Context and Objective: Intraportal islet transplantation can restore insulin production in type 1 diabetes patients, but its effect is subject to several interfering processes. To assess the influence of beta-cell loss before and during engraftment, we searched for a real-time marker of beta-cell destruction. Previous studies showed that 65-kDa isoform of glutamate decarboxylase (GAD65) is dischar

Background: Psychosocial stress has been identified as a risk factor in association with cardiovascular disease but less attention has been paid to heterogeneity in vulnerability to stress. The serial Color Word Test (CWT) measures adaptation to a stressful situation and it can be used to identify individuals that are vulnerable to stress. Prospective studies have shown that individuals with a mal

Desertification, climate variability and food security are closely linked through drought, land cover changes, and climate and biological feedbacks. In Ghana, only few studies have documented these linkages. To establish this link the study provides historical and predicted climatic changes for two drought sensitive agro-ecological zones in Ghana and further determines how these changes have influ

There is a growing need to understand how existing concepts and tools for sustainability relate to each other and to a robust, trans-disciplinary systems perspective for sustainability. As a response, a group of scientists, including some of the authors, have developed a framework based on backcasting from sustainability principles over the last 20 years the Framework for Strategic Sustainable Dev

The S 2p core level photoelectron spectra of Sulphurhexafluoride Clusters have been investigated together with heterogeneous Ar/SF6 clusters, created by doping Ar host clusters (with a mean size of 3600 atoms) with the molecule. Surface and bulk features are resolved both in the argon 2p and the sulphur 2p core level photoelectron spectra. For the latter level such features were only observed in t

One major challenge to the improvement of regional climate scenarios for the northern high latitudes is to understand land surface feedbacks associated with vegetation shifts and ecosystem biogeochemical cycling. We employed a customized, Arctic version of the individual-based dynamic vegetation model LPJ-GUESS to simulate the dynamics of upland and wetland ecosystems under a regional climate mode

Background: Genetic factors seem to be of greater importance in prostate cancer than in other forms of cancer. Studies have suggested familial concordance in survival, but the extent to which that is due to tumor characteristics is not known. Objective: We hypothesized that a brother of an index case with prostate cancer is at particularly increased risk of prostate cancer with the same tumor diff

There is a propensity in many languages for elements that represent backgrounded and/or given information to show up in the middle field, a tendency that I term SHIFT. In this paper I argue that Object Shift and the raising of certain adverbials to the middle field in Swedish is due to this general propensity. SHIFT applies across the board, but language-specific principles, such as Constituent Or

High transverse momentum jets produced in pp collisions at a centre of mass energy of 7 TeV are used to measure the transverse energy-energy correlation function and its associated azimuthal asymmetry. The data were recorded with the ATLAS detector at the LHC in the year 2011 and correspond to an integrated luminosity of 158 pb(-1). The selection criteria demand the average transverse momentum of

A central point of departure for this socio-legal study about online hate crimes concerns the significance of analysing and understanding social norms in relation to these crimes on the Internet. This is of importance not least when one approaches the issue of how law and the legal system may contribute towards positive developments in this field and prevent hate crimes. It is apparent that law an

The ground state properties of Mg-31 indicate a change of nuclear shape at N = 19 with a deformed J(pi) = 1/2(+) intruder state as a ground state, implying that Mg-31 is part of the "island of inversion". The collective properties of excited states were the subject of a Coulomb excitation experiment at REX-ISOLDE, CERN, employing a radioactive Mg-31 beam. De-excitation gamma-rays were detected by

The question of the concept of truth in the story of Pelagia,a hagiography about the repentent sinner Pelagia, and other hagiographical texts and in the New Testament is analyzed. It seems that the concept of truth is a rather simple one, and explicit assurances of truth is a sign of a not so trustworthy text.

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Inflammation i struphuvudet kan bero på annat än reflux Bakre laryngit är en form av kronisk inflammation som påverkar struphuvudets bakre del och ibland stämbanden samt ingången till matstrupen. Det kan ge upphov till symtom i form av hosta, heshet, ökad slembildning och klumpkänsla i halsen. Inflammationen kan orsakas av flera olika Posterior laryngitis (PL) is defined as an inflammation involving the posterior part of the glottal region in conjunction with symptoms. The cause is multifactorial. The aims of the work presented in this thesis were to examine symptoms, physical signs, different aetiologies and health-related quality of life (HRQOL) in patients with PL and/or oesophageal dysmotility. In paper I, a group of pati

Three large-scale Echovirus (E) epidemics (E4,E16,E30), each differently associated to the acute development of diabetes related autoantibodies, have been documented in Cuba. The prevalence of islet cell autoantibodies was moderate during the E4 epidemic but high in the E16 and E30 epidemic. The aim of this study was to evaluate the effect of epidemic strains of echovirus on beta-cell lysis, beta-