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Aims/hypothesis: The study aimed to investigate the effects of HLA class I genes on susceptibility to type 1 diabetes with different onset ages, in addition to the well-established effects of HLA class II genes. Methods: A total of 361 patients with type 1 diabetes (192 patients with onset <18 years and 169 patients with onset ≥18 years) and 500 healthy control participants from China were enrolle

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This article explores why cultural branding – ideo-affective market communication addressing intense political tensions – paradoxically seems to lead to political inertia rather than political mobilization. I critically analyse advertising addressing political tensions related to race, ethnicity and immigration, but instead of only following the traced-out trajectory of postcolonial theory, I use

The use of 3D city models is changing from visualization to complex use cases where they act as 3D base maps. This requires links to registers and continuous updating of the city models. Still, most models never change or are recreated instead of updated. This study identifies obstacles to version management of 3D city models and proposes recommendations to overcome them, with a main focus on the

We conduct Metropolis Monte Carlo simulations on models of dilute colloidal dispersions, where the particles interact via isotropic potentials of mean force (PMFs) that display a long-ranged repulsion, combined with a short-ranged and narrow attraction. Such systems are known to form anisotropic clusters. There are two main conclusions from this work. First, we demonstrate that the width of the at

Per- and polyfluoroalkyl substances (PFAS) have been extensively used as surfactants because of their high stability and good water/oil-repellent properties. PFASs, especially perfluoroalkyl acids (PFAAs), have long biological half-lives, and exposure may cause adverse health effects in humans. We assessed temporal trends of concentrations of eight PFAAs in serum of Swedish adolescents (age 16–21

Objectives: The aim of this study was to determine risk factors for development of acute myeloid leukemia/myelodysplastic syndromes (AML/MDS) in patients with multiple myeloma (MM). Methods: We identified all patients diagnosed with MM in Sweden from January 1st, 1958 to December 31, 2011. A total of 26 627 patients were diagnosed with MM with during the study period. Of these, 124 patients (0.5%)

Penalty kicks in soccer provide a unique scenario in which to examine human choice behavior under competitive conditions. Here, we report two studies examining the tendency for soccer kickers to select the goal side with the largest area to the left or right of the goalkeeper’s veridical midline, when the goalkeeper stands marginally off-center. In Study I participants viewed realistic images of a

Early recognition and elimination of invading pathogens by the innate immune system, is one of the most efficient host defense mechanisms preventing the induction of systemic complications from infection. To this end the host can mobilize endogenous antimicrobials capable of killing the intruder by perforating the microbial cell wall. Here, we show that Streptococcus pyogenes can shield its outer

Recurrent circuitry components are distributed widely within the brain, including both excitatory and inhibitory synaptic connections. Recurrent neuronal networks have potential stability problems, perhaps a predisposition to epilepsy. More generally, instability risks making internal representations of information unreliable. To assess the inherent stability properties of such recurrent networks,

Measurement of two groups of autoantibodies, rheumatoid factor (RF) and anti-citrullinated protein/peptide antibodies (ACPA) have gained increasing significance in the diagnosis and classification of rheumatoid arthritis (RA) over the last 65 years. Despite this rising importance of autoimmune serology in RA, there is a palpable lack of harmonization between different commercial RF and ACPA tests.

Neural transplantation is a potential therapeutic method for Parkinson’s disease (PD). Fetal dopaminergic (DA) neurons have been important transplantation cell sources in the history of replacement therapy for PD. Several decades of preclinical animal experiments and clinical trials using fetal DA neuron transplantation in PD therapy have shown not only promising results but also problems. In orde

How and why did African households under colonial rule make the decision to educate their children or not, and how did this micro- level decision making affect the diffusion of education in colonial Ghana? This paper addresses these questions and shows that many households were reluctant to enrol their children in school because the costs of colonial education were prohibitive, and the benefits we

FLASH radiotherapy has emerged as a treatment technique with great potential to increase the differential effect between normal tissue toxicity and tumor response compared to conventional radiotherapy. To evaluate the feasibility of FLASH radiotherapy in a relevant clinical setting, we have commenced a feasibility and safety study of FLASH radiotherapy in canine cancer patients with spontaneous su

Aims: Alexithymia has been linked to cardiovascular disease. The aim was to explore whether the immuno-inflammatory variables galectin-3 binding protein (Gal3BP), soluble (s)CD163 and galectin-3 were independently associated with alexithymia, while controlling for known risk factors for cardiovascular disease, such as depression, anxiety, impaired glycemic control, obesity, smoking, and physical i

The fate of the Masurian Lutherans in eastern Poland is one of the tragedies of modern Europe. This chapter monitors the various, and often contradictory, attempts to transform a group that often escaped attempts at cultural and political classification. During the post-WWII era, various efforts to support this group were made by the part of European co-religionists. In this chapter is found a fir

Retrofitting historical buildings towards net zero energy building (NetZEB) in Northern countries is facing some issues confirmed in the literature review of this study. Following a holistic approach proposed by the authors, a 150-year old castle situated in Helsingborg, Sweden, was used to evaluate the potential of historical buildings in the Nordics to be turned into a NetZEB building. Following

Bees are typically diurnal but around 1% of described species have nocturnal activity. Nocturnal bees are still poorly studied due to bias towards studying diurnal insects. However, knowledge concerning their biology and role as crop pollinators has increased. We review the literature on nocturnal bees’ traits and their host plants, and assess the crop pollination effectiveness of this neglected g