which life weariness and suicidal thoughts impact on mortality in a long-term perspective is unknown. The aim of this study was to investigate the effect of life weariness and suicidal thoughts on long-term survival (16 years) in an older Swedish population, controlling for demographic and social netwo

The Great Green Wall Initiative (GGWI) is a pan-African program launched in 2007 to combat land degradation and bring about both ecological and socio-economic benefits in the Sahel. With projects in place on only one-fifth of the targeted land and uncertainty about the extent of positive impacts, there is a need for improved monitoring and evaluation of current projects to inform the design of fut

”Invasiva främmande arter” är ett uttryck som hörs allt oftare, såväl i medier som i diskussioner vid fikabordet. Vad är då en invasiv främmande art och varför väcker dessa arter så starka känslor? Varför är de ett problem? Hur blir man av med dem? Har de några positiva egenskaper? Det är några av de frågor vi tar upp i den här boken som är ett resultat av det tvärvetenskapliga forskningstemat ”Pe

Global climate change is projected to intensify soil drying-rewetting (DRW) events with extended drought, especially in arid and semiarid ecosystems. However, the extent to which the soil DRW with intensified drought can alter soil respiration (Rs) in forests is still under debate, and subsequent legacy effects on Rs are not well understood. Here, we conducted a 180-d soil incubation experiment to